Bimosiamose, an inhaled small-molecule pan-selectin antagonist, attenuates late asthmatic reactions following allergen challenge in mild asthmatics: a randomized, double-blind, placebo-controlled clinical cross-over-trial.

[1]  S. Romano Selectin Antagonists , 2012, Treatments in respiratory medicine.

[2]  G. Wolff,et al.  Physiochemical properties, safety and pharmacokinetics of bimosiamose disodium after intravenous administration. , 2005, International journal of clinical pharmacology and therapeutics.

[3]  William N. Venables,et al.  An Introduction To R , 2004 .

[4]  E. Gelfand,et al.  Inhibition of early airway neutrophilia does not affect development of airway hyperresponsiveness. , 2004, American journal of respiratory cell and molecular biology.

[5]  B. Jensen,et al.  Pharmacoscintigraphic Comparison of HMR 1031, a VLA-4 Antagonist, in Healthy Volunteers Following Delivery Via a Nebulizer and a Dry Powder Inhaler , 2004, American journal of therapeutics.

[6]  H. Boushey,et al.  Effect of a single dose of the selectin inhibitor TBC1269 on early and late asthmatic responses , 2004, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

[7]  R. Dixon,et al.  Blockade of cell adhesion by a small molecule selectin antagonist attenuates myocardial ischemia/reperfusion injury. , 2003, European journal of pharmacology.

[8]  L. Boulet,et al.  The effects of an anti-CD11a mAb, efalizumab, on allergen-induced airway responses and airway inflammation in subjects with atopic asthma. , 2003, The Journal of allergy and clinical immunology.

[9]  G. Wolff,et al.  Development of Synthetic Pan-Selectin Antagonists: A New Treatment Strategy for Chronic Inflammation in Asthma , 2003, Pathobiology.

[10]  M. Sears Adverse effects of -agonists , 2002 .

[11]  R. Dixon,et al.  A Selectin Inhibitor Decreases Neutrophil Infiltration during Acute Mannheimia haemolytica Pneumonia , 2002, Veterinary pathology.

[12]  P. Barnes,et al.  The allergen challenge , 2002, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

[13]  R L Juliano,et al.  Signal transduction by cell adhesion receptors and the cytoskeleton: functions of integrins, cadherins, selectins, and immunoglobulin-superfamily members. , 2002, Annual review of pharmacology and toxicology.

[14]  P. O'Byrne,et al.  Dose-dependent effects of inhaled mometasone furoate on airway function and inflammation after allergen inhalation challenge. , 2001, American journal of respiratory and critical care medicine.

[15]  D. Bates,et al.  Mixed-Effects Models in S and S-PLUS , 2001 .

[16]  A. Coates,et al.  Nebulizer choice for inhaled colistin treatment in cystic fibrosis. , 2001, Chest.

[17]  K. Chung,et al.  Effects of an interleukin-5 blocking monoclonal antibody on eosinophils, airway hyper-responsìveness, and the late asthmatic response , 2000, The Lancet.

[18]  M. Gimbrone,et al.  E-Selectin-Dependent Signaling Via the Mitogen-Activated Protein Kinase Pathway in Vascular Endothelial Cells1 , 2000, The Journal of Immunology.

[19]  P. O'Byrne,et al.  Protective effects of fluticasone on allergen-induced airway responses and sputum inflammatory markers. , 2000, Canadian respiratory journal.

[20]  S. Newman Can lung deposition data act as a surrogate for the clinical response to inhaled asthma drugs? , 2000, British journal of clinical pharmacology.

[21]  R. Dixon,et al.  Inhibition of adhesion of human neutrophils and eosinophils to P-selectin by the sialyl Lewis antagonist TBC1269: preferential activity against neutrophil adhesion in vitro. , 2000, The Journal of allergy and clinical immunology.

[22]  B. O'connor,et al.  Comparison of incremental and bolus dose inhaled allergen challenge in asthmatic patients , 2000, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

[23]  J. Hankinson,et al.  Guidelines for methacholine and exercise challenge testing-1999. This official statement of the American Thoracic Society was adopted by the ATS Board of Directors, July 1999. , 2000, American journal of respiratory and critical care medicine.

[24]  P. Barry,et al.  An in vitro analysis of the output of budesonide from different nebulizers. , 1999, The Journal of allergy and clinical immunology.

[25]  L. Toledo-Pereyra,et al.  Upregulation of lung chemokines associated with hemorrhage is reversed with a small molecule multiple selectin inhibitor. , 1999, Journal of the American College of Surgeons.

[26]  J. Wildhaber,et al.  Inhalation therapy in asthma: nebulizer or pressurized metered-dose inhaler with holding chamber? In vivo comparison of lung deposition in children. , 1999, The Journal of pediatrics.

[27]  P. Barry,et al.  An in vitro analysis of the output of salbutamol from different nebulizers. , 1999, The European respiratory journal.

[28]  A. Zwinderman,et al.  The effect of montelukast (MK‐0476), a cysteinyl leukotriene receptor antagonist, on allergen‐induced airway responses and sputum cell counts in asthma , 1999, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

[29]  R. Dixon,et al.  Selectin blockade prevents antigen-induced late bronchial responses and airway hyperresponsiveness in allergic sheep. , 1999, American journal of respiratory and critical care medicine.

[30]  Francesco Saverio Tedesco,et al.  Endothelial Cell E- and P-Selectin and Vascular Cell Adhesion Molecule-1 Function as Signaling Receptors , 1998, The Journal of cell biology.

[31]  P. Barnes,et al.  Allergen-induced early and late asthmatic responses are not affected by inhibition of endogenous nitric oxide. , 1998, American journal of respiratory and critical care medicine.

[32]  R. Dixon,et al.  Novel synthetic inhibitors of selectin-mediated cell adhesion: synthesis of 1,6-bis[3-(3-carboxymethylphenyl)-4-(2-alpha-D- mannopyranosyloxy)phenyl]hexane (TBC1269). , 1998, Journal of medicinal chemistry.

[33]  L. Toledo-Pereyra,et al.  Small-molecule selectin inhibitor protects against liver inflammatory response after ischemia and reperfusion. , 1997, Journal of the American College of Surgeons.

[34]  N. Choudry,et al.  Evaluation of single-dose inhaled corticosteroid activity with an allergen challenge model. , 1997, The Journal of allergy and clinical immunology.

[35]  G S Kansas,et al.  Selectins and their ligands: current concepts and controversies. , 1996, Blood.

[36]  R. Pauwels,et al.  GLOBAL STRATEGY FOR ASTHMA MANAGEMENT AND PREVENTION , 1996 .

[37]  H. Magnussen,et al.  The effect of ozone exposure on allergen responsiveness in subjects with asthma or rhinitis. , 1996, American journal of respiratory and critical care medicine.

[38]  John L. Hankinson,et al.  Standardization of Spirometry, 1994 Update. American Thoracic Society. , 1995, American journal of respiratory and critical care medicine.

[39]  P. O'Byrne,et al.  Reproducibility of allergen-induced early and late asthmatic responses. , 1995, The Journal of allergy and clinical immunology.

[40]  C. Bertozzi,et al.  The selectins and their ligands. , 1994, Current opinion in cell biology.

[41]  E. Scarpini,et al.  Sulfatides trigger increase of cytosolic free calcium and enhanced expression of tumor necrosis factor-alpha and interleukin-8 mRNA in human neutrophils. Evidence for a role of L-selectin as a signaling molecule. , 1994, The Journal of biological chemistry.

[42]  Stephen Senn,et al.  Cross-over trials in clinical research , 1993 .

[43]  Buist As Standardization of spirometry. , 1987 .