A Concise Summary of Coagulation in Liver

The cell-based model of coagulation depicts the complex interactions of pro and anticoagulant factors, fibrinolytic proteins, platelets and vascular endothelial components that are required for balanced haemostasis to take place. The liver plays a key role in haemostasis as hepatic parenchymal cells synthesise the majority of coagulation factors, anticoagulant proteins and constituents of the fibrinolytic system. Liver disease can consequently have a profound impact on the interplay of these components and impair haemostatic competence [1].

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