Antiretroviral agent (R)-9-(2-phosphonomethoxypropyl)adenine stimulates cytokine and nitric oxide production.

[1]  E. Vizi,et al.  Adenosine receptor agonists differentially regulate IL-10, TNF-alpha, and nitric oxide production in RAW 264.7 macrophages and in endotoxemic mice. , 1996, Journal of immunology.

[2]  D. Torre,et al.  Immunological aspects of nitric oxide in HIV-1 infection. , 1996, Medical hypotheses.

[3]  C. Perno,et al.  Potent inhibition of human immunodeficiency virus and herpes simplex virus type 1 by 9-(2-phosphonylmethoxyethyl)adenine in primary macrophages is determined by drug metabolism, nucleotide pools, and cytokines. , 1996, Molecular pharmacology.

[4]  I. Votruba,et al.  Different inhibitory potencies of acyclic phosphonomethoxyalkyl nucleotide analogs toward DNA polymerases alpha, delta and epsilon. , 1996, Molecular pharmacology.

[5]  O. Moine,et al.  Adenosine enhances IL-10 secretion by human monocytes. , 1996, Journal of immunology.

[6]  G. Firestein,et al.  Inhibition of TNF-alpha expression by adenosine: role of A3 adenosine receptors. , 1996, Journal of immunology.

[7]  R. Grant,et al.  Antiviral efficacy of PMPA in macaques chronically infected with SIV , 1996 .

[8]  E. De Clercq,et al.  Activity of the (R)-enantiomers of 9-(2-phosphonylmethoxypropyl)-adenine and 9-(2-phosphonylmethoxypropyl)-2,6-diaminopurine against human immunodeficiency virus in different human cell systems. , 1996, Biochemical and biophysical research communications.

[9]  E. De Clercq,et al.  Antiretroviral activity and pharmacokinetics in mice of oral bis(pivaloyloxymethyl)-9-(2-phosphonylmethoxyethyl)adenine, the bis(pivaloyloxymethyl) ester prodrug of 9-(2-phosphonylmethoxyethyl)adenine , 1996, Antimicrobial agents and chemotherapy.

[10]  A. Fauci An elusive soluble suppressor , 1995, Nature.

[11]  R. Grant,et al.  Prevention of SIV Infection in Macaques by (R)-9-(2-Phosphonylmethoxypropyl)adenine , 1995, Science.

[12]  G. Strassmann,et al.  Cyclic nucleotide phosphodiesterase type IV participates in the regulation of IL-10 and in the subsequent inhibition of TNF-alpha and IL-6 release by endotoxin-stimulated macrophages. , 1995, Journal of immunology.

[13]  M. Sinet,et al.  Inhibitory effect of nitric oxide on the replication of a murine retrovirus in vitro and in vivo , 1995, Journal of virology.

[14]  A. Collier,et al.  Clinical pharmacokinetics of adefovir in human immunodeficiency virus type 1-infected patients , 1995, Antimicrobial agents and chemotherapy.

[15]  U. Förstermann,et al.  Isoforms of nitric oxide synthase. Properties, cellular distribution and expressional control. , 1995, Biochemical pharmacology.

[16]  J. Cherrington,et al.  Kinetic Interaction of the Diphosphates of 9-(2-phosphonylmethoxyethyl)adenine and Other anti-HIV Active Purine Congeners with HIV Reverse Transcriptase and Human DNA Polymerases α, β and γ , 1995 .

[17]  S. Corradin,et al.  Effect of PGE2 and of agents that raise cAMP levels on macrophage activation induced by IFN‐γ and TNF‐α , 1995, Journal of leukocyte biology.

[18]  S. Reed,et al.  IL-10 is induced during HIV-1 infection and is capable of decreasing viral replication in human macrophages. , 1994, Journal of immunology.

[19]  H. Schuitemaker,et al.  Interference of interleukin-10 with human immunodeficiency virus type 1 replication in primary monocyte-derived macrophages , 1994, Journal of virology.

[20]  M. Feldmann,et al.  Two inhibitors of pro‐inflammatory cytokine release, interleukin‐10 and interleukin‐4, have contrasting effects on release of soluble p75 tumor necrosis factor receptor by cultured monocytes , 1994, European journal of immunology.

[21]  R. Kornbluth,et al.  Overview of HIV interactions with macrophages and dendritic cells: the other infection in AIDS , 1994, Journal of leukocyte biology.

[22]  A. Foli,et al.  Interleukin-10 suppresses human immunodeficiency virus-1 replication in vitro in cells of the monocyte/macrophage lineage , 1994 .

[23]  R. Grant,et al.  Preexposure prophylaxis with 9-(2-phosphonylmethoxyethyl)adenine against simian immunodeficiency virus infection in macaques. , 1994, The Journal of infectious diseases.

[24]  G. Constantin,et al.  Interleukin 10 (IL-10) inhibits the release of proinflammatory cytokines from human polymorphonuclear leukocytes. Evidence for an autocrine role of tumor necrosis factor and IL-1 beta in mediating the production of IL-8 triggered by lipopolysaccharide , 1993, The Journal of experimental medicine.

[25]  G. Karupiah,et al.  Inhibition of viral replication by interferon-gamma-induced nitric oxide synthase. , 1993, Science.

[26]  L. Montaner,et al.  Interleukin 13 inhibits human immunodeficiency virus type 1 production in primary blood-derived human macrophages in vitro , 1993, The Journal of experimental medicine.

[27]  N. Fasel,et al.  Induction of macrophage nitric oxide production by interferon‐γ and tumor necrosis factor‐α is enhanced by interleukin‐10 , 1993 .

[28]  Marian C. Horzinek,et al.  Use of two virustatica (AZT, PMEA) in the treatment of FIV and of FeLV seropositive cats with clinical symptoms. , 1992, Veterinary immunology and immunopathology.

[29]  Y. Vodovotz,et al.  Macrophage deactivation by interleukin 10 , 1991, The Journal of experimental medicine.

[30]  T. Mosmann,et al.  IL-10 inhibits cytokine production by activated macrophages. , 1991, Journal of immunology.

[31]  E. De Clercq,et al.  Activity of acyclic nucleoside phosphonate analogues against human immunodeficiency virus in monocyte/macrophages and peripheral blood lymphocytes. , 1991, Biochemical and biophysical research communications.

[32]  J. Justement,et al.  Transforming growth factor beta suppresses human immunodeficiency virus expression and replication in infected cells of the monocyte/macrophage lineage , 1991, The Journal of experimental medicine.

[33]  H. Gendelman,et al.  Regulation of HIV replication in infected monocytes by IFN-alpha. Mechanisms for viral restriction. , 1990, Journal of immunology.

[34]  I. Votruba,et al.  Inhibition of avian myeloblastosis virus reverse transcriptase by diphosphates of acyclic phosphonylmethyl nucleotide analogues. , 1990, Antiviral research.

[35]  G. Beall,et al.  Infection with HIV is associated with elevated IL-6 levels and production. , 1990, Journal of immunology.

[36]  M. Marletta,et al.  Macrophage oxidation of L-arginine to nitrite and nitrate: nitric oxide is an intermediate. , 1988, Biochemistry.

[37]  E. Hersh,et al.  Idiopathic production of interleukin-1 in acquired immune deficiency syndrome , 1987, Journal of clinical microbiology.

[38]  A. Holý,et al.  Synthesis of Enantiomeric N -(2-Phosphonomethoxypropyl) Derivatives of Purine and Pyrimidine Bases. II. The Synthon Approach , 1995 .

[39]  A. Heredia,et al.  Interferon-gamma-induced downregulation of CD4 inhibits the entry of human immunodeficiency virus type-1 in primary monocytes. , 1995, Pathobiology : journal of immunopathology, molecular and cellular biology.

[40]  E. De Clercq,et al.  Enhancement of natural killer activity and interferon induction by different acyclic nucleoside phosphonates. , 1994, Antiviral research.

[41]  J. Justement,et al.  Tumor necrosis factor alpha functions in an autocrine manner in the induction of human immunodeficiency virus expression. , 1990, Proceedings of the National Academy of Sciences of the United States of America.