Characterization of [123I]FP‐CIT binding to the dopamine transporter in the striatum of tree shrews by quantitative in vitro autoradiography

Aim of this study was to quantify the binding of [123I]FP‐CIT in striatum of healthy tree shrews. [123I]FP‐CIT is widely used in clinical SPECT imaging to reveal nigrostriatal degeneration in aid of the diagnosis of clinically uncertain parkinsonian syndromes. Despite its wide clinical use, the saturation binding parameters of [123I]FP‐CIT for the dopamine transporter (DAT) have not yet been determined in any mammalian brain. Tree shrews are genetically and neuroanatomically more similar to humans than are rodents and might therefore be a valuable animal model for research of neurological disorders involving brain dopamine.

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