Synergistic interaction of miconazole and fluconazole at sub‐MIC level on Candida albicans

Zusammenfassung. Es wurde die kombinierte Wirkung zweier Azole, Miconazol und Fluconazol, auf Candida albicans untersucht. Über die Bestimmung der minimalen Hemmkonzentrationen (MHK), der subinhibitorischen Konzentrationen und der fraktionierten Hemmkonzentrationen konnte eine synergistische Wirkung beider Antimyzetika unterhalb der jeweils individuellen minimalen Hemmkonzentration aufgezeigt werden. Der fraktionierte Hemmkonzentrations‐Index lag im Bereich von 0.3 bis 1.0, und der Synergismus war charakterisiert durch die Potenzierung der Fluconazol‐Wirkung durch Miconazol. Die synergistische Wirkung konnte auch mit der turbidimetrischen Methode belegt werden. Andererseits wurde bei C. krusei kein synergistischer Effekt gefunden.

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