论文信息 - Discrete sequential boundaries for clinical trials

Discrete sequential boundaries for clinical trials

SUMMARY Pocock (1977), O'Brien & Fleming (1979) and Slud & Wei (1982) have proposed different methods to construct discrete sequential boundaries for clinical trials. These methods require that the total number of decision times be specified in advance. In the present paper, we propose a more flexible way to construct discrete sequential boundaries. The method is based on the choice of a function, a*(t), which characterizes the rate at which the error level ac is spent. The boundary at a decision time is determined by a*(t), and by past and current decision times, but does not depend on the future decision times or the total number of decision times.

K. K. Lan | D. DeMets

[1] P. Armitage,et al. Repeated Significance Tests on Accumulating Data , 1969 .

[2] P. Sen,et al. Rank order tests for grouped data under progressive censoring , 1977 .

[3] S. Pocock. Group sequential methods in the design and analysis of clinical trials , 1977 .

[4] C. E. Davis,et al. A two sample wilcoxon test for progressively censored data , 1978 .

[5] A. Petkau,et al. Sequential testing of the equality of two survival distributions using the modified Savage statistic , 1978 .

[6] P. O'Brien,et al. A multiple testing procedure for clinical trials. , 1979, Biometrics.

[7] David M. De Long. Crossing probabilities for a square root boundary by a bessel process , 1981 .

[8] K. K. Lan,et al. Stochastically curtailed tests in long–term clinical trials , 1982 .

[9] Eric V. Slud,et al. Two-Sample Repeated Significance Tests Based on the Modified Wilcoxon Statistic , 1982 .

[10] S J Pocock,et al. Interim analyses for randomized clinical trials: the group sequential approach. , 1982, Biometrics.