Changes in the Hemostatic Mechanism After Myocardial Infarction

Plasma coagulation factors, adenosine diphosphate-induced platelet aggregation, and fibrinolytic activity were studied in male survivors of myocardial infarction and in healthy normal men. Infarction survivors had significant elevations of factors VIII and X and of adenosine diphosphate-induced platelet aggregation. The fibrinolytic system was altered toward reduced plasminogen activation, increased antiurokinase activity, and elevated antiplasmin activity. These findings suggest that some men with prior myocardial infarction have a heightened tendency to thrombogenesis. This tendency may represent a response to previous cardiac insult or may contribute to its pathogenesis.

[1]  G. Cooper,et al.  The determination of ADP-induced platelet aggregation in normal men. , 1970, Atherosclerosis.

[2]  R. Chakrabarti,et al.  Reaction pattern to three stresses—electroplexy, surgery, and myocardial infarction—of fibrinolysis and plasma fibrinogen , 1969, Journal of clinical pathology.

[3]  J. Zahavi,et al.  An Abnormal Pattern of Adenosine Diphosphate-Induced Platelet Aggregation in Acute Myocardial Infarction , 1969, Thrombosis and Haemostasis.

[4]  L. Gaston,et al.  Preparation of canine factor VII deficient substrate plasma. , 1968, The Journal of laboratory and clinical medicine.

[5]  J. O'brien,et al.  Effects of salicylates on human platelets. , 1968, Lancet.

[6]  G. Izak,et al.  Studies on Hypercoagulable State , 1967, Thrombosis and Haemostasis.

[7]  R. Stathopoulou,et al.  Serum inhibition of plasmin and of plasminogen activation in thrombotic diseases. , 1967, Journal of atherosclerosis research.

[8]  A. J. Honour,et al.  Platelet behaviour and drugs used in cardiovascular disease. , 1967, Cardiovascular research.

[9]  E. Brandt,et al.  Plasma Fibrinogen Patterns in Patients with Coronary Atherosclerosis , 1966, Circulation.

[10]  C. J. Schwartz,et al.  In Vitro Thrombosis and Platelet Aggregation in Myocardial Infarction , 1966, British medical journal.

[11]  R. Chakrabarti,et al.  Fibrinolytic activity related to age in survivors of myocardial infarction. , 1966, Lancet.

[12]  Norman-Williams Cm.  MANAGEMENT OF POLYCYTHAEMIA VERA. , 1965 .

[13]  S. Naimi,et al.  Studies of Coagulation and Fibrinolysis of the Arterial and Venous Blood in Normal Subjects and Patients with Atherosclerosis , 1963, Circulation.

[14]  J. R. O'brien.  Platelet aggregation , 1962, Journal of clinical pathology.

[15]  J. Mustard,et al.  Coagulation Tests and Platelet Economy in Atherosclerotic and Control Subjects , 1962, Circulation.

[16]  R. R. Proctor,et al.  The partial thromboplastin time with kaolin. A simple screening test for first stage plasma clotting factor deficiencies. , 1961, American journal of clinical pathology.

[17]  S. Rapaport,et al.  A simple, specific one-stage assay for plasma thromboplastin antecedent activity. , 1961, The Journal of laboratory and clinical medicine.

[18]  A. Cooperberg,et al.  The concentration of antihemophilic globulin (AHG) in patients with coronary artery disease. , 1961, Annals of internal medicine.

[19]  K. Denson.  The specific assay of Prower-Stuart factor and factor VII. , 1961, Acta haematologica.

[20]  L. Mcdonald,et al.  Changes in coagulability of the blood during various phases of ischaemic heart-disease. , 1959, Lancet.

[21]  J. Mustard.  Blood coagulation in subjects with and without clinical evidence of atherosclerotic vessel disease. , 1958, Canadian Medical Association journal.

[22]  T. Astrup,et al.  The biological significance of fibrinolysis. , 1956, Lancet.

[23]  T. Astrup,et al.  The fibrin plate method for estimating fibrinolytic activity. , 1952, Archives of biochemistry and biophysics.

[24]  E. Cronkite,et al.  Morphology and enumeration of human blood platelets. , 1950, Journal of applied physiology.

[25]  P. Cohen,et al.  Partial purification and properties of a proteolytic enzyme of human serum. , 1949, The Journal of biological chemistry.

[26]  J. B. Duguid.  Thrombosis as a factor in the pathogenesis of coronary atherosclerosis. , 1946, The Journal of pathology and bacteriology.

[27]  G. Busk,et al.  A Manual of Pathological Anatomy , 1856, The British and foreign medico-chirurgical review.

[28]  S. Siegel,et al.  Nonparametric Statistics for the Behavioral Sciences , 2022, The SAGE Encyclopedia of Research Design.

[29]  R. Macfarlane.  The hemostatic mechanism and its defects. , 1968, International review of experimental pathology.

[30]  P. Wolf.  Fibrinolytic activity and coronary-artery disease. , 1968, Lancet.

[31]  T. Astrup,et al.  THE ESTIMATION OF FIBRINOGEN. A REVISION. , 1965, Scandinavian journal of clinical and laboratory investigation.