Dissociable Effects of a Single Dose of Ecstasy (MDMA) on Psychomotor Skills and Attentional Performance

Ecstasy (3,4-methylenedioxymethamphetamine, MDMA) is a psychoactive recreational drug widely used by young people visiting dance parties, and has been associated with poor cognitive function. The current study assessed the influence of a single dose of MDMA 75 mg and alcohol 0.5 g/kg on cognition, psychomotor performance and driving-related task performance. Twelve healthy recreational ecstasy users participated in an experimental study conducted according to a double-blind, double-dummy, placebo-controlled three-way cross-over design. MDMA improved psychomotor performance, such as movement speed and tracking performance in a single task, as well as in a divided attention task. MDMA impaired the ability to predict object movement under divided attention. However, the inability to accurately predict object movement after MDMA may indicate impairment of particular performance skills relevant to driving. There was no effect of MDMA on visual search, planning or retrieval from semantic memory.

[1]  H. R. Jex,et al.  A ``Critical'' Tracking Task for Manual Control Research , 1966 .

[2]  J. Downing.  The psychological and physiological effects of MDMA on normal volunteers. , 1986, Journal of psychoactive drugs.

[3]  P. Kelly.  Impaired cognitive performance in drug free users of recreational ecstasy (MDMA) , 2000, Journal of neurology, neurosurgery, and psychiatry.

[4]  Herbert Moskowitz,et al.  Laboratory studies of the effects of alcohol on some variables related to driving. , 1973 .

[5]  De Man Ra.  Morbidity and mortality caused by use of ecstasy , 1994 .

[6]  J. O'hanlon,et al.  A study of the pharmacodynamic interaction between befloxatone and ethanol on performance and mood in healthy volunteers , 1996, Journal of psychopharmacology.

[7]  M. Morgan,et al.  Ecstasy (MDMA): a review of its possible persistent psychological effects , 2000, Psychopharmacology.

[8]  U. McCann,et al.  Cognitive performance in (±) 3,4-methylenedioxymethamphetamine (MDMA, “ecstasy”) users: a controlled study , 1999, Psychopharmacology.

[9]  B. Logan,et al.  Methamphetamine and driving impairment. , 1996, Journal of forensic sciences.

[10]  S. Dawling,et al.  Toxicity and deaths from 3,4-methylenedioxymethamphetamine ("ecstasy") , 1992, The Lancet.

[11]  M. Morgan.  Memory deficits associated with recreational use of “ecstasy” (MDMA) , 1999, Psychopharmacology.

[12]  Adrian M. Owen,et al.  Dopamine-Dependent Frontostriatal Planning Deficits in Early Parkinson's Disease , 1995 .

[13]  H. Praag,et al.  Caffeine attenuates scopolamine-induced memory impairment in humans , 2005, Psychopharmacology.

[14]  A. Parrott,et al.  Ecstasy (MDMA) effects upon mood and cognition: before, during and after a Saturday night dance , 1998, Psychopharmacology.

[15]  J. Krystal,et al.  Chronic 3,4-methylenedioxymethamphetamine (MDMA) use: effects on mood and neuropsychological function? , 1992, The American journal of drug and alcohol abuse.

[16]  G. Mannaerts,et al.  Morbiditeit en sterfte als gevolg van ecstacygebruik , 1994 .

[17]  G A Starmer,et al.  The relationship between alcohol dosage and performance decrement in humans. , 1976, Journal of studies on alcohol.

[18]  T. Shallice.  Specific impairments of planning. , 1982, Philosophical transactions of the Royal Society of London. Series B, Biological sciences.

[19]  J. Henry.  Ecstasy and the dance of death. , 1992, BMJ.

[20]  F. Vollenweider,et al.  Psychological and Cardiovascular Effects and Short-Term Sequelae of MDMA (“Ecstasy”) in MDMA-Naïve Healthy Volunteers , 1998, Neuropsychopharmacology.

[21]  R. de la Torre,et al.  Cardiovascular and neuroendocrine effects and pharmacokinetics of 3, 4-methylenedioxymethamphetamine in humans. , 1999, The Journal of pharmacology and experimental therapeutics.

[22]  Michael F. Green,et al.  Training and quality assurance with the structured clinical interview for DSM-IV (SCID-I/P) , 1998, Psychiatry Research.

[23]  Donald A. Norman,et al.  A non-parametric analysis of recognition experiments , 1964 .

[24]  M. Farré,et al.  Fatal MDMA intoxication , 1999, The Lancet.

[25]  F. Couper,et al.  3,4-Methylenedioxymethamphetamine (MDMA, ecstasy) and driving impairment. , 2001, Journal of forensic sciences.

[26]  J. Jolles,et al.  Age-Related Decline of Psychomotor Speed: Effects of Age, Brain Health, Sex, and Education , 1993, Perceptual and motor skills.

[27]  J. Ramaekers,et al.  Effects of moclobemide and mianserin on highway driving, psychometric performance and subjective parameters, relative to placebo , 2005, Psychopharmacology.

[28]  J. Mørland,et al.  Toxicity of drug abuse--amphetamine designer drugs (ecstasy): mental effects and consequences of single dose use. , 2000, Toxicology letters.

[29]  A. Lees,et al.  Cognitive performance in recreational users of MDMA or 'ecstasy': evidence for memory deficits , 1998, Journal of psychopharmacology.

[30]  Adrian M. Owen,et al.  Dopamine-Dependent Frontostriatal Planning Deficits in Early Parkinson ' s Disease , 2004 .

[31]  J. O'hanlon,et al.  Effects of nocturnal doses of mirtazapine and mianserin on sleep and on daytime psychomotor and driving performance in young, healthy volunteers , 1998 .

[32]  R. de la Torre,et al.  Human pharmacology of 3,4-methylenedioxymethamphetamine ("ecstasy"): psychomotor performance and subjective effects. , 2000, Journal of clinical psychopharmacology.

[33]  J. Ramaekers,et al.  Visual search and urban driving under the influence of marijuana and alcohol , 2001, Human psychopharmacology.

[34]  J. O'hanlon,et al.  Fexofenadine's effects, alone and with alcohol, on actual driving and psychomotor performance. , 1998, The Journal of allergy and clinical immunology.

[35]  S. Heishman,et al.  Comparative Effects of Alcohol and Marijuana on Mood, Memory, and Performance , 1997, Pharmacology Biochemistry and Behavior.

[36]  J. V. van Gerven,et al.  Cognitive performance and serotonergic function in users of ecstasy , 2000, Psychopharmacology.