Screening and Biosensor-Based Approaches for Lung Cancer Detection

Early diagnosis of lung cancer helps to reduce the cancer death rate significantly. Over the years, investigators worldwide have extensively investigated many screening modalities for lung cancer detection, including computerized tomography, chest X-ray, positron emission tomography, sputum cytology, magnetic resonance imaging and biopsy. However, these techniques are not suitable for patients with other pathologies. Developing a rapid and sensitive technique for early diagnosis of lung cancer is urgently needed. Biosensor-based techniques have been recently recommended as a rapid and cost-effective tool for early diagnosis of lung tumor markers. This paper reviews the recent development in screening and biosensor-based techniques for early lung cancer detection.

[1]  Khairul Hamimah Abas,et al.  Magnetic induction tomography: A brief review , 2015 .

[2]  Jim M. Wild,et al.  Lung imaging in cystic fibrosis , 2009 .

[3]  Wang Bi A three-channel high-precision optical detecting system for lung cancer marker CYFRA21-1 , 2013 .

[4]  Feng Liu,et al.  Expression and clinicopathological significance of S100 calcium binding protein A2 in lung cancer patients of Chinese Han ethnicity. , 2017, Clinica chimica acta; international journal of clinical chemistry.

[5]  Shaoyi Jiang,et al.  irect detection of carcinoembryonic antigen autoantibodies in clinical human erum samples using a surface plasmon resonance sensor on Ladda , 2009 .

[6]  Marek Piliarik,et al.  Label-free detection of cancer biomarker candidates using surface plasmon resonance imaging , 2009, Analytical and bioanalytical chemistry.

[7]  Farrokh Karimi,et al.  Graphene oxide based nano-biosensor for the detection of deletion mutation in exon 19 of EGFR gene, leading to lung cancer , 2016 .

[8]  Yildiz Uludag,et al.  Cancer biomarker detection in serum samples using surface plasmon resonance and quartz crystal microbalance sensors with nanoparticle signal amplification. , 2012, Analytical chemistry.

[9]  Shusheng Zhang,et al.  Ultrasensitive Detection of DNA and Ramos Cell Using In Situ Selective Crystallization Based Quartz Crystal Microbalance. , 2017, Analytical chemistry.

[10]  Frank D Gilliland,et al.  Plutonium targets the p16 gene for inactivation by promoter hypermethylation in human lung adenocarcinoma. , 2004, Carcinogenesis.

[11]  Young Min Han,et al.  Comparison of Survival Rate in Primary Non-Small-Cell Lung Cancer Among Elderly Patients Treated With Radiofrequency Ablation, Surgery, or Chemotherapy , 2012, CardioVascular and Interventional Radiology.

[12]  E Chyczewska,et al.  K-ras codon 12 mutations may be detected in serum of patients suffering from adeno- and large cell lung carcinoma. A preliminary report. , 2001, Folia histochemica et cytobiologica.

[13]  Anthony J. Peyton,et al.  Performance of a FPGA-based Direct Digitising Signal Measurement module for MIT , 2010 .

[14]  G Parraga,et al.  TH-CD-202-09: Free-Breathing Proton MRI Functional Lung Avoidance Maps to Guide Radiation Therapy. , 2016, Medical physics.

[15]  A. N. Matlachov,et al.  Thin-Film Planar Gradiometer with Long Baseline , 2006 .

[16]  O. Dössel,et al.  Planar system for magnetic induction conductivity measurement using a sensor matrix. , 2004, Physiological measurement.

[17]  Yasar Gurbuz,et al.  Surface plasmon resonance based immunosensor for the detection of the cancer biomarker carcinoembryonic antigen. , 2011, Talanta.

[18]  W. Szeszkowski,et al.  Characterization of focal liver lesions using quantitative techniques: comparison of apparent diffusion coefficient values and T2 relaxation times , 2012, European Radiology.

[19]  Luca Marmugi,et al.  Optical Magnetic Induction Tomography of the Heart , 2016, Scientific Reports.

[20]  Lulu Wang,et al.  Imaging of Lung Structure Using Holographic Electromagnetic Induction , 2017, IEEE Access.

[21]  Zeynep Altintas,et al.  Biomarkers and biosensors for the early diagnosis of lung cancer , 2013 .

[22]  J. Austin,et al.  Detection of lung cancer using weighted digital analysis of breath biomarkers. , 2008, Clinica chimica acta; international journal of clinical chemistry.

[23]  Paul V Carlile Lung cancer screening: where have we been? Where are we going? , 2015, The Journal of the Oklahoma State Medical Association.

[24]  Min Han,et al.  Comparison with reconstruction algorithms in magnetic induction tomography , 2016, Physiological measurement.

[25]  G. Cooper,et al.  Cellular transforming genes. , 1982, Science.

[26]  P. Di Barba,et al.  Optimization of the MIT Field Exciter by a Multiobjective Design , 2009, IEEE Transactions on Magnetics.

[27]  Hui Li,et al.  CD59 is overexpressed in human lung cancer and regulates apoptosis of human lung cancer cells. , 2013, International journal of oncology.

[28]  R. Miceli,et al.  Tumour markers CEA, NSE, SCC, TPA and CYFRA 21.1 in resectable non-small cell lung cancer. , 1999, Anticancer research.

[29]  Masahiro Endo,et al.  Prognostic impact of serum CYFRA 21–1 in patients with advanced lung adenocarcinoma: a retrospective study , 2013, BMC Cancer.

[30]  Yang Zhao,et al.  Association between MicroRNA Polymorphisms, Expressions, Lung Cancer Development and Prognosis , 2009 .

[31]  Min Han,et al.  Magnetic Induction Tomography , 2015 .

[32]  Toshio Itoh,et al.  Development of an Exhaled Breath Monitoring System with Semiconductive Gas Sensors, a Gas Condenser Unit, and Gas Chromatograph Columns , 2016, Sensors.

[33]  Naveed Hasan,et al.  Lung Cancer Screening Beyond Low-Dose Computed Tomography: The Role of Novel Biomarkers , 2014, Lung.

[34]  Kathleen Brown,et al.  Lung cancer screening with CT. , 2008, Clinics in chest medicine.

[35]  R L Wahl,et al.  Metastases from non-small cell lung cancer: mediastinal staging in the 1990s--meta-analytic comparison of PET and CT. , 1999, Radiology.

[36]  J. Austin,et al.  Prediction of lung cancer using volatile biomarkers in breath. , 2007, Cancer biomarkers : section A of Disease markers.

[37]  S. Nicolaou,et al.  Traumatic pneumothorax detection with thoracic US: correlation with chest radiography and CT--initial experience. , 2002, Radiology.

[38]  Waseem Asghar,et al.  Electrical detection of cancer biomarker using aptamers with nanogap break-junctions , 2012, Nanotechnology.

[39]  C. Pöttgen,et al.  Surgery after multimodality treatment for non-small-cell lung cancer. , 2004, Lung cancer.

[40]  I. Behrmann,et al.  MiRNA-29: a microRNA family with tumor-suppressing and immune-modulating properties. , 2013, Current molecular medicine.

[41]  E. Martinelli,et al.  Lung cancer identification by the analysis of breath by means of an array of non-selective gas sensors. , 2003, Biosensors & bioelectronics.

[42]  Tetsuya Osaka,et al.  Label-free detection of tumor markers using field effect transistor (FET)-based biosensors for lung cancer diagnosis , 2015 .

[43]  Ning Xia,et al.  Simultaneous and label-free determination of wild-type and mutant p53 at a single surface plasmon resonance chip preimmobilized with consensus DNA and monoclonal antibody. , 2009, Analytical chemistry.

[44]  Yoon Hwan Chang,et al.  Comparison of the serum fibrin-fibrinogen degradation products with cytokeratin 19 fragment as biomarkers in patients with lung cancer. , 2014, Biomedical reports.

[45]  Bjørn Winther,et al.  Determination of the small cell lung cancer associated biomarker pro-gastrin-releasing peptide (ProGRP) using LC-MS. , 2007, Journal of separation science.

[46]  Anthony J. Peyton,et al.  Imaging molten steel flow profiles , 2001 .

[47]  K. Lewis,et al.  A review of novel biological tools used in screening for the early detection of lung cancer , 2009, Postgraduate Medical Journal.

[48]  H Scharfetter,et al.  Hardware for quasi-single-shot multifrequency magnetic induction tomography (MIT): the Graz Mk2 system. , 2008, Physiological measurement.

[49]  J. Howington,et al.  Survival after resection for lung cancer is the outcome that matters. , 2004, American journal of surgery.

[50]  M. Baiget,et al.  KRAS genetic variant as a prognostic factor for recurrence in resectable non-small cell lung cancer , 2017, Clinical and Translational Oncology.

[51]  Wei Chen,et al.  Detection EGFR exon 19 status of lung cancer patients by DNA electrochemical biosensor. , 2016, Biosensors & bioelectronics.

[52]  N. H. Saunders,et al.  A feasibility study of in vivo electromagnetic imaging. , 1993, Physics in medicine and biology.

[53]  J. Pyun,et al.  Additive assay of cancer marker CA 19-9 by SPR biosensor , 2006 .

[54]  Ulrike Tisch,et al.  Classification of lung cancer histology by gold nanoparticle sensors. , 2012, Nanomedicine : nanotechnology, biology, and medicine.

[55]  A. Weber,et al.  Performance of biomarkers SMRP, CA125, and CYFRA 21-1 as potential tumor markers for malignant mesothelioma and lung cancer in a cohort of workers formerly exposed to asbestos , 2011, Archives of Toxicology.

[56]  L M Lechuga,et al.  Label-free detection of DNA mutations by SPR: application to the early detection of inherited breast cancer , 2009, Analytical and bioanalytical chemistry.

[57]  N J Heyer,et al.  Lung cancer in chromate-exposed aerospace workers. , 1996, Journal of occupational and environmental medicine.

[58]  Geoffrey G. Zhang,et al.  Impact of dose on lung ventilation change calculated from 4D-CT using deformable image registration in lung cancer patients treated with SBRT , 2015, Journal of Radiation Oncology.

[59]  Marek Piliarik,et al.  Surface plasmon resonance biosensor for parallelized detection of protein biomarkers in diluted blood plasma. , 2010, Biosensors & bioelectronics.

[60]  Mei Yang,et al.  A highly sensitive electrochemical DNA biosensor for rapid detection of CYFRA21-1, a marker of non-small cell lung cancer , 2015 .

[61]  M. S. Beck,et al.  Electromagnetic inductance tomography (EMT): sensor, electronics and image reconstruction algorithm for a system with a rotatable parallel excitation field , 1998 .

[62]  Ying Liu,et al.  MiR‐449c targets c‐Myc and inhibits NSCLC cell progression , 2013, FEBS letters.

[63]  G. Pfeifer,et al.  Second-hand smoke and human lung cancer. , 2008, The Lancet. Oncology.

[64]  Tarek Mekhail,et al.  Exhaled Breath Analysis with a Colorimetric Sensor Array for the Identification and Characterization of Lung Cancer , 2012, Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer.

[65]  Ailin Liu,et al.  Simple and effective label-free electrochemical immunoassay for carbohydrate antigen 19-9 based on polythionine-Au composites as enhanced sensing signals for detecting different clinical samples , 2017, International journal of nanomedicine.

[66]  Robert T. Eagan,et al.  Combination chemotherapy and radiation therapy in small cell carcinoma of the lung , 1973, Cancer.

[67]  Chien Chou,et al.  Diagnostic detection of human lung cancer-associated antigen using a gold nanoparticle-based electrochemical immunosensor. , 2010, Analytical chemistry.

[68]  Weiling Fu,et al.  A SPR biosensor based on signal amplification using antibody-QD conjugates for quantitative determination of multiple tumor markers , 2016, Scientific reports.

[69]  Kevin M. Johnson,et al.  Detection of Small Pulmonary Nodules with Ultrashort Echo Time Sequences in Oncology Patients by Using a PET/MR System. , 2016, Radiology.

[70]  Antoine Flahault,et al.  Baseline results of the Depiscan study: a French randomized pilot trial of lung cancer screening comparing low dose CT scan (LDCT) and chest X-ray (CXR). , 2007, Lung cancer.

[71]  P. Mazzone,et al.  Detection of lung cancer by sensor array analyses of exhaled breath. , 2005, American journal of respiratory and critical care medicine.

[72]  Nevzat Karabulut,et al.  Comparison of low-dose and standard-dose helical CT in the evaluation of pulmonary nodules , 2002, European Radiology.

[73]  Matthias Reimold,et al.  18F-FDG PET for assessment of therapy response and preoperative re-evaluation after neoadjuvant radio-chemotherapy in stage III non-small cell lung cancer , 2007, European Journal of Nuclear Medicine and Molecular Imaging.

[74]  Chong-Jen Yu,et al.  GM2-Activator Protein: A New Biomarker for Lung Cancer , 2015, Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer.

[75]  Douglas K Owens,et al.  Test performance of positron emission tomography and computed tomography for mediastinal staging in patients with non-small-cell lung cancer: a meta-analysis. , 2003, Annals of internal medicine.

[76]  Huijuan Jiang,et al.  Tumor M2 pyruvate kinase in diagnosis of nonsmall cell lung cancer: A meta-analysis based on Chinese population. , 2015, Journal of cancer research and therapeutics.

[77]  F Levi,et al.  European cancer mortality predictions for the year 2015: does lung cancer have the highest death rate in EU women? , 2015, Annals of oncology : official journal of the European Society for Medical Oncology.

[78]  Jin-Wei Jia,et al.  Clinical significance of annexin II expression in human non-small cell lung cancer , 2013, Tumor Biology.

[79]  Célia Lourenço,et al.  Breath Analysis in Disease Diagnosis: Methodological Considerations and Applications , 2014, Metabolites.

[80]  Jens Haueisen,et al.  Sensitivity Comparisons of Cylindrical and Hemi-Spherical Coil Setups for Magnetic Induction Tomography , 2009 .

[81]  Ignacio I Wistuba,et al.  Lung Cancer Biomarkers. , 2017, Hematology/oncology clinics of North America.

[82]  G. Tricoles,et al.  Microwave holography: Applications and techniques , 1977, Proceedings of the IEEE.

[83]  Hermann Scharfetter,et al.  Planar gradiometer for magnetic induction tomography (MIT): theoretical and experimental sensitivity maps for a low-contrast phantom. , 2004, Physiological measurement.

[84]  C. Gatsonis,et al.  Reduced Lung-Cancer Mortality with Low-Dose Computed Tomographic Screening , 2012 .

[85]  Martín Mateo Mc,et al.  Serum copper, ceruloplasmin, lactic-dehydrogenase and alpha 2-globulin in lung cancer. , 1979 .

[86]  Wentao Yue,et al.  Label-free detection of p53 antibody using a microcantilever biosensor with piezoresistive readout , 2009, 2009 IEEE Sensors.

[87]  Yannick Crémillieux,et al.  Validation of simple and robust protocols for high‐resolution lung proton MRI in mice , 2010, Magnetic resonance in medicine.

[88]  Woon-Puay Koh,et al.  CYP2A6 genetic polymorphisms and biomarkers of tobacco smoke constituents in relation to risk of lung cancer in the Singapore Chinese Health Study , 2017, Carcinogenesis.

[89]  Takashi Isobe,et al.  Expression of α and β genes of human chorionic gonadotropin in lung cancer , 1997 .

[90]  Kevin Gleeson,et al.  Detection of lung cancer with volatile markers in the breath. , 2003, Chest.

[91]  Manuchehr Soleimani,et al.  Experimental evaluation of conductive flow imaging using magnetic induction tomography , 2015 .

[92]  Weiling Song,et al.  Ultrasensitive detection of nucleic acids and proteins using quartz crystal microbalance and surface plasmon resonance sensors based on target-triggering multiple signal amplification strategy. , 2017, Analytica chimica acta.

[93]  Bin He,et al.  Magnetoacoustic imaging of human liver tumor with magnetic induction. , 2011, Applied physics letters.

[94]  D. Naidich,et al.  Evaluation of individuals with pulmonary nodules: when is it lung cancer? Diagnosis and management of lung cancer, 3rd ed: American College of Chest Physicians evidence-based clinical practice guidelines. , 2013, Chest.

[95]  N. Peled,et al.  Exhaled breath analysis for the early detection of lung cancer: recent developments and future prospects , 2017, Lung Cancer.

[96]  Hermann Scharfetter,et al.  Optimum Receiver Array Design for Magnetic Induction Tomography , 2009, IEEE Transactions on Biomedical Engineering.

[97]  R. Stephens,et al.  Unique microRNA molecular profiles in lung cancer diagnosis and prognosis. , 2006, Cancer cell.

[98]  Vicky Goh,et al.  Quantifying tumour heterogeneity in 18F-FDG PET/CT imaging by texture analysis , 2012, European Journal of Nuclear Medicine and Molecular Imaging.

[99]  Yanjun Dong,et al.  Serum carcinoembryonic antigen, neuron-specific enolase as biomarkers for diagnosis of nonsmall cell lung cancer. , 2016, Journal of cancer research and therapeutics.

[100]  E. Mark,et al.  p16(INK4a) and histology-specific methylation of CpG islands by exposure to tobacco smoke in non-small cell lung cancer. , 2001, Cancer research.

[101]  D. Aberle,et al.  Results of initial low-dose computed tomographic screening for lung cancer. , 2013, The New England journal of medicine.

[102]  A. Żywica,et al.  Magnetoacoustic tomography with magnetic induction for biological tissue imaging: numerical modelling and simulations , 2016 .

[103]  Johan Alexander Huisman,et al.  Three‐dimensional imaging of subsurface structural patterns using quantitative large‐scale multiconfiguration electromagnetic induction data , 2014 .

[104]  C. Zettler,et al.  p53 and Bcl-2 protein expression and its relationship with prognosis in small-cell lung cancer. , 2003, Clinical lung cancer.

[105]  Xu Qingle The application significance of serum CYFRA21-1 change in therapeutic efficacy monitoring of advanced stage NSCLC , 2013 .

[106]  L Räf,et al.  [Early diagnosis of breast cancer]. , 1979, Lakartidningen.

[107]  David Binns,et al.  The use of fused PET/CT images for patient selection and radical radiotherapy target volume definition in patients with non-small cell lung cancer: results of a prospective study with mature survival data. , 2013, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.

[108]  Koichi Abe,et al.  Electrochemical Detection of Vascular Endothelial Growth Factor with Aptamer Sandwich , 2012 .

[109]  M. Ruiz-Argüello,et al.  A New Biomarker Panel in Bronchoalveolar Lavage for an Improved Lung Cancer Diagnosis , 2014, Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer.

[110]  S. Dacic,et al.  Molecular Prognostic Markers of Lung Cancer , 2012 .

[111]  H Scharfetter,et al.  Sensitivity maps and system requirements for magnetic induction tomography using a planar gradiometer. , 2001, Physiological measurement.

[112]  Mustafa Kemal Sezgintürk,et al.  A new impedimetric biosensor utilizing VEGF receptor-1 (Flt-1): early diagnosis of vascular endothelial growth factor in breast cancer. , 2011, Biosensors & bioelectronics.

[113]  R. Cataneo,et al.  Volatile organic compounds in breath as markers of lung cancer: a cross-sectional study , 1999, The Lancet.

[114]  W P Bennett,et al.  Molecular epidemiology of human cancer risk: gene–environment interactions and p53 mutation spectrum in human lung cancer , 1999, The Journal of pathology.

[115]  D Gürsoy,et al.  Tracking of object movements for artefact suppression in Magnetic Induction Tomography (MIT) , 2010 .

[116]  Kazuo Sato,et al.  Diagnosis by Volatile Organic Compounds in Exhaled Breath from Lung Cancer Patients Using Support Vector Machine Algorithm , 2017, Sensors.

[117]  Shekhar Bhansali,et al.  Lung cancer and its early detection using biomarker-based biosensors. , 2011, Chemical reviews.

[118]  Yoshiharu Ohno,et al.  Ultra‐short echo time (UTE) MR imaging of the lung: Comparison between normal and emphysematous lungs in mutant mice , 2010, Journal of magnetic resonance imaging : JMRI.

[119]  N Taniguchi,et al.  Enzyme-linked immunosorbent assay for human manganese-containing superoxide dismutase and its content in lung cancer. , 1984, Journal of the National Cancer Institute.

[120]  R. W. Lau,et al.  The dielectric properties of biological tissues: III. Parametric models for the dielectric spectrum of tissues. , 1996, Physics in medicine and biology.

[121]  Omowunmi A Sadik,et al.  Immunosensors for quantifying cyclooxygenase 2 pain biomarkers. , 2011, Clinica chimica acta; international journal of clinical chemistry.

[122]  J. Biederer,et al.  Analysis of artefacts and detail resolution of lung MRI with breath-hold T1-weighted gradient-echo and T2-weighted fast spin-echo sequences with respiratory triggering , 2002, European Radiology.

[123]  Ming-Shyan Huang,et al.  Important prognostic factors for the long-term survival of lung cancer subjects in Taiwan , 2008, BMC Cancer.

[124]  H. Brisse,et al.  Comment on: Are the studies on cancer risk from CT scans biased by indication? Elements of answer from a large-scale cohort study in France , 2015, British Journal of Cancer.

[125]  Luke P. Lee,et al.  Single-step nanoplasmonic VEGF165 aptasensor for early cancer diagnosis. , 2012, ACS nano.

[126]  Jiro Ishida,et al.  A case of primary lung cancer lesion demonstrated by F-18 FDG positron emission tomography/computed tomography (PET/CT) one year after the detection of metastatic brain tumor. , 2011, Oncology letters.

[127]  Irina Kusmartseva,et al.  Panel of serum biomarkers for the diagnosis of lung cancer. , 2007, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[128]  Joshua Dajac,et al.  To Screen or not to Screen: Low Dose Computed Tomography in Comparison to Chest Radiography or Usual Care in Reducing Morbidity and Mortality from Lung Cancer , 2016, Cureus.

[129]  O Dössel,et al.  Design and performance of a planar-array MIT system with normal sensor alignment. , 2005, Physiological measurement.

[130]  Lixing Weng,et al.  Early Lung Cancer Diagnosis by Biosensors , 2013, International journal of molecular sciences.

[131]  Ugo Pastorino,et al.  Computed tomography screening and lung cancer outcomes. , 2007, JAMA.

[132]  J. Downward Targeting RAS signalling pathways in cancer therapy , 2003, Nature Reviews Cancer.

[133]  Subhashini Yaturu,et al.  Metastases to the Thyroid Presenting as a Metabolically Inactive Incidental Thyroid Nodule with Stable Size in 15 Months , 2014, Case reports in endocrinology.

[134]  R. W. Lau,et al.  The dielectric properties of biological tissues: II. Measurements in the frequency range 10 Hz to 20 GHz. , 1996, Physics in medicine and biology.

[135]  S. Tumański Induction coil sensors—a review , 2007 .

[136]  John K. Wiencke,et al.  p16INK4a and Histology-specific Methylation of CpG Islands by Exposure to Tobacco Smoke in Non-Small Cell Lung Cancer , 2001 .

[137]  Yang Zhou,et al.  Neuron-specific enolase, histopathological types, and age as risk factors for bone metastases in lung cancer , 2017, Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine.

[138]  Xiaoying Wang,et al.  Sensitive detection of p53 tumor suppressor gene using an enzyme-based solid-state electrochemiluminescence sensing platform. , 2011, Biosensors & bioelectronics.

[139]  Thomas Beyer,et al.  PET/CT is a cost-effective tool against cancer: synergy supersedes singularity , 2016, European Journal of Nuclear Medicine and Molecular Imaging.

[140]  Li-Li Zhu,et al.  CYFRA21-1 as a serum tumor marker for follow-up patients with squamous cell lung carcinoma and oropharynx squamous cell carcinoma. , 2013, Biomarkers in medicine.

[141]  Byung-Tae Kim,et al.  Non-small cell lung cancer: prospective comparison of integrated FDG PET/CT and CT alone for preoperative staging. , 2005, Radiology.

[142]  P. Efron,et al.  Effects of trauma , hemorrhagic shock , and chronic stress on lung VEGF , 2017 .

[143]  Davide Ippolito,et al.  Feasibility of perfusion CT technique integrated into conventional 18FDG/PET-CT studies in lung cancer patients: clinical staging and functional information in a single study , 2012, European Journal of Nuclear Medicine and Molecular Imaging.

[144]  H Griffiths,et al.  Magnetic induction tomography: phase versus vector-voltmeter measurement techniques , 2003, Physiological measurement.

[145]  Tarek Mekhail,et al.  Diagnosis of lung cancer by the analysis of exhaled breath with a colorimetric sensor array , 2007, Thorax.

[146]  W. Boireau,et al.  Surface plasmon resonance imaging in arrays coupled with mass spectrometry (SUPRA–MS): proof of concept of on-chip characterization of a potential breast cancer marker in human plasma , 2012, Analytical and Bioanalytical Chemistry.

[147]  Qing Lan,et al.  Genetic variation in telomere maintenance genes, telomere length, and lung cancer susceptibility. , 2009, Lung cancer.

[148]  Xianting Ding,et al.  Electrochemical detection of lung cancer specific microRNAs using 3D DNA origami nanostructures. , 2015, Biosensors & bioelectronics.

[149]  Mojtaba Shamsipur,et al.  A high sensitive electrochemical aptasensor for the determination of VEGF(165) in serum of lung cancer patient. , 2015, Biosensors & bioelectronics.

[150]  H Griffiths,et al.  A highly phase-stable differential detector amplifier for magnetic induction tomography. , 2011, Physiological measurement.

[151]  H. Lackner,et al.  Magnetic induction tomography: hardware for multi-frequency measurements in biological tissues. , 2001, Physiological measurement.

[152]  M C Martin Mateo,et al.  Serum copper, ceruloplasmin, lactic-dehydrogenase and alpha 2-globulin in lung cancer. , 1979, Biomedicine / [publiee pour l'A.A.I.C.I.G.].

[153]  A. A. Modestov,et al.  Electrochemical aptasensor for lung cancer-related protein detection in crude blood plasma samples , 2016, Scientific Reports.

[154]  Manuchehr Soleimani,et al.  Theoretical and Experimental Evaluation of Rotational Magnetic Induction Tomography , 2012, IEEE Transactions on Instrumentation and Measurement.

[155]  Hans-Ulrich Kauczor,et al.  Lung MRI at 1.5 and 3 Tesla: Observer Preference Study and Lesion Contrast Using Five Different Pulse Sequences , 2007, Investigative radiology.

[156]  V Kalff,et al.  F‐18 fluorodeoxyglucose positron emission tomography staging in radical radiotherapy candidates with nonsmall cell lung carcinoma , 2001, Cancer.

[157]  Kazuya Kondo,et al.  The reduced expression and aberrant methylation of p16(INK4a) in chromate workers with lung cancer. , 2005, Lung cancer.

[158]  W. Hsu,et al.  Role of preoperative PET‐CT in assessing mediastinal and hilar lymph node status in early stage lung cancer , 2012, Journal of the Chinese Medical Association : JCMA.

[159]  Patricia Brunner,et al.  Solution of the inverse problem of magnetic induction tomography (MIT) , 2005, Physiological measurement.

[160]  H. Haick,et al.  Sensors for breath testing: from nanomaterials to comprehensive disease detection. , 2014, Accounts of chemical research.

[161]  A. Dirksen,et al.  CT screening for lung cancer brings forward early disease. The randomised Danish Lung Cancer Screening Trial: status after five annual screening rounds with low-dose CT , 2012, Thorax.

[162]  P. Thompson,et al.  Expression of tissue and plasma kallikreins and kinin B1 and B2 receptors in lung cancer , 2008, Biological chemistry.

[163]  P. Mazzone,et al.  Analysis of volatile organic compounds in the exhaled breath for the diagnosis of lung cancer. , 2008, Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer.

[164]  N. Thacker,et al.  Quantifying heterogeneity in human tumours using MRI and PET. , 2012, European journal of cancer.

[165]  Hermann Scharfetter,et al.  A new type of gradiometer for the receiving circuit of magnetic induction tomography (MIT). , 2005, Physiological measurement.

[166]  Guangshun Wang,et al.  Serum cyfra21-1 as a biomarker in patients with nonsmall cell lung cancer. , 2014, Journal of cancer research and therapeutics.

[167]  Nevzat G. Gencer,et al.  Electrical conductivity imaging via contactless measurements: an experimental study , 2003, IEEE Transactions on Medical Imaging.

[168]  Raffaele Velotta,et al.  Effective antibodies immobilization and functionalized nanoparticles in a quartz-crystal microbalance-based immunosensor for the detection of parathion , 2017, PloS one.

[169]  A. Stromberg,et al.  Profiling Tumor-Associated Antibodies for Early Detection of Non-small Cell Lung Cancer , 2006, Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer.

[170]  Xuguo Sun,et al.  Transthyretin as a potential biomarker for the differential diagnosis between lung cancer and lung infection. , 2014, Biomedical reports.

[171]  S. Stuckey,et al.  Proton Density MRI Increases Detection of Cervical Spinal Cord Multiple Sclerosis Lesions Compared with T2-Weighted Fast Spin-Echo , 2016, American Journal of Neuroradiology.

[172]  John Clarke,et al.  Superconducting thin‐film gradiometer , 1978 .

[173]  C H Igney,et al.  A measurement system and image reconstruction in magnetic induction tomography. , 2008, Physiological measurement.

[174]  Valentina Donzella,et al.  Optical biosensors to analyze novel biomarkers in oncology , 2011, Journal of biophotonics.

[175]  Rong Liu,et al.  Alteration of serum miR-206 and miR-133b is associated with lung carcinogenesis induced by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone. , 2013, Toxicology and applied pharmacology.

[176]  R. Stolz,et al.  LTS SQUID sensor with a new configuration , 1999 .

[177]  Suyan Tian,et al.  Identification of differentially-expressed genes between early-stage adenocarcinoma and squamous cell carcinoma lung cancer using meta-analysis methods. , 2017, Oncology letters.

[178]  C. Pérez,et al.  PET-CT in presurgical lymph node staging in non-small cell lung cancer: the importance of false-negative and false-positive findings. , 2017, Radiologia.

[179]  Ian O. Ellis,et al.  Immunoglobulin free light chains are biomarkers of poor prognosis in basal-like breast cancer and are potential targets in tumor-associated inflammation , 2014, Oncotarget.

[180]  Lorraine Wilson,et al.  Lymph node staging by means of positron emission tomography is less accurate in non-small cell lung cancer patients with enlarged lymph nodes: analysis of 1,145 lymph nodes. , 2008, Lung cancer.

[181]  Sazali Yaacob,et al.  Advancements in Transmitters and Sensors for Biological Tissue Imaging in Magnetic Induction Tomography , 2012, Sensors.

[182]  Yasar Gurbuz,et al.  A novel magnetic particle-modified electrochemical sensor for immunosensor applications , 2012 .

[183]  M Groth,et al.  Intraindividual comparison of contrast-enhanced MRI and unenhanced SSFP sequences of stenotic and non-stenotic pulmonary artery diameters. , 2011, RoFo : Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin.

[184]  Wei He,et al.  A multi-channel magnetic induction tomography measurement system for human brain model imaging. , 2009, Physiological measurement.

[185]  Abhishek Mahajan,et al.  ALK Positive Lung Cancer: Clinical Profile, Practice and Outcomes in a Developing Country , 2016, PloS one.

[186]  Oliver Sedlaczek,et al.  Modern diagnostic and therapeutic interventional radiology in lung cancer. , 2013, Journal of thoracic disease.

[187]  C. Caucheteur,et al.  Cancer biomarker sensing using packaged plasmonic optical fiber gratings: Towards in vivo diagnosis. , 2017, Biosensors & bioelectronics.

[188]  Francesca Pentimalli,et al.  Mass spectrometry-based proteomics: the road to lung cancer biomarker discovery. , 2013, Mass spectrometry reviews.

[189]  Ugo Pastorino,et al.  Annual or biennial CT screening versus observation in heavy smokers: 5-year results of the MILD trial , 2012, European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation.

[190]  工藤 博幸 低被曝CTにおける画像再構成法:―統計的画像再構成,逐次近似画像再構成,圧縮センシングの基礎― , 2014 .

[191]  M. Komorowski,et al.  A New Transducer for Magnetic Induction Tomography , 2009, IEEE Transactions on Magnetics.

[192]  Somayeh Heydari,et al.  Application of Nanoparticles in Quartz Crystal Microbalance Biosensors , 2014 .

[193]  Hong Qiu,et al.  Clinical utility of haptoglobin in combination with CEA, NSE and CYFRA21-1 for diagnosis of lung cancer. , 2014, Asian Pacific journal of cancer prevention : APJCP.

[194]  Joachim Schneider,et al.  Pro-gastrin-releasing peptide (ProGRP), neuron specific enolase (NSE), carcinoembryonic antigen (CEA) and cytokeratin 19-fragments (CYFRA 21-1) in patients with lung cancer in comparison to other lung diseases. , 2003, Anticancer research.

[195]  Shulin Zhao,et al.  Noncompetitive immunoassay for carcinoembryonic antigen in human serum by microchip electrophoresis for cancer diagnosis. , 2010, Clinica chimica acta; international journal of clinical chemistry.