A high‐voltage stimulation chip for wearable stroke rehabilitation systems

Summary In this work, an 8-channel high-voltage (HV) stimulation chip for the rehabilitation of stroke patients through surface stimulation is presented. The chip receives control data through its serial peripheral interface and can be controlled by an external microcontroller. It can accordingly generate biphasic stimulation currents with different amplitudes, duration time, frequencies, and polarities for each channel independently. The chip was designed and fabricated using X-FAB 0.35 µm HV mixed-signal process. Circuits were carefully designed to ensure their operations under HVs. Our measurement results showed that a supply voltage of as high as 75 V can be achieved, and the current driver can generate biphasic stimuli with current amplitudes up to 4 mA. Copyright © 2015 John Wiley & Sons, Ltd.

[1]  Ting Wang,et al.  Development of a network FES system for stroke rehabilitation , 2011, 2011 Annual International Conference of the IEEE Engineering in Medicine and Biology Society.

[2]  H. van der Kooij,et al.  Selectivity and Resolution of Surface Electrical Stimulation for Grasp and Release , 2012, IEEE Transactions on Neural Systems and Rehabilitation Engineering.

[3]  Y. M. Mustafah,et al.  The design of non-invasive functional electrical stimulation (FES) for restoration of muscle function , 2012, 2012 International Conference on Computer and Communication Engineering (ICCCE).

[4]  J. Weiland,et al.  A variable range bi-phasic current stimulus driver circuitry for an implantable retinal prosthetic device , 2005, IEEE Journal of Solid-State Circuits.

[5]  M R Popovic,et al.  Surface-stimulation technology for grasping and walking neuroprosthesis. , 2001, IEEE engineering in medicine and biology magazine : the quarterly magazine of the Engineering in Medicine & Biology Society.

[6]  Chun-Yu Lin,et al.  Implantable Stimulator for Epileptic Seizure Suppression With Loading Impedance Adaptability , 2013, IEEE Transactions on Biomedical Circuits and Systems.

[7]  Nigel H. Lovell,et al.  Design of Safe Two-Wire Interface-Driven Chip-Scale Neurostimulator for Visual Prosthesis , 2013, IEEE Journal of Solid-State Circuits.

[8]  Herman van der Kooij,et al.  Grasp and release with surface functional electrical stimulation using a Model Predictive Control approach , 2012, 2012 Annual International Conference of the IEEE Engineering in Medicine and Biology Society.

[9]  Edward K. F. Lee,et al.  A 36V biphasic stimulator with electrode monitoring circuit , 2012, 2012 IEEE International Symposium on Circuits and Systems.

[10]  Luigi Raffo,et al.  An HV-CMOS Integrated Circuit for Neural Stimulation in Prosthetic Applications , 2015, IEEE Transactions on Circuits and Systems II: Express Briefs.

[11]  Mohamad Sawan,et al.  Exponential Current Pulse Generation for Efficient Very High-Impedance Multisite Stimulation , 2011, IEEE Transactions on Biomedical Circuits and Systems.

[12]  N. Sims,et al.  Mitochondria, oxidative metabolism and cell death in stroke. , 2010, Biochimica et biophysica acta.

[13]  Wentai Liu,et al.  Closed-loop eyelid reanimation system with real-time blink detection and electrochemical stimulation for facial nerve paralysis , 2009, 2009 IEEE International Symposium on Circuits and Systems.

[14]  G. Ocadiz,et al.  Programmable eight channel surface stimulator , 1994, Proceedings of 16th Annual International Conference of the IEEE Engineering in Medicine and Biology Society.

[15]  Manfred Morari,et al.  Grasping and walking neuroprostheses for stroke and spinal cord injured subjects , 1999, Proceedings of the 1999 American Control Conference (Cat. No. 99CH36251).

[16]  Jianfei Jiang,et al.  Design of a high voltage stimulator chip for a stroke rehabilitation system , 2013, 2013 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC).

[17]  Timothy G. Constandinou,et al.  An Energy-Efficient, Dynamic Voltage Scaling Neural Stimulator for a Proprioceptive Prosthesis , 2012, IEEE Transactions on Biomedical Circuits and Systems.

[18]  Chua-Chin Wang,et al.  One-Time Implantable SCS System , 2011, 2011 5th International Conference on Bioinformatics and Biomedical Engineering.

[19]  Chun-Yu Lin,et al.  High-voltage-tolerant stimulator with adaptive loading consideration for electronic epilepsy prosthetic SoC in a 0.18-µm CMOS process , 2012, 10th IEEE International NEWCAS Conference.

[20]  Naoto Shiba,et al.  Surface electrical stimulation to realize task oriented hand motion , 2009, 2009 Annual International Conference of the IEEE Engineering in Medicine and Biology Society.

[21]  C. L. Doren,et al.  A high voltage, constant current stimulator for electrocutaneous stimulation through small electrodes , 1999, IEEE Transactions on Biomedical Engineering.

[22]  N. Hoshimiya,et al.  A multichannel FES system for the restoration of motor functions in high spinal cord injury patients: a respiration-controlled system for multijoint upper extremity , 1989, IEEE Transactions on Biomedical Engineering.

[23]  Andreas Demosthenous,et al.  An Integrated Implantable Stimulator That is Fail-Safe Without Off-Chip Blocking-Capacitors , 2008, IEEE Transactions on Biomedical Circuits and Systems.