The Cellular Basis of Hepatic Fibrosis -- Mechanisms and Treatment Strategies

Hepatic fibrosis is a common response to chronic liver injury from many causes, including alcohol, persistent viral and helminthic infections, and hereditary metal overload. Emerging evidence suggests that cellular mechanisms of hepatic fibrosis are shared among these different insults and, moreover, that the liver's response is a paradigm for parenchymal wound healing in other tissues. Advances in the isolation and characterization of liver cells, in conjunction with progress in matrix and cytokine biology, have led to important new insights about the cellular basis of hepatic fibrosis. In particular, the hepatic lipocyte (also known as the stellate, fat-storing, perisinusoidal, or Ito . . .

[1]  E. Ruoslahti,et al.  Natural inhibitor of transforming growth factor-β protects against scarring in experimental kidney disease , 1992, Nature.

[2]  A. Gressner,et al.  Identification and partial characterization of a hepatocyte‐derived factor promoting proliferation of cultured fat‐storing cells (parasinusoidal lipocytes) , 1992, Hepatology.

[3]  M. Odenthal,et al.  Synthesis of cellular fibronectin by rat liver fat-storing (Ito) cells: regulation by cytokines. , 1992, Gastroenterology.

[4]  S. Friedman,et al.  Inhibition of rat hepatic lipocyte activation in culture by interferon‐γ , 1992, Hepatology.

[5]  M. Siegman,et al.  Elimination of smooth muscle cells in experimental restenosis: targeting of fibroblast growth factor receptors. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[6]  E. Baldi,et al.  Fat-storing cells as liver-specific pericytes. Spatial dynamics of agonist-stimulated intracellular calcium transients. , 1992, The Journal of clinical investigation.

[7]  B. Bacon,et al.  Increased 4‐hydroxynonenal levels in experimental alcoholic liver disease: Association of lipid peroxidation with liver fibrogenesis , 1992, Hepatology.

[8]  N. Kawada,et al.  Eicosanoid-mediated contractility of hepatic stellate cells. , 1992, The Biochemical journal.

[9]  S. Friedman,et al.  Human hepatic lipocytes synthesize tissue inhibitor of metalloproteinases-1. Implications for regulation of matrix degradation in liver. , 1992, The Journal of clinical investigation.

[10]  A. Gressner,et al.  Biglycan and decorin gene expression in normal and fibrotic rat liver: Cellular localization and regulatory factors , 1992, Hepatology.

[11]  M. Odenthal,et al.  Alternative splicing products of the tenascin gene distinguish rat liver fat storing cells from arterial smooth muscle cells and skin fibroblasts. , 1992, Biochemical and biophysical research communications.

[12]  R. F. McGuire,et al.  Role of extracellular matrix in regulating fenestrations of sinusoidal endothelial cells isolated from normal rat liver , 1992, Hepatology.

[13]  A. Burt,et al.  Macrophage and perisinusoidal cell kinetics in acute liver injury , 1992, The Journal of pathology.

[14]  D. Schuppan,et al.  Distribution and cellular origin of collagen VI during development and in cirrhosis. , 1992, Gastroenterology.

[15]  Cho-il Kim,et al.  Polyunsaturated lecithin prevents acetaldehyde‐mediated hepatic collagen accumulation by stimulating collagenase activity in cultured lipocytes , 1992, Hepatology.

[16]  S. Friedman.  “Cuts both ways”: Collagenases, lipocyte activation and polyunsaturated lecithin , 1992, Hepatology.

[17]  G. Cairo,et al.  Regulation of transferrin, transferrin receptor, and ferritin genes in human duodenum. , 1992, Gastroenterology.

[18]  S. Friedman,et al.  Isolated hepatic lipocytes and kupffer cells from normal human liver: Morphological and functional characteristics in primary culture , 1992, Hepatology.

[19]  K. Nakanishi,et al.  Intracellular signaling by 14-hydroxy-4,14-retro-retinol. , 1991, Science.

[20]  A. Guillouzo,et al.  Differential expression of laminin chains in hepatic lipocytes , 1991, FEBS letters.

[21]  M. Reidy,et al.  Inhibition of neointimal smooth muscle accumulation after angioplasty by an antibody to PDGF , 1991, Science.

[22]  A. Gown,et al.  Platelet-derived growth factor (PDGF) and PDGF receptor are induced in mesangial proliferative nephritis in the rat. , 1991, Proceedings of the National Academy of Sciences of the United States of America.

[23]  E. Wisse,et al.  Tissue distribution, quantitation and proliferation kinetics of fat‐storing cells in carbon tetrachloride–injured rat liver , 1991, Hepatology.

[24]  A. Geubel,et al.  Liver damage caused by therapeutic vitamin A administration: estimate of dose-related toxicity in 41 cases. , 1991, Gastroenterology.

[25]  C. Lieber,et al.  Acetaldehyde increases procollagen type I and fibronectin gene transcription in cultured rat fat‐storing cells through a protein synthesis–dependent mechanism , 1991, Hepatology.

[26]  N. Davidson,et al.  Retinoic acid modulates rat Ito cell proliferation, collagen, and transforming growth factor beta production. , 1990, The Journal of clinical investigation.

[27]  M. Filip,et al.  Malondialdehyde and 4-hydroxynonenal protein adducts in plasma and liver of rats with iron overload. , 1990, The Journal of clinical investigation.

[28]  R. F. McGuire,et al.  Extracellular matrix gene expression increases preferentially in rat lipocytes and sinusoidal endothelial cells during hepatic fibrosis in vivo. , 1990, The Journal of clinical investigation.

[29]  S. Friedman.  Acetaldehyde and alcoholic fibrogenesis: Fuel to the fire, but not the spark , 1990, Hepatology.

[30]  K. Tanikawa,et al.  Immunohistochemistry of the hepatic extracellular matrix in acute viral hepatitis , 1990, Hepatology.

[31]  S. Thorgeirsson,et al.  Cellular distribution of transforming growth factor-beta 1 and procollagen types I, III, and IV transcripts in carbon tetrachloride-induced rat liver fibrosis. , 1990, The Journal of clinical investigation.

[32]  H. Tsukamoto,et al.  Stimulation of hepatic lipocyte collagen production by Kupffer cell‐derived transforming growth factor β: Implication for a pathogenetic role in alcoholic liver fibrogenesis , 1990, Hepatology.

[33]  Gressner Am,et al.  Cellular sources of noncollagenous matrix proteins: role of fat-storing cells in fibrogenesis. , 1990 .

[34]  S. Friedman.  Cellular Sources of Collagen and Regulation of Collagen Production in Liver , 1990, Seminars in liver disease.

[35]  L. Gesualdo,et al.  Effects of platelet-derived growth factor and other polypeptide mitogens on DNA synthesis and growth of cultured rat liver fat-storing cells. , 1989, The Journal of clinical investigation.

[36]  S. Friedman,et al.  Activation of cultured rat hepatic lipocytes by Kupffer cell conditioned medium. Direct enhancement of matrix synthesis and stimulation of cell proliferation via induction of platelet-derived growth factor receptors. , 1989, The Journal of clinical investigation.

[37]  D. Brenner,et al.  Stimulation of collagen gene expression by ascorbic acid in cultured human fibroblasts. A role for lipid peroxidation? , 1989, The Journal of biological chemistry.

[38]  M. Abecassis,et al.  Biochemical and clinical response of fulminant viral hepatitis to administration of prostaglandin E. A preliminary report. , 1989, The Journal of clinical investigation.

[39]  S. Friedman,et al.  Lipocytes from normal rat liver release a neutral metalloproteinase that degrades basement membrane (type IV) collagen. , 1989, The Journal of clinical investigation.

[40]  S. Friedman,et al.  Maintenance of differentiated phenotype of cultured rat hepatic lipocytes by basement membrane matrix. , 1989, The Journal of biological chemistry.

[41]  W. Bursch,et al.  Histochemical and biochemical studies on the effect of the prostacyclin derivative iloprost on CCI4‐induced lipid peroxidation in rat liver and its significance for hepatoprotection , 1989, Hepatology.

[42]  H. Stein,et al.  Cellular localization of laminin gene transcripts in normal and fibrotic human liver. , 1989, The American journal of pathology.

[43]  P. Greenwel,et al.  Kupffer cells from CC1(4)-treated rat livers induce skin fibroblast and liver fat-storing cell proliferation in culture. , 1989, Matrix.

[44]  A. Ooshima,et al.  Collagen production in fat-storing cells after carbon tetrachloride intoxication in the rat. Immunoelectron microscopic observation of type I, type III collagens, and prolyl hydroxylase. , 1988, Laboratory investigation; a journal of technical methods and pathology.

[45]  S. Friedman,et al.  Formation of extracellular matrix in normal rat liver: lipocytes as a major source of proteoglycan. , 1988, Gastroenterology.

[46]  M. Gent,et al.  Colchicine in the treatment of cirrhosis of the liver. , 1988, The New England journal of medicine.

[47]  C. Heldin,et al.  INDUCTION OF B-TYPE RECEPTORS FOR PLATELET-DERIVED GROWTH FACTOR IN VASCULAR INFLAMMATION: POSSIBLE IMPLICATIONS FOR DEVELOPMENT OF VASCULAR PROLIFERATIVE LESIONS , 1988, The Lancet.

[48]  S. Friedman,et al.  Immunolocalization of laminin in normal rat liver and biosynthesis of laminin by hepatic lipocytes in primary culture. , 1988, Gastroenterology.

[49]  C. Heldin,et al.  Expression of Platelet‐Derived Growth Factor Receptors is Induced on Connective Tissue Cells During Chronic Synovial Inflammation , 1988, Scandinavian journal of immunology.

[50]  B. Davis,et al.  Retinol and extracellular collagen matrices modulate hepatic Ito cell collagen phenotype and cellular retinol binding protein levels. , 1987, The Journal of biological chemistry.

[51]  J. Maher,et al.  Support of cultured hepatocytes by a laminin-rich gel. Evidence for a functionally significant subendothelial matrix in normal rat liver. , 1987, The Journal of clinical investigation.

[52]  S. Friedman,et al.  Hepatic lipocytes: the principal collagen-producing cells of normal rat liver. , 1985, Proceedings of the National Academy of Sciences of the United States of America.

[53]  A. Sonnenberg,et al.  Survival and causes of death in cirrhotic and in noncirrhotic patients with primary hemochromatosis. , 1985, The New England journal of medicine.

[54]  A. Martinez‐Hernandez.  The hepatic extracellular matrix. II. Electron immunohistochemical studies in rats with CCl4-induced cirrhosis. , 1985, Laboratory investigation; a journal of technical methods and pathology.

[55]  Sumio Watanabe,et al.  Immunocytochemical Detection of Desmin in Fat‐Storing Cells (Ito Cells) , 1984, Hepatology.

[56]  C. Lieber,et al.  Hepatic vitamin A depletion in alcoholic liver injury. , 1982, The New England journal of medicine.

[57]  S. Pocock,et al.  Late results of the Royal Free Hospital prospective controlled trial of prednisolone therapy in hepatitis B surface antigen negative chronic active hepatitis. , 1980, Gut.

[58]  M Rojkind,et al.  Collagen types in normal and cirrhotic liver. , 1979, Gastroenterology.

[59]  I. Sternlieb,et al.  Prevention of Wilson's disease in asymptomatic patients. , 1968, The New England journal of medicine.

[60]  H. Popper,et al.  Capillarization of hepatic sinusoids in man. , 1963, Gastroenterology.

[61]  A. Gressner,et al.  Activation of rat liver perisinusoidal lipocytes by transforming growth factors derived from myofibroblastlike cells. A potential mechanism of self perpetuation in liver fibrogenesis. , 1992, The Journal of clinical investigation.

[62]  R. Hultcrantz,et al.  Iron mediates production of a neutrophil chemoattractant by rat hepatocytes metabolizing ethanol. , 1991, The Journal of clinical investigation.

[63]  C. Lieber.  Interaction of ethanol with drugs, hepatotoxic agents, carcinogens and vitamins. , 1990, Alcohol and alcoholism.

[64]  T. Veit,et al.  Expression of the gene of the α-smooth muscle-actin isoform in rat liver and in rat fat-storing (ITO) cells , 1990, Virchows Archiv. B, Cell pathology including molecular pathology.

[65]  E. Wisse,et al.  Kupffer cells from CCl4-induced fibrotic livers stimulate proliferation of fat-storing cells. , 1986, Journal of hepatology.