Influence of Medial and Adventitial Layer on Arterial Adaptation

Material properties in general and layer-specific stiffness in particular are critical factors to predict the initiation and growth of aneurysms. Previous experimental studies show vastly differing material stiffness and metabolic activity in the media and the adventitia. In this paper a phenomenological model using FEM is applied in order to predict the adaptive response of the arterial wall in different mechanical and metabolic cases. (© 2010 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim)