APPL1 Potentiates Insulin Sensitivity by Facilitating the Binding of IRS1/2 to the Insulin Receptor
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Feng Dong | Steven N. Austad | Feng Liu | Muhammad A. Abdul-Ghani | Ralph A. DeFronzo | F. Liu | R. DeFronzo | S. Austad | M. White | Shaodong Guo | N. Musi | J. Ryu | Amanda K. Galan | Xiaoban Xin | Feng Dong | M. Abdul-Ghani | Lijun Zhou | Changhua Wang | Cuiling Li | Bekke M. Holmes | L. Sloane | C. Deng | Lily Q. Dong | Jiyoon Ryu | Morris F. White | Nicolas Musi | Chuxia Deng | Changhua Wang | Shaodong Guo | Xiaoban Xin | Lijun Zhou | Cuiling Li | Lauren B. Sloane | Feng Liu | L. Dong
[1] W. Jia,et al. Deficiency of APPL1 in mice impairs glucose-stimulated insulin secretion through inhibition of pancreatic beta cell mitochondrial function , 2013, Diabetologia.
[2] A. Xu,et al. APPL1 Counteracts Obesity-Induced Vascular Insulin Resistance and Endothelial Dysfunction by Modulating the Endothelial Production of Nitric Oxide and Endothelin-1 in Mice , 2011, Diabetes.
[3] Y. Kalaidzidis,et al. Biochemical Characterization of APPL Endosomes: The Role of Annexin A2 in APPL Membrane Recruitment , 2011, Traffic.
[4] R. Berria,et al. Increased abundance of the adaptor protein containing pleckstrin homology domain, phosphotyrosine binding domain and leucine zipper motif (APPL1) in patients with obesity and type 2 diabetes: evidence for altered adiponectin signalling , 2011, Diabetologia.
[5] N. Turner,et al. The adaptor protein APPL1 increases glycogen accumulation in rat skeletal muscle through activation of the PI3-kinase signalling pathway , 2011, The Journal of endocrinology.
[6] M. Birnbaum,et al. Receptor-mediated activation of ceramidase activity initiates the pleiotropic actions of adiponectin , 2011, Nature Medicine.
[7] F. Liu,et al. APPL1 mediates adiponectin-stimulated p38 MAPK activation by scaffolding the TAK1-MKK3-p38 MAPK pathway. , 2011, American journal of physiology. Endocrinology and metabolism.
[8] F. Thong,et al. An APPL1-AMPK signaling axis mediates beneficial metabolic effects of adiponectin in the heart. , 2010, American journal of physiology. Endocrinology and metabolism.
[9] J. Testa,et al. Appl1 is dispensable for Akt signaling in vivo and mouse T‐cell development , 2010, Genesis.
[10] A. Xu,et al. Appl1 is essential for the survival of Xenopus pancreas, duodenum, and stomach progenitor cells , 2010, Developmental dynamics : an official publication of the American Association of Anatomists.
[11] J. McLean,et al. Identification of phosphorylation sites within the signaling adaptor APPL1 by mass spectrometry. , 2010, Journal of proteome research.
[12] J. Testa,et al. Appl1 Is Dispensable for Mouse Development, and Loss of Appl1 Has Growth Factor-selective Effects on Akt Signaling in Murine Embryonic Fibroblasts* , 2009, The Journal of Biological Chemistry.
[13] Feng Liu,et al. Yin-Yang Regulation of Adiponectin Signaling by APPL Isoforms in Muscle Cells* , 2009, The Journal of Biological Chemistry.
[14] J. M. Torres,et al. Adiponectin Activates AMP-activated Protein Kinase in Muscle Cells via APPL1/LKB1-dependent and Phospholipase C/Ca2+/Ca2+/Calmodulin-dependent Protein Kinase Kinase-dependent Pathways* , 2009, The Journal of Biological Chemistry.
[15] E. Kraegen,et al. APPL1 potentiates insulin-mediated inhibition of hepatic glucose production and alleviates diabetes via Akt activation in mice. , 2009, Cell metabolism.
[16] D. Toomre,et al. A Phosphoinositide Switch Controls the Maturation and Signaling Properties of APPL Endosomes , 2009, Cell.
[17] Lily Q. Dong,et al. APPL1: role in adiponectin signaling and beyond. , 2009, American journal of physiology. Endocrinology and metabolism.
[18] C. Collinet,et al. The Endosomal Protein Appl1 Mediates Akt Substrate Specificity and Cell Survival in Vertebrate Development , 2008, Cell.
[19] M. Czech,et al. The Interaction of Akt with APPL1 Is Required for Insulin-stimulated Glut4 Translocation* , 2007, Journal of Biological Chemistry.
[20] G. Shulman,et al. Obesity-associated improvements in metabolic profile through expansion of adipose tissue. , 2007, The Journal of clinical investigation.
[21] F. Liu,et al. Peripheral Disruption of the Grb10 Gene Enhances Insulin Signaling and Sensitivity In Vivo , 2007, Molecular and Cellular Biology.
[22] D. Carling,et al. Adiponectin-Induced Endothelial Nitric Oxide Synthase Activation and Nitric Oxide Production Are Mediated by APPL1 in Endothelial Cells , 2007, Diabetes.
[23] F. Liu,et al. Adiponectin Sensitizes Insulin Signaling by Reducing p70 S6 Kinase-mediated Serine Phosphorylation of IRS-1* , 2007, Journal of Biological Chemistry.
[24] Feng Liu,et al. APPL1 binds to adiponectin receptors and mediates adiponectin signalling and function , 2006, Nature Cell Biology.
[25] C. Kahn,et al. Critical nodes in signalling pathways: insights into insulin action , 2006, Nature Reviews Molecular Cell Biology.
[26] J. Testa,et al. Human Follicle-Stimulating Hormone (FSH) Receptor Interacts with the Adaptor Protein APPL1 in HEK 293 Cells: Potential Involvement of the PI3K Pathway in FSH Signaling1 , 2004, Biology of reproduction.
[27] Bianca Habermann,et al. APPL Proteins Link Rab5 to Nuclear Signal Transduction via an Endosomal Compartment , 2004, Cell.
[28] Chawnshang Chang,et al. APPL Suppresses Androgen Receptor Transactivation via Potentiating Akt Activity* , 2003, The Journal of Biological Chemistry.
[29] Russell L Finley,et al. Mediation of the DCC Apoptotic Signal by DIP13α* , 2002, The Journal of Biological Chemistry.
[30] Y. Terauchi,et al. The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity , 2001, Nature Medicine.
[31] P. Roey,et al. HUMAN FOLLICLE STIMULATING HORMONE , 2001 .
[32] Erica A Golemis,et al. Identification of a chromosome 3p14.3-21.1 gene, APPL, encoding an adaptor molecule that interacts with the oncoprotein-serine/threonine kinase AKT2 , 1999, Oncogene.
[33] M. Rose. Follicle stimulating hormone international standards and reference preparations for the calibration of immunoassays and bioassays. , 1998, Clinica chimica acta; international journal of clinical chemistry.
[34] L. Dong,et al. Site-directed mutagenesis and yeast two-hybrid studies of the insulin and insulin-like growth factor-1 receptors: the Src homology-2 domain-containing protein hGrb10 binds to the autophosphorylated tyrosine residues in the kinase domain of the insulin receptor. , 1997, Molecular endocrinology.
[35] B Wang,et al. Insulin-induced in situ phosphorylation of the insulin receptor located in the plasma membrane versus endosomes. , 1996, Biochemical and biophysical research communications.
[36] J. Blenis,et al. YMXM motifs and signaling by an insulin receptor substrate 1 molecule without tyrosine phosphorylation sites , 1996, Molecular and cellular biology.
[37] P. Pilch,et al. Dynamics of Signaling during Insulin-stimulated Endocytosis of Its Receptor in Adipocytes (*) , 1995, The Journal of Biological Chemistry.
[38] C. Kahn,et al. The insulin signaling system. , 1994, The Journal of biological chemistry.