APPL1 Potentiates Insulin Sensitivity by Facilitating the Binding of IRS1/2 to the Insulin Receptor

[1]  W. Jia,et al.  Deficiency of APPL1 in mice impairs glucose-stimulated insulin secretion through inhibition of pancreatic beta cell mitochondrial function , 2013, Diabetologia.

[2]  A. Xu,et al.  APPL1 Counteracts Obesity-Induced Vascular Insulin Resistance and Endothelial Dysfunction by Modulating the Endothelial Production of Nitric Oxide and Endothelin-1 in Mice , 2011, Diabetes.

[3]  Y. Kalaidzidis,et al.  Biochemical Characterization of APPL Endosomes: The Role of Annexin A2 in APPL Membrane Recruitment , 2011, Traffic.

[4]  R. Berria,et al.  Increased abundance of the adaptor protein containing pleckstrin homology domain, phosphotyrosine binding domain and leucine zipper motif (APPL1) in patients with obesity and type 2 diabetes: evidence for altered adiponectin signalling , 2011, Diabetologia.

[5]  N. Turner,et al.  The adaptor protein APPL1 increases glycogen accumulation in rat skeletal muscle through activation of the PI3-kinase signalling pathway , 2011, The Journal of endocrinology.

[6]  M. Birnbaum,et al.  Receptor-mediated activation of ceramidase activity initiates the pleiotropic actions of adiponectin , 2011, Nature Medicine.

[7]  F. Liu,et al.  APPL1 mediates adiponectin-stimulated p38 MAPK activation by scaffolding the TAK1-MKK3-p38 MAPK pathway. , 2011, American journal of physiology. Endocrinology and metabolism.

[8]  F. Thong,et al.  An APPL1-AMPK signaling axis mediates beneficial metabolic effects of adiponectin in the heart. , 2010, American journal of physiology. Endocrinology and metabolism.

[9]  J. Testa,et al.  Appl1 is dispensable for Akt signaling in vivo and mouse T‐cell development , 2010, Genesis.

[10]  A. Xu,et al.  Appl1 is essential for the survival of Xenopus pancreas, duodenum, and stomach progenitor cells , 2010, Developmental dynamics : an official publication of the American Association of Anatomists.

[11]  J. McLean,et al.  Identification of phosphorylation sites within the signaling adaptor APPL1 by mass spectrometry. , 2010, Journal of proteome research.

[12]  J. Testa,et al.  Appl1 Is Dispensable for Mouse Development, and Loss of Appl1 Has Growth Factor-selective Effects on Akt Signaling in Murine Embryonic Fibroblasts* , 2009, The Journal of Biological Chemistry.

[13]  Feng Liu,et al.  Yin-Yang Regulation of Adiponectin Signaling by APPL Isoforms in Muscle Cells* , 2009, The Journal of Biological Chemistry.

[14]  J. M. Torres,et al.  Adiponectin Activates AMP-activated Protein Kinase in Muscle Cells via APPL1/LKB1-dependent and Phospholipase C/Ca2+/Ca2+/Calmodulin-dependent Protein Kinase Kinase-dependent Pathways* , 2009, The Journal of Biological Chemistry.

[15]  E. Kraegen,et al.  APPL1 potentiates insulin-mediated inhibition of hepatic glucose production and alleviates diabetes via Akt activation in mice. , 2009, Cell metabolism.

[16]  D. Toomre,et al.  A Phosphoinositide Switch Controls the Maturation and Signaling Properties of APPL Endosomes , 2009, Cell.

[17]  Lily Q. Dong,et al.  APPL1: role in adiponectin signaling and beyond. , 2009, American journal of physiology. Endocrinology and metabolism.

[18]  C. Collinet,et al.  The Endosomal Protein Appl1 Mediates Akt Substrate Specificity and Cell Survival in Vertebrate Development , 2008, Cell.

[19]  M. Czech,et al.  The Interaction of Akt with APPL1 Is Required for Insulin-stimulated Glut4 Translocation* , 2007, Journal of Biological Chemistry.

[20]  G. Shulman,et al.  Obesity-associated improvements in metabolic profile through expansion of adipose tissue. , 2007, The Journal of clinical investigation.

[21]  F. Liu,et al.  Peripheral Disruption of the Grb10 Gene Enhances Insulin Signaling and Sensitivity In Vivo , 2007, Molecular and Cellular Biology.

[22]  D. Carling,et al.  Adiponectin-Induced Endothelial Nitric Oxide Synthase Activation and Nitric Oxide Production Are Mediated by APPL1 in Endothelial Cells , 2007, Diabetes.

[23]  F. Liu,et al.  Adiponectin Sensitizes Insulin Signaling by Reducing p70 S6 Kinase-mediated Serine Phosphorylation of IRS-1* , 2007, Journal of Biological Chemistry.

[24]  Feng Liu,et al.  APPL1 binds to adiponectin receptors and mediates adiponectin signalling and function , 2006, Nature Cell Biology.

[25]  C. Kahn,et al.  Critical nodes in signalling pathways: insights into insulin action , 2006, Nature Reviews Molecular Cell Biology.

[26]  J. Testa,et al.  Human Follicle-Stimulating Hormone (FSH) Receptor Interacts with the Adaptor Protein APPL1 in HEK 293 Cells: Potential Involvement of the PI3K Pathway in FSH Signaling1 , 2004, Biology of reproduction.

[27]  Bianca Habermann,et al.  APPL Proteins Link Rab5 to Nuclear Signal Transduction via an Endosomal Compartment , 2004, Cell.

[28]  Chawnshang Chang,et al.  APPL Suppresses Androgen Receptor Transactivation via Potentiating Akt Activity* , 2003, The Journal of Biological Chemistry.

[29]  Russell L Finley,et al.  Mediation of the DCC Apoptotic Signal by DIP13α* , 2002, The Journal of Biological Chemistry.

[30]  Y. Terauchi,et al.  The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity , 2001, Nature Medicine.

[31]  P. Roey,et al.  HUMAN FOLLICLE STIMULATING HORMONE , 2001 .

[32]  Erica A Golemis,et al.  Identification of a chromosome 3p14.3-21.1 gene, APPL, encoding an adaptor molecule that interacts with the oncoprotein-serine/threonine kinase AKT2 , 1999, Oncogene.

[33]  M. Rose.  Follicle stimulating hormone international standards and reference preparations for the calibration of immunoassays and bioassays. , 1998, Clinica chimica acta; international journal of clinical chemistry.

[34]  L. Dong,et al.  Site-directed mutagenesis and yeast two-hybrid studies of the insulin and insulin-like growth factor-1 receptors: the Src homology-2 domain-containing protein hGrb10 binds to the autophosphorylated tyrosine residues in the kinase domain of the insulin receptor. , 1997, Molecular endocrinology.

[35]  B Wang,et al.  Insulin-induced in situ phosphorylation of the insulin receptor located in the plasma membrane versus endosomes. , 1996, Biochemical and biophysical research communications.

[36]  J. Blenis,et al.  YMXM motifs and signaling by an insulin receptor substrate 1 molecule without tyrosine phosphorylation sites , 1996, Molecular and cellular biology.

[37]  P. Pilch,et al.  Dynamics of Signaling during Insulin-stimulated Endocytosis of Its Receptor in Adipocytes (*) , 1995, The Journal of Biological Chemistry.

[38]  C. Kahn,et al.  The insulin signaling system. , 1994, The Journal of biological chemistry.