Determination of nanoparticle surface coatings and nanoparticle purity using microscale thermogravimetric analysis.

The use of nanoparticles in some applications (i.e., nanomedical, nanofiltration, or nanoelectronic) requires small samples with well-known purities and composition. In addition, when nanoparticles are introduced into complex environments (e.g., biological fluids), the particles may become coated with matter, such as proteins or lipid layers. Many of today's analytical techniques are not able to address small-scale samples of nanoparticles to determine purity and the presence of surface coatings. Through the use of an elevated-temperature quartz crystal microbalance (QCM) method we call microscale thermogravimetric analysis, or μ-TGA, the nanoparticle purity, as well as the presence of any surface coatings of nanomaterials, can be measured. Microscale thermogravimetric analysis is used to determine the presence and amount of surface-bound ligand coverage on gold nanoparticles and confirm the presence of a poly(ethylene glycol) coating on SiO2 nanoparticles. Results are compared to traditional analytical techniques to demonstrate reproducibility and validity of μ-TGA for determining the presence of nanoparticle surface coatings. Carbon nanotube samples are also analyzed and compared to conventional TGA. The results demonstrate μ-TGA is a valid method for quantitative determination of the coatings on nanoparticles, and in some cases, can provide purity and compositional data of the nanoparticles themselves.

[1]  V. M. Mecea,et al.  Loaded vibrating quartz sensors , 1994 .

[2]  D. Baldwin,et al.  Adhesion mechanisms of nanoparticle silver to substrate materials: identification , 2010, Nanotechnology.

[3]  T. Xia,et al.  Understanding biophysicochemical interactions at the nano-bio interface. , 2009, Nature materials.

[4]  Christine S. Grant,et al.  Quartz crystal microbalance in elevated temperature viscous liquids: Temperature effect compensation and lubricant degradation monitoring , 2005 .

[5]  A. Allen,et al.  Challenges for physical characterization of silver nanoparticles under pristine and environmentally relevant conditions. , 2011, Journal of environmental monitoring : JEM.

[6]  B. Yan,et al.  Analytical strategies for characterizing the surface chemistry of nanoparticles , 2010, Analytical and bioanalytical chemistry.

[7]  J. Carlsson,et al.  Development and testing of a high temperature quartz crystal microbalance , 1995 .

[8]  J. Carrillo,et al.  Dynamics of nanoparticle adhesion. , 2012, The Journal of chemical physics.

[9]  A. Hillman,et al.  Dual quartz crystal microbalance oscillator circuit. Minimizing effects due to liquid viscosity, density, and temperature , 1994 .

[10]  Anita Mann,et al.  DNA condensation by poly-L-lysine at the single molecule level: role of DNA concentration and polymer length. , 2008, Journal of controlled release : official journal of the Controlled Release Society.

[11]  Stephanie A. Hooker,et al.  Applications of TGA in quality control of SWCNTs , 2010, Analytical and bioanalytical chemistry.

[12]  Jeffrey T. Roberts,et al.  Thermal oxidation of 6 nm aerosolized silicon nanoparticles: size and surface chemistry changes. , 2007, Langmuir : the ACS journal of surfaces and colloids.

[13]  V. Hackley,et al.  Measuring the Size of Nanoparticles in Aqueous Media Using Batch-Mode Dynamic Light Scattering , 2015 .

[14]  Frank Caruso,et al.  Multilayered Titania, Silica, and Laponite Nanoparticle Coatings on Polystyrene Colloidal Templates and Resulting Inorganic Hollow Spheres , 2001 .

[15]  C. M. Wang,et al.  Statistical sampling of carbon nanotube populations by thermogravimetric analysis , 2013, Analytical and Bioanalytical Chemistry.

[16]  Andrey V Dobrynin,et al.  Adhesion of nanoparticles. , 2010, Langmuir : the ACS journal of surfaces and colloids.

[17]  Elisabeth Mansfield,et al.  Quartz crystal microbalances for microscale thermogravimetric analysis. , 2010, Analytical chemistry.

[18]  R. Sperling,et al.  Surface modification, functionalization and bioconjugation of colloidal inorganic nanoparticles , 2010, Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences.

[19]  András E. Vladár,et al.  Does your SEM really tell the truth? , 2012, Defense + Commercial Sensing.

[20]  T. J. Cho,et al.  Fractionation and characterization of gold nanoparticles in aqueous solution: asymmetric-flow field flow fractionation with MALS, DLS, and UV–Vis detection , 2010, Analytical and bioanalytical chemistry.

[21]  Danielle Cleveland,et al.  Measuring silver nanoparticle dissolution in complex biological and environmental matrices using UV–visible absorbance , 2011, Analytical and bioanalytical chemistry.

[22]  Peter Hauptmann,et al.  Gravimetric and non-gravimetric chemical quartz crystal resonators , 2000 .

[23]  G. Sauerbrey.  Verwendung von Schwingquarzen zur Wägung dünner Schichten und zur Mikrowägung , 1959 .

[24]  J. Lehman,et al.  Quartz-crystal microbalance for in situ monitoring of laser cleaning of carbon nanotubes , 2010 .

[25]  Y. J. V. D. Meulen,et al.  Silicon Oxidation Studies: Analysis of SiO2 Film Growth Data , 1976 .

[26]  Lee L Yu,et al.  Quantification of ligand packing density on gold nanoparticles using ICP-OES , 2012, Analytical and Bioanalytical Chemistry.

[27]  G. Sauerbrey,et al.  Use of quartz vibration for weighing thin films on a microbalance , 1959 .