The case against transfusion‐transmitted non‐ABC hepatitis

The hepatitis C story evolved from prospective studies of post-transfusion hepatitis wherein it was observed in the early 1970s that most cases of transfusion-associated hepatitis were serologically (and later molecularly) unrelated to either the hepatitis A (HAV) or hepatitis B (HBV) viruses.[1] This new clinical entity defined only by ALT elevations and serologic exclusion of HAV and HBV was then designated non-A, non-B hepatitis (NANBH). This awkward nomenclature, rather than hepatitis C, was chosen because, at the time, the presumed agent had not yet been proven to be a transmissible virus, nor were the number of potential NANBH agents known. This article is protected by copyright. All rights reserved.

[1]  K. Rostgaard,et al.  Searching for unknown transfusion‐transmitted hepatitis viruses: a binational cohort study of 1.5 million transfused patients , 2018, Journal of internal medicine.

[2]  M. Houghton,et al.  Hepatitis C Virus and eliminating post-transfusion hepatitis , 2000, Nature Medicine.

[3]  A. E. Yeo,et al.  Transfusion‐associated TT virus infection and its relationship to liver disease , 1999, Hepatology.

[4]  H. Alter.  The cloning and clinical implications of HGV and HGBV-C. , 1996, The New England journal of medicine.

[5]  H. Margolis,et al.  Molecular Cloning and Disease Association of Hepatitis G Virus: A Transfusion-Transmissible Agent , 1996, Science.

[6]  R. Purcell,et al.  Detection of antibody to hepatitis C virus in prospectively followed transfusion recipients with acute and chronic non-A, non-B hepatitis. , 1989, The New England journal of medicine.

[7]  D. Bradley,et al.  Posttransfusion Non-A, Non-B Hepatitis: Physicochemical Properties of Two Distinct Agents , 1983, The Journal of infectious diseases.

[8]  Y. Miyakawa,et al.  Demonstration of two different types of non-A, non-B hepatitis by reinjection and cross-challenge studies in chimpanzees. , 1981, Gastroenterology.

[9]  R. Purcell,et al.  TRANSMISSIBLE AGENT IN NON-A, NON-B HEPATITIS , 1978, The Lancet.

[10]  L. Seeff,et al.  TRANSMISSION OF NON-A, NON-B HEPATITIS FROM MAN TO CHIMPANZEE , 1978, The Lancet.

[11]  R. Purcell,et al.  Multiple Hepatitis Viruses in Multiple Attacks of Acute Viral Hepatitis , 1977 .

[12]  A. Prasad,et al.  Letter: Zinc deficiency in man. , 1974 .

[13]  R. Williams.  Letter: Polymyalgia rheumatica and liver disease. , 1974, Lancet.