Hybrid SPECT/MSCT 3D computational preoperative simulation in breast cancer surgery

Hybrid imaging combining CT and SPECT is becoming a state of the art nuclear medicine technique. Advantages of hybrid imaging are improved quality of the images using CT data for attenuation correction based on true transmission density data in an individual patient, and CT and SPECT fusion images providing accurate localization of the tracer uptake. Accurate localization of increased tracer uptake is very important especially in the diagnostic of tumors. For this purpose a software developed for generating 3D models from standard DICOM images, obtained from CT and SPECT, and then merging these 3D objects, provides us with the exact location of sentinels nodes. This is certainly very helpful for a surgeon performing biopsy. The ability of SPECT/CT to improve diagnostic accuracy, especially specificity, has a great potential in further development of nuclear medicine techniques in evaluation of tumors.

[1]  Zhengyou Zhang,et al.  Microsoft Kinect Sensor and Its Effect , 2012, IEEE Multim..

[2]  P. Sasieni,et al.  Reply to ‘Comment on Cancer incidence in the United Kingdom: projections to the year 2030' , 2013, British Journal of Cancer.

[3]  Mark Hachey,et al.  Breast cancer survivors in the United States , 2009, Cancer.

[4]  Norman Wolmark,et al.  Morbidity results from the NSABP B‐32 trial comparing sentinel lymph node dissection versus axillary dissection , 2010, Journal of surgical oncology.

[5]  T. Julian,et al.  Sentinel-lymph-node resection compared with conventional axillary-lymph-node dissection in clinically node-negative patients with breast cancer: overall survival findings from the NSABP B-32 randomised phase 3 trial. , 2010, The Lancet. Oncology.

[6]  R Peto,et al.  Relevance of breast cancer hormone receptors and other factors to the efficacy of adjuvant tamoxifen: patient-level meta-analysis of randomised trials , 2011, The Lancet.

[7]  A. Jemal,et al.  Global cancer transitions according to the Human Development Index (2008-2030): a population-based study. , 2012, The Lancet. Oncology.

[8]  G Villa,et al.  Sentinel node biopsy compared with complete axillary dissection for staging early breast cancer with clinically negative lymph nodes: results of randomized trial. , 2009, Annals of oncology : official journal of the European Society for Medical Oncology.

[9]  Svein K. Jacobsen,et al.  Improved Resolution and Reduced Clutter in Ultra-Wideband Microwave Imaging Using Cross-Correlated Back Projection: Experimental and Numerical Results , 2011, Int. J. Biomed. Imaging.

[10]  J. Ferlay,et al.  Global estimates of cancer prevalence for 27 sites in the adult population in 2008 , 2013, International journal of cancer.

[11]  Harald Köstler,et al.  Computer-aided evaluation of anatomical accuracy of image fusion between X-ray CT and SPECT , 2008, Comput. Medical Imaging Graph..

[12]  H. Vargas,et al.  Axillary Recurrence after Sentinel Lymph Node Biopsy for Breast Cancer , 2010, The American surgeon.

[13]  Renato A. Valdés Olmos,et al.  The Hybrid SPECT/CT as an Additional Lymphatic Mapping Tool in Patients with Breast Cancer , 2008, World Journal of Surgery.

[14]  B. Smith,et al.  Breast Cancer Survivors in the United States: Geographic Variability and Time Trends, 2005-2015 , 2009 .

[15]  Donald L. Weaver,et al.  Effect of occult metastases on survival in node-negative breast cancer. , 2011, The New England journal of medicine.

[16]  C. Mathers,et al.  Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008 , 2010, International journal of cancer.

[17]  William D. Erwin,et al.  Hybrid Modality Fusion of Planar Scintigrams and CT Topograms to Localize Sentinel Lymph Nodes in Breast Lymphoscintigraphy: Technical Description and Phantom Studies , 2010, International journal of molecular imaging.