Objective: To analyze the knowledge produced in the last decade on hospital costs related to the processing of reusable healthcare products (HP) performed in Sterile Processing Departments (SPD) and processing companies. Method: Integrative literature review, with searches in the following databases: Cumulative Index to Nursing and Allied Health Literature (CINAHL), Medical Literature Analysis and Retrieval System Online (MEDLINE), Latin American and Caribbean Health Sciences Literature (LILACS), Scopus, and Scientific Electronic Library Online (SciELO). The selected articles were published between 2009 and April 2019. The initial search resulted in 782 articles and, after applying the inclusion and exclusion criteria, the final sample consisted of 15 studies, which were analyzed in full. Results: Authors of most studies compared the cost of different technologies employed in the processing of HP to achieve savings, or evaluated the reduction of waste-related expenditures, mainly with the reduction of the size of surgery trays to reduce the processing cost. Conclusion: The processing of HP proved to be a measure that promotes economy when properly selecting the technologies involved in the process and avoiding waste.