Protein-engineered biomaterials: nanoscale mimics of the extracellular matrix.

[1]  G. Bidwell,et al.  A thermally targeted peptide inhibitor of symmetrical dimethylation inhibits cancer-cell proliferation , 2010, Peptides.

[2]  B. Strooper.  Proteases and Proteolysis in Alzheimer Disease: A Multifactorial View on the Disease Process , 2010 .

[3]  G. Ferrari,et al.  Estimating design space available for polyepitopes through consideration of major histocompatibility complex binding motifs , 2010, Biomedical microdevices.

[4]  Amit Jain,et al.  Probing cellular mechanobiology in three-dimensional culture with collagen-agarose matrices. , 2010, Biomaterials.

[5]  S. Heilshorn,et al.  Protein-engineered biomaterials: highly tunable tissue engineering scaffolds. , 2010, Tissue engineering. Part B, Reviews.

[6]  J. A. Kessler,et al.  Emerging peptide nanomedicine to regenerate tissues and organs , 2010, Journal of internal medicine.

[7]  Ji Seok Lee,et al.  Two-component protein-engineered physical hydrogels for cell encapsulation , 2009, Proceedings of the National Academy of Sciences.

[8]  Matthias P. Lutolf,et al.  Designing materials to direct stem-cell fate , 2009, Nature.

[9]  Mikala Egeblad,et al.  Matrix Crosslinking Forces Tumor Progression by Enhancing Integrin Signaling , 2009, Cell.

[10]  S. Heilshorn,et al.  Dynamic, 3D‐Pattern Formation Within Enzyme‐Responsive Hydrogels , 2009 .

[11]  S. Heilshorn,et al.  Enzyme‐Responsive Hydrogels: Dynamic, 3D‐Pattern Formation Within Enzyme‐Responsive Hydrogels (Adv. Mater. 41/2009) , 2009 .

[12]  Sheldon Park,et al.  Protein engineering and design , 2009 .

[13]  S. Heilshorn,et al.  Protein Engineered Biomaterials , 2009 .

[14]  Scott Banta,et al.  A chimeric fusion protein engineered with disparate functionalities-enzymatic activity and self-assembly. , 2009, Journal of molecular biology.

[15]  A. English,et al.  Thin-film enhanced nerve guidance channels for peripheral nerve repair. , 2009, Biomaterials.

[16]  Shy Shoham,et al.  Laser photoablation of guidance microchannels into hydrogels directs cell growth in three dimensions. , 2009, Biophysical journal.

[17]  Dany J. Munoz-Pinto,et al.  Uncoupled investigation of scaffold modulus and mesh size on smooth muscle cell behavior. , 2009, Journal of biomedical materials research. Part A.

[18]  Chao-Min Cheng,et al.  Composite polymer systems with control of local substrate elasticity and their effect on cytoskeletal and morphological characteristics of adherent cells. , 2009, Biomaterials.

[19]  Kristi S. Anseth,et al.  Photodegradable Hydrogels for Dynamic Tuning of Physical and Chemical Properties , 2009, Science.

[20]  Sarah C. Heilshorn,et al.  Design and Adsorption of Modular Engineered Proteins to Prepare Customized, Neuron-Compatible Coatings , 2009, Front. Neuroeng..

[21]  David J. Mooney,et al.  Infection-Mimicking Materials to Program Dendritic Cells In Situ , 2008, Nature materials.

[22]  Adam J Engler,et al.  Embryonic cardiomyocytes beat best on a matrix with heart-like elasticity: scar-like rigidity inhibits beating , 2008, Journal of Cell Science.

[23]  Albert J. Keung,et al.  Substrate modulus directs neural stem cell behavior. , 2008, Biophysical journal.

[24]  Christopher S. Chen.  Mechanotransduction – a field pulling together? , 2008, Journal of Cell Science.

[25]  Scott Calabrese Barton,et al.  Bioelectrocatalytic hydrogels from electron-conducting metallopolypeptides coassembled with bifunctional enzymatic building blocks , 2008, Proceedings of the National Academy of Sciences.

[26]  Ashutosh Chilkoti,et al.  Peptide-based Biopolymers in Biomedicine and Biotechnology. , 2008, Materials science & engineering. R, Reports : a review journal.

[27]  Samuel K Sia,et al.  In situ collagen assembly for integrating microfabricated three-dimensional cell-seeded matrices. , 2008, Nature materials.

[28]  D. Schaffer,et al.  Engineering biomaterials for synthetic neural stem cell microenvironments. , 2008, Chemical reviews.

[29]  Robert Langer,et al.  Incorporation of a matrix metalloproteinase-sensitive substrate into self-assembling peptides - a model for biofunctional scaffolds. , 2008, Biomaterials.

[30]  Martin L Yarmush,et al.  Three-dimensional primary hepatocyte culture in synthetic self-assembling peptide hydrogel. , 2008, Tissue engineering. Part A.

[31]  K. Kiick.  Biosynthetic Methods for the Production of Advanced Protein-Based Materials , 2007 .

[32]  Jennifer T. Blundo,et al.  In vivo imaging and evaluation of different biomatrices for improvement of stem cell survival , 2007, Journal of tissue engineering and regenerative medicine.

[33]  Lila R Collins,et al.  Cardiomyocytes derived from human embryonic stem cells in pro-survival factors enhance function of infarcted rat hearts , 2007, Nature Biotechnology.

[34]  Christopher Cannizzaro,et al.  Nanofabrication and microfabrication of functional materials for tissue engineering. , 2007, Tissue engineering.

[35]  Krishanu Saha,et al.  Designing synthetic materials to control stem cell phenotype. , 2007, Current opinion in chemical biology.

[36]  G. Ravichandran,et al.  Lithographic patterning of photoreactive cell-adhesive proteins. , 2007, Journal of the American Chemical Society.

[37]  L. Setton,et al.  Rapid cross-linking of elastin-like polypeptides with (hydroxymethyl)phosphines in aqueous solution. , 2007, Biomacromolecules.

[38]  Anna Rising,et al.  Macroscopic fibers self-assembled from recombinant miniature spider silk proteins. , 2007, Biomacromolecules.

[39]  Krishanu Saha,et al.  Biomimetic interfacial interpenetrating polymer networks control neural stem cell behavior. , 2007, Journal of biomedical materials research. Part A.

[40]  E. Furst,et al.  Growth factor mediated assembly of cell receptor-responsive hydrogels. , 2007, Journal of the American Chemical Society.

[41]  J. Hartgerink,et al.  Self-assembled heterotrimeric collagen triple helices directed through electrostatic interactions. , 2007, Journal of the American Chemical Society.

[42]  Luís Pimenta,et al.  Nubac Disc Arthroplasty: Preclinical Studies and Preliminary Safety and Efficacy Evaluations , 2007, SAS Journal.

[43]  G. Vunjak‐Novakovic,et al.  Stem cell-based tissue engineering with silk biomaterials. , 2006, Biomaterials.

[44]  Derek N Woolfson,et al.  Peptide-based fibrous biomaterials: Some things old, new and borrowed. , 2006, Current opinion in chemical biology.

[45]  Gianguido C. Cianci,et al.  A genetic toolbox for creating reversible Ca2+-sensitive materials. , 2006, Journal of the American Chemical Society.

[46]  Jennifer H Elisseeff,et al.  Collagen mimetic peptide-conjugated photopolymerizable PEG hydrogel. , 2006, Biomaterials.

[47]  S. Sen,et al.  Matrix Elasticity Directs Stem Cell Lineage Specification , 2006, Cell.

[48]  D. Lauffenburger,et al.  Migration of tumor cells in 3D matrices is governed by matrix stiffness along with cell-matrix adhesion and proteolysis. , 2006, Proceedings of the National Academy of Sciences of the United States of America.

[49]  Ahmad Y. Sheikh,et al.  Collagen Matrices Enhance Survival of Transplanted Cardiomyoblasts and Contribute to Functional Improvement of Ischemic Rat Hearts , 2006, Circulation.

[50]  David L Kaplan,et al.  Novel nanocomposites from spider silk-silica fusion (chimeric) proteins. , 2006, Proceedings of the National Academy of Sciences of the United States of America.

[51]  L. Griffith,et al.  Capturing complex 3D tissue physiology in vitro , 2006, Nature Reviews Molecular Cell Biology.

[52]  Kechun Zhang,et al.  Tuning the erosion rate of artificial protein hydrogels through control of network topology , 2006, Nature materials.

[53]  K. Healy,et al.  The effect of ligand type and density on osteoblast adhesion, proliferation, and matrix mineralization. , 2005, Journal of biomedical materials research. Part A.

[54]  P. Janmey,et al.  Tissue Cells Feel and Respond to the Stiffness of Their Substrate , 2005, Science.

[55]  Ashutosh Chilkoti,et al.  Synthesis and in vitro evaluation of enzymatically cross-linked elastin-like polypeptide gels for cartilaginous tissue repair. , 2005, Tissue engineering.

[56]  T. Vuocolo,et al.  Synthesis and properties of crosslinked recombinant pro-resilin , 2005, Nature.

[57]  C. Cho,et al.  Construction of a Novel Extracellular Matrix using a New Genetically Engineered Epidermal Growth Factor Fused to IgG-Fc , 2005, Biotechnology Letters.

[58]  W. P. Russ,et al.  Natural-like function in artificial WW domains , 2005, Nature.

[59]  David A Tirrell,et al.  Protein engineering approaches to biomaterials design. , 2005, Current opinion in biotechnology.

[60]  Paul Matsudaira,et al.  Computational model for cell migration in three-dimensional matrices. , 2005, Biophysical journal.

[61]  J. Hubbell,et al.  Molecularly engineered PEG hydrogels: a novel model system for proteolytically mediated cell migration. , 2005, Biophysical journal.

[62]  Robert Langer,et al.  Biomaterial microarrays: rapid, microscale screening of polymer-cell interaction. , 2005, Biomaterials.

[63]  Natalia Juncosa-Melvin,et al.  Effects of cell-to-collagen ratio in mesenchymal stem cell-seeded implants on tendon repair biomechanics and histology. , 2005, Tissue engineering.

[64]  David A Tirrell,et al.  Cell-binding domain context affects cell behavior on engineered proteins. , 2005, Biomacromolecules.

[65]  J. Rodríguez‐Cabello,et al.  Design and bioproduction of a recombinant multi(bio)functional elastin-like protein polymer containing cell adhesion sequences for tissue engineering purposes , 2004, Journal of materials science. Materials in medicine.

[66]  Ying Luo,et al.  A photolabile hydrogel for guided three-dimensional cell growth and migration , 2004, Nature materials.

[67]  D Seliktar,et al.  MMP-2 sensitive, VEGF-bearing bioactive hydrogels for promotion of vascular healing. , 2004, Journal of biomedical materials research. Part A.

[68]  David A Tirrell,et al.  Comparative cell response to artificial extracellular matrix proteins containing the RGD and CS5 cell-binding domains. , 2004, Biomacromolecules.

[69]  David A Tirrell,et al.  Physical properties of artificial extracellular matrix protein films prepared by isocyanate crosslinking. , 2004, Biomaterials.

[70]  Krista L. Niece,et al.  Selective Differentiation of Neural Progenitor Cells by High-Epitope Density Nanofibers , 2004, Science.

[71]  Chikako Tanaka,et al.  Production and characterization of a silk-like hybrid protein, based on the polyalanine region of Samia cynthia ricini silk fibroin and a cell adhesive region derived from fibronectin. , 2004, Biomaterials.

[72]  David A Tirrell,et al.  Endothelial cell adhesion to the fibronectin CS5 domain in artificial extracellular matrix proteins. , 2003, Biomaterials.

[73]  David A. Tirrell,et al.  Engineering of the Extracellular Matrix: Working toward Neural Stem Cell Programming and Neurorestoration— Concept and Progress Report , 2003 .

[74]  Ashutosh Chilkoti,et al.  Swelling and mechanical behaviors of chemically cross-linked hydrogels of elastin-like polypeptides. , 2003, Biomacromolecules.

[75]  Daniel A. Hammer,et al.  Endothelial Cell Traction Forces on RGD-Derivatized Polyacrylamide Substrata † , 2003 .

[76]  David L Kaplan,et al.  Silk-based biomaterials. , 2003, Biomaterials.

[77]  Wonmuk Hwang,et al.  Design of nanostructured biological materials through self-assembly of peptides and proteins. , 2002, Current opinion in chemical biology.

[78]  T. Akaike,et al.  Immobilized E-cadherin model can enhance cell attachment and differentiation of primary hepatocytes but not proliferation , 2002, Biotechnology Letters.

[79]  H. Ghandehari,et al.  Genetically engineered silk-elastinlike protein polymers for controlled drug delivery. , 2002, Advanced drug delivery reviews.

[80]  Nasreen S Jessani,et al.  Enzyme activity profiles of the secreted and membrane proteome that depict cancer cell invasiveness , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[81]  Cheryl Miller,et al.  Synergistic effects of physical and chemical guidance cues on neurite alignment and outgrowth on biodegradable polymer substrates. , 2002, Tissue engineering.

[82]  Alyssa Panitch,et al.  Biologically engineered protein-graft-poly(ethylene glycol) hydrogels: a cell adhesive and plasmin-degradable biosynthetic material for tissue repair. , 2002, Biomacromolecules.

[83]  David J Mooney,et al.  Alginate type and RGD density control myoblast phenotype. , 2002, Journal of biomedical materials research.

[84]  J. West,et al.  Cell migration through defined, synthetic extracellular matrix analogues , 2002, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[85]  Ashutosh Chilkoti,et al.  Genetically encoded synthesis of protein-based polymers with precisely specified molecular weight and sequence by recursive directional ligation: examples from the elastin-like polypeptide system. , 2002, Biomacromolecules.

[86]  Kenneth M. Yamada,et al.  Taking Cell-Matrix Adhesions to the Third Dimension , 2001, Science.

[87]  D. Tirrell,et al.  Biosynthesis of a highly stable coiled-coil protein containing hexafluoroleucine in an engineered bacterial host. , 2001, Journal of the American Chemical Society.

[88]  D. Mooney,et al.  Polymeric system for dual growth factor delivery , 2001, Nature Biotechnology.

[89]  L G Griffith,et al.  Effect of pore size and void fraction on cellular adhesion, proliferation, and matrix deposition. , 2001, Tissue engineering.

[90]  N. Cox,et al.  Calpains play a role in insulin secretion and action. , 2001, Diabetes.

[91]  K Walsh,et al.  Cardiomyocyte grafting for cardiac repair: graft cell death and anti-death strategies. , 2001, Journal of molecular and cellular cardiology.

[92]  S J Bryant,et al.  The effects of scaffold thickness on tissue engineered cartilage in photocrosslinked poly(ethylene oxide) hydrogels. , 2001, Biomaterials.

[93]  J. Elisseeff,et al.  Photoencapsulation of chondrocytes in poly(ethylene oxide)-based semi-interpenetrating networks. , 2000, Journal of biomedical materials research.

[94]  C. Craik,et al.  Rapid and general profiling of protease specificity by using combinatorial fluorogenic substrate libraries. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[95]  D. Tirrell,et al.  Engineering the extracellular matrix: a novel approach to polymeric biomaterials. I. Control of the physical properties of artificial protein matrices designed to support adhesion of vascular endothelial cells. , 2000, Biomacromolecules.

[96]  Ashutosh Chilkoti,et al.  Purification of recombinant proteins by fusion with thermally-responsive polypeptides , 1999, Nature Biotechnology.

[97]  N. Peppas,et al.  Poly(ethylene glycol)-containing hydrogels in drug delivery. , 1999, Journal of controlled release : official journal of the Controlled Release Society.

[98]  T. Yamaoka,et al.  Design and Biosynthesis of Elastin-like Artificial Extracellular Matrix Proteins Containing Periodically Spaced Fibronectin CS5 Domains , 1999 .

[99]  D J Mooney,et al.  Development of biocompatible synthetic extracellular matrices for tissue engineering. , 1998, Trends in biotechnology.

[100]  Anderson,et al.  Host response to tissue engineered devices. , 1998, Advanced drug delivery reviews.

[101]  D. Wirtz,et al.  Reversible hydrogels from self-assembling artificial proteins. , 1998, Science.

[102]  S. Britland,et al.  Contact guidance of CNS neurites on grooved quartz: influence of groove dimensions, neuronal age and cell type. , 1997, Journal of cell science.

[103]  Sean P. Palecek,et al.  Erratum: Integrin–ligand binding properties govern cell migration speed through cell–substratum adhesiveness , 1997, Nature.

[104]  N. Seeds,et al.  Neuronal extracellular proteases facilitate cell migration, axonal growth, and pathfinding , 1997, Cell and Tissue Research.

[105]  W. Risau,et al.  Mechanisms of angiogenesis , 1997, Nature.

[106]  D. Ingber,et al.  Prevascularization of porous biodegradable polymers , 1993, Biotechnology and bioengineering.

[107]  P Connolly,et al.  Growth cone guidance and neuron morphology on micropatterned laminin surfaces. , 1993, Journal of cell science.

[108]  R Langer,et al.  Switching from differentiation to growth in hepatocytes: Control by extracellular matrix , 1992, Journal of cellular physiology.

[109]  D. Gowda,et al.  Cell adhesion and growth on synthetic elastomeric matrices containing Arg-Gly-Asp-Ser-3. , 1992, Journal of biomedical materials research.

[110]  John P. Overington,et al.  Protein engineering and design. , 1989, Philosophical transactions of the Royal Society of London. Series B, Biological sciences.

[111]  M. Presta,et al.  Purification of a factor from human placenta that stimulates capillary endothelial cell protease production, DNA synthesis, and migration. , 1986, Proceedings of the National Academy of Sciences of the United States of America.

[112]  J. McPherson,et al.  The human immune response to reconstituted bovine collagen. , 1986, Journal of immunology.

[113]  M. Bissell,et al.  Interaction of mouse mammary epithelial cells with collagen substrata: regulation of casein gene expression and secretion. , 1985, Proceedings of the National Academy of Sciences of the United States of America.

[114]  Sarah C. Heilshorn,et al.  Independent tuning of multiple biomaterial properties using protein engineering , 2009 .

[115]  Elliot L Chaikof,et al.  Elastin-mimetic protein polymers capable of physical and chemical crosslinking. , 2009, Biomaterials.

[116]  A. Chilkoti,et al.  Ultra‐High Expression of a Thermally Responsive Recombinant Fusion Protein in E. coli , 2006, Biotechnology progress.

[117]  C. V. van Blitterswijk,et al.  The effect of PEGT/PBT scaffold architecture on the composition of tissue engineered cartilage. , 2005, Biomaterials.

[118]  T. Holmes,et al.  Novel peptide-based biomaterial scaffolds for tissue engineering. , 2002, Trends in biotechnology.

[119]  Jeffrey A. Hubbell,et al.  Polymeric biomaterials with degradation sites for proteases involved in cell migration , 1999 .

[120]  N. Peppas,et al.  Hydrogels as mucoadhesive and bioadhesive materials: a review. , 1996, Biomaterials.

[121]  A. J. Clifford,et al.  BIOCHIMICA ET BIOPHYSICA ACTA , 2022 .