Nowadays, several studies on 3D medical image registration are being investigated. The main purpose of these studies is to integrate complimentary information provided by different modalities. This paper describes a newly developed registration method of ultrasound echography to 3D medical image. The registration process consists of two stages. In the first stage, a registration process of the ultrasound echography to the pre- operative 3D images is performed using a position sensor. This is a rigid transformation, which can't provide a perfect match because the intra-operative organ is deformed or moved. The second step is a local matching process, where the current position of the ultrasound echography is approximated with a search-based surface matching algorithm. We used the 3D chamfer matching for this approximation. In this method, a goodness-of- match function, i.e., generalized distance, that rates the geometrical transformation is computed and minimized. In a preliminary experiment, the search-based matching process was examined. The algorithm and its accuracy were evaluated with an artificial transformed set of coordinates given as the initial guess. We also performed a clinical application and results confirmed the suitability of this method to clinical use.
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