Measuring signal fluctuations in gait rhythm time series of patients with Parkinson's disease using entropy parameters

Abstract Gait rhythm disturbances due to abnormal strides indicate the degenerative mobility regulation of motor neurons affected by Parkinson's disease (PD). The aim of this work is to compute the approximate entropy (ApEn), normalized symbolic entropy (NSE), and signal turns count (STC) parameters for the measurements of stride fluctuations in PD. Generalized linear regression analysis (GLRA) and support vector machine (SVM) techniques were employed to implement nonlinear gait pattern classifications. The classification performance was evaluated in terms of overall accuracy, sensitivity, specificity, precision, Matthews correlation coefficient (MCC), and area under the receiver operating characteristic (ROC) curve. Our experimental results indicated that the ApEn, NSE, and STC parameters computed from the stride series of PD patients were all significantly larger (Wilcoxon rank-sum test: p

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