Long term follow‐up of women with ductal carcinoma in situ treated with breast‐conserving surgery

Although in recent years there has been a dramatic increase in both the incidence of ductal carcinoma in situ (DCIS) and breast‐conserving therapy for patients who have this disease, the optimal treatment for these patients remains controversial. Most data regarding outcomes have come from small, retrospective studies, with little data published from prospective, randomized studies. This study investigates the effects of age, postoperative breast irradiation, and other factors on local relapse free survival after breast‐conserving surgery for women with DCIS in a large, single‐institution series.

[1]  G. Noël,et al.  [Lumpectomy and radiation therapy for the treatment of intraductal breast cancer: findings from national surgical adjuvant breast and bowel project B-17]. , 1999, Cancer radiotherapie : journal de la Societe francaise de radiotherapie oncologique.

[2]  S. Martino,et al.  The influence of margin width on local control of ductal carcinoma in situ of the breast. , 1999, The New England journal of medicine.

[3]  Taylor Murray,et al.  Cancer statistics, 1999 , 1999, CA: a cancer journal for clinicians.

[4]  P. Borgen,et al.  Women 35 years of age or younger have higher locoregional relapse rates after undergoing breast conservation therapy. , 1998, Journal of the American College of Surgeons.

[5]  R. J. Rosser Consensus conference on the classification of ductal carcinoma in Situ , 1998, Cancer.

[6]  E. Perez,et al.  Comparison of single-dose oral granisetron versus intravenous ondansetron in the prevention of nausea and vomiting induced by moderately emetogenic chemotherapy: a multicenter, double-blind, randomized parallel study. , 1998, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[7]  P. Perrotta,et al.  Conservatively Treated Breast Cancer: Outcome by Histologic Subtype , 1997 .

[8]  D. Schultz,et al.  Mammographically detected, clinically occult ductal carcinoma in situ treated with breast-conserving surgery and definitive breast irradiation. , 1996, The cancer journal from Scientific American.

[9]  H. Bear,et al.  Long-term results of breast conservation therapy for breast cancer. , 1996, Annals of surgery.

[10]  M. Silverstein,et al.  A prognostic index for ductal carcinoma in situ of the breast , 1996, Cancer.

[11]  K. Kerlikowske,et al.  Incidence of and treatment for ductal carcinoma in situ of the breast. , 1996, JAMA.

[12]  D. Schultz,et al.  Fifteen-year results of breast-conserving surgery and definitive breast irradiation for the treatment of ductal carcinoma in situ of the breast. , 1996, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[13]  B. Fowble The Role of Radiotherapy in the Treatment of Ductal Carcinoma In Situ—The Challenge of the 1990s , 1996 .

[14]  J. Warneke,et al.  Influence of local treatment on the recurrence rate of ductal carcinoma in situ. , 1995, Journal of the American College of Surgeons.

[15]  Anthony J. Guidi,et al.  Local recurrence after conservative surgery and radiation therapy for ductal carcinoma in situ: Possible importance of family history. , 1995, The cancer journal from Scientific American.

[16]  P Okunieff,et al.  Ten-year results of a comparison of conservation with mastectomy in the treatment of stage I and II breast cancer. , 1995, The New England journal of medicine.

[17]  J. Costantino,et al.  Pathologic findings from the national surgical adjuvant breast project (NSABP) protocol B‐17: Intraductal carcinoma (ductal carcinoma in situ) , 2006 .

[18]  F. Vicini,et al.  Outcome and prognostic factors for local recurrence in mammographically detected ductal carcinoma in situ of the breast treated with conservative surgery and radiation therapy. , 1995, International journal of radiation oncology, biology, physics.

[19]  A. Marzoni,et al.  Ductal carcinoma in situ of the breast: results of treatment by conservative surgery and definitive irradiation. , 1994, International journal of radiation oncology, biology, physics.

[20]  A. Luini,et al.  Radiotherapy after breast-preserving surgery in women with localized cancer of the breast. , 1993, The New England journal of medicine.

[21]  B Fisher,et al.  Lumpectomy compared with lumpectomy and radiation therapy for the treatment of intraductal breast cancer. , 1993, The New England journal of medicine.

[22]  B. Cady Duct Carcinoma In Situ , 1993 .

[23]  A. Patchefsky,et al.  Subclinical ductal carcinoma in situ of the breast: Treatment by local excision and surveillance alone , 1992, Cancer.

[24]  M. Silverstein,et al.  Duct carcinoma in situ: 227 cases without microinvasion. , 1992, European journal of cancer.

[25]  E van der Schueren,et al.  Randomized clinical trial to assess the value of breast-conserving therapy in stage I and II breast cancer, EORTC 10801 trial. , 1992, Journal of the National Cancer Institute. Monographs.

[26]  H. Mouridsen,et al.  Danish randomized trial comparing breast conservation therapy with mastectomy: six years of life-table analysis. Danish Breast Cancer Cooperative Group. , 1992, Journal of the National Cancer Institute. Monographs.

[27]  D. Schultz,et al.  Ten‐year results of breast‐conserving surgery and definitive irradiation for intraductal carcinoma (ductal carcinoma in situ) of the breast , 1991, Cancer.

[28]  M. Silverstein,et al.  Evaluation of Treatment Options for Ductal Carcinoma In Situ of the Breast-Reply , 1991 .

[29]  A. Ringberg,et al.  Breast carcinoma in situ in 167 women--incidence, mode of presentation, therapy and follow-up. , 1991, European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology.

[30]  J. Gazet,et al.  Breast conserving surgery in the management of in situ breast carcinoma. , 1991, European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology.

[31]  Takuma Nemoto,et al.  Factors affecting recurrence in lumpectomy without irradiation for breast cancer , 1991, Cancer.

[32]  M. Silverstein,et al.  Radiation therapy for intraductal carcinoma. Is it an equal alternative? , 1991, Archives of surgery.

[33]  M. Silverstein,et al.  Axillary lymphadenectomy for intraductal carcinoma of the breast. , 1991, Surgery, gynecology & obstetrics.

[34]  D. Page Intraductal breast carcinoma. Review of a multicenter series of 350 cases. , 1991, Tumori.

[35]  S. Schnitt,et al.  Results of treating ductal carcinoma In situ of the breast with conservative surgery and radiation therapy , 1991, Cancer.

[36]  P. Dl Intraductal breast carcinoma. Review of a multicenter series of 350 cases. , 1990 .

[37]  S. Ciatto,et al.  Intraductal Breast Carcinoma. Review of a Multicenter Series of 350 Cases , 1990, Tumori.

[38]  M. Lagios Duct carcinoma in situ. Pathology and treatment. , 1990, The Surgical clinics of North America.

[39]  M. Silverstein,et al.  Intraductal carcinoma of the breast (208 cases): Clinical factors influencing treatment choice , 1990, Cancer.

[40]  B. Gusterson,et al.  Duct carcinoma in situ: predictors of local recurrence and progression in patients treated by surgery alone. , 1990, British Journal of Cancer.

[41]  F. Ames,et al.  The role of limited surgery with irradiation in primary treatment of ductal in situ breast cancer. , 1990, International journal of radiation oncology, biology, physics.

[42]  A. Luini,et al.  Breast conservation is the treatment of choice in small breast cancer: long-term results of a randomized trial. , 1990, European journal of cancer.

[43]  F. Ames,et al.  Predicting the rate and extent of locoregional failure after breast conservation therapy for early breast cancer , 1989, Cancer.

[44]  A. Lees,et al.  Natural history of in situ breast cancer in a defined population. , 1989, Annals of surgery.

[45]  O. Gröntoft,et al.  Follow‐up of two treatment modalities for ductal cancer in situ of the breast , 1989, The British journal of surgery.

[46]  B. Fowble Intraductal noninvasive breast cancer: a comparison of three local treatments. , 1989, Oncology.

[47]  B Fisher,et al.  Eight-year results of a randomized clinical trial comparing total mastectomy and lumpectomy with or without irradiation in the treatment of breast cancer. , 1989, The New England journal of medicine.

[48]  W. Wood,et al.  Treatment of intraductal carcinoma with limited surgery: long-term follow-up. , 1989, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[49]  R. Arriagada,et al.  Ten-year results of a randomized trial comparing a conservative treatment to mastectomy in early breast cancer. , 1989, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.

[50]  M. Lagios,et al.  Mammographically detected duct carcinoma in situ. Frequency of local recurrence following tylectomy and prognostic effect of nuclear grade on local recurrence , 1989, Cancer.

[51]  M P Osborne,et al.  Breast carcinoma in situ. , 1989, Archives of surgery.

[52]  N. Dubrawsky Cancer statistics , 1989, CA: a cancer journal for clinicians.

[53]  C. Bressac,et al.  Mammary recurrences in women younger than forty. , 1988, International journal of radiation oncology, biology, physics.

[54]  W. P. Greening,et al.  Quadrantic excision and axillary node dissection without radiation therapy: the long-term results of a selective policy in the treatment of stage I breast cancer. , 1988, European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology.

[55]  S. Schnitt,et al.  The effect of young age on tumor recurrence in the treated breast after conservative surgery and radiotherapy. , 1988, International journal of radiation oncology, biology, physics.

[56]  M. Silverstein,et al.  Axillary lymph node dissection for intraductal breast carcinoma‐is it indicated? , 1987, Cancer.

[57]  J. Kurtz,et al.  Conservation treatment of early breast cancer: long term results and complications. , 1987, International journal of radiation oncology, biology, physics.

[58]  S. Paik,et al.  Pathologic findings from the National Surgical Adjuvant Breast Project (protocol 6). I. Intraductal carcinoma (DCIS) , 1986 .

[59]  P. Vielh,et al.  Local control and survival of breast cancer treated by limited surgery followed by irradiation. , 1986, International journal of radiation oncology, biology, physics.

[60]  S. Paik,et al.  Pathologic findings from the national surgical adjuvant breast project (protocol 6) I. Intraductal carcinoma (DCIS) , 1986, Cancer.

[61]  W. Fletcher,et al.  Breast carcinoma in situ. A retrospective review of 112 cases with a minimum 10 year follow-up. , 1985, American journal of surgery.

[62]  R. Wilson,et al.  Intraductal carcinoma of the breast. , 1984, Surgery, gynecology & obstetrics.

[63]  M. Lagios,et al.  Duct carcinoma in situ. Relationship of extent of noninvasive disease to the frequency of occult invasion, multicentricity, lymph node metastases, and short-term treatment failures. , 1982, Cancer.

[64]  G. Murphy,et al.  Noninvasive Breast Carcinoma: Results of a National Survey by the American College of Surgeons , 1980, Annals of surgery.

[65]  S. Hajdu,et al.  Intraductal carcinoma of the breast (1960–1969) , 1971, Cancer.

[66]  J. Farrow The James Ewing lecture current concepts in the detection and treatment of the earliest of the early breast cancers , 1970 .

[67]  A. Stout Intraductal carcinoma of breast. , 1947, Missouri medicine.