Fetal sheep supports the development of hematopoietic cells in vivo from human iPSCs.

[1]  B. Göttgens,et al.  From haematopoietic stem cells to complex differentiation landscapes , 2018, Nature.

[2]  Y. Sonoda,et al.  CD34-negative hematopoietic stem cells show distinct expression profiles of homing molecules that limit engraftment in mice and sheep , 2017, International Journal of Hematology.

[3]  A. Engelman,et al.  Haematopoietic stem and progenitor cells from human pluripotent stem cells , 2017, Nature.

[4]  G. Keller,et al.  A view of human haematopoietic development from the Petri dish , 2016, Nature Reviews Molecular Cell Biology.

[5]  G. Daley,et al.  Progress towards generation of human haematopoietic stem cells , 2016, Nature Cell Biology.

[6]  K. Akashi,et al.  Enhanced Reconstitution of Human Erythropoiesis and Thrombopoiesis in an Immunodeficient Mouse Model with KitWv Mutations , 2016, Stem cell reports.

[7]  K. Moore,et al.  Making a Hematopoietic Stem Cell. , 2016, Trends in cell biology.

[8]  H. Okano,et al.  Grafted Human iPS Cell-Derived Oligodendrocyte Precursor Cells Contribute to Robust Remyelination of Demyelinated Axons after Spinal Cord Injury , 2015, Stem cell reports.

[9]  B. Hadland,et al.  Endothelium and NOTCH specify and amplify aorta-gonad-mesonephros-derived hematopoietic stem cells. , 2015, The Journal of clinical investigation.

[10]  G. Daley,et al.  De novo generation of HSCs from somatic and pluripotent stem cell sources. , 2015, Blood.

[11]  Y. Hanazono,et al.  A Long-term Follow-up Study on the Engraftment of Human Hematopoietic Stem Cells in Sheep , 2014, Experimental Animals.

[12]  I. Slukvin Hematopoietic specification from human pluripotent stem cells: current advances and challenges toward de novo generation of hematopoietic stem cells. , 2013, Blood.

[13]  M. Berg,et al.  Bringing natural killer cells to the clinic: ex vivo manipulation. , 2013, Hematology. American Society of Hematology. Education Program.

[14]  D. Sugiyama,et al.  Mesodermal and Hematopoietic Differentiation from ES and iPS Cells , 2013, Stem Cell Reviews and Reports.

[15]  G. Keller,et al.  Defining the path to hematopoietic stem cells , 2013, Nature Biotechnology.

[16]  Gordon Keller,et al.  T lymphocyte potential marks the emergence of definitive hematopoietic progenitors in human pluripotent stem cell differentiation cultures. , 2012, Cell reports.

[17]  Yong-Guang Yang,et al.  Full reconstitution of human platelets in humanized mice after macrophage depletion. , 2012, Blood.

[18]  Y. Hanazono,et al.  Maternal administration of busulfan before in utero transplantation of human hematopoietic stem cells enhances engraftments in sheep. , 2012, Experimental hematology.

[19]  Yong-Guang Yang,et al.  Macrophages prevent human red blood cell reconstitution in immunodeficient mice. , 2011, Blood.

[20]  R. Flavell,et al.  Transgenic expression of human signal regulatory protein alpha in Rag2−/−γc−/− mice improves engraftment of human hematopoietic cells in humanized mice , 2011, Proceedings of the National Academy of Sciences.

[21]  Yasuko Matsumura,et al.  A more efficient method to generate integration-free human iPS cells , 2011, Nature Methods.

[22]  Y. Hanazono,et al.  Intravascular route is not superior to an intraperitoneal route for in utero transplantation of human hematopoietic stem cells and engraftment in sheep. , 2010, Transplantation.

[23]  G. Daley,et al.  Hematopoietic Development from Human Induced Pluripotent Stem Cells , 2009, Annals of the New York Academy of Sciences.

[24]  Y. Hanazono,et al.  Improved efficacy and safety of in utero cell transplantation in sheep using an ultrasound-guided method. , 2009, Cloning and stem cells.

[25]  Michael S. Becker,et al.  Fate tracing reveals the endothelial origin of hematopoietic stem cells. , 2008, Cell stem cell.

[26]  M. Stojkovic,et al.  Efficient hematopoietic differentiation of human embryonic stem cells on stromal cells derived from hematopoietic niches. , 2008, Cell stem cell.

[27]  L. Zon,et al.  Hematopoiesis: An Evolving Paradigm for Stem Cell Biology , 2008, Cell.

[28]  Ulrich H. von Andrian,et al.  Stem Cell Trafficking in Tissue Development, Growth, and Disease , 2008, Cell.

[29]  T. Ichisaka,et al.  Induction of Pluripotent Stem Cells from Adult Human Fibroblasts by Defined Factors , 2007, Cell.

[30]  S. Orkin,et al.  The journey of developing hematopoietic stem cells , 2006, Development.

[31]  A. Iwama,et al.  Endomucin, a CD34-like sialomucin, marks hematopoietic stem cells throughout development , 2005, The Journal of experimental medicine.

[32]  K. Ozawa,et al.  Hematopoietic Microchimerism in Sheep After In Utero Transplantation of Cultured Cynomolgus Embryonic Stem Cells , 2005, Transplantation.

[33]  I. Weissman,et al.  Circulation and Chemotaxis of Fetal Hematopoietic Stem Cells , 2004, PLoS biology.

[34]  S. Ogawa,et al.  Notch1 but not Notch2 is essential for generating hematopoietic stem cells from endothelial cells. , 2003, Immunity.

[35]  S. Orkin,et al.  Expression of CD41 marks the initiation of definitive hematopoiesis in the mouse embryo. , 2003, Blood.

[36]  I. Bernstein,et al.  Delta-1 enhances marrow and thymus repopulating ability of human CD34(+)CD38(-) cord blood cells. , 2002, The Journal of clinical investigation.

[37]  E. Oberlin,et al.  Blood-forming potential of vascular endothelium in the human embryo. , 2002, Development.

[38]  A. Flake,et al.  Complete allogeneic hematopoietic chimerism achieved by a combined strategy of in utero hematopoietic stem cell transplantation and postnatal donor lymphocyte infusion. , 2002, Blood.

[39]  Elaine Dzierzak,et al.  Runx1 expression marks long-term repopulating hematopoietic stem cells in the midgestation mouse embryo. , 2002, Immunity.

[40]  James A. Thomson,et al.  Hematopoietic colony-forming cells derived from human embryonic stem cells , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[41]  J. Yélamos,et al.  Human anti-porcine gammadelta T-cell xenoreactivity is inhibited by human FasL expression on porcine endothelial cells. , 2001, Transplantation.

[42]  J. Seebach,et al.  Human NK cells lyse porcine endothelial cells via the perforin/granzyme B pathway. , 2001, Transplantation proceedings.

[43]  G. Almeida-Porada,et al.  Transplantation of hematopoietic stem cells in utero , 1997, Stem cells.

[44]  T. Honjo,et al.  Generation of lymphohematopoietic cells from embryonic stem cells in culture. , 1994, Science.

[45]  E. Houssaint Differentiation of the mouse hepatic primordium. II. Extrinsic origin of the haemopoietic cell line. , 1981, Cell differentiation.

[46]  M. Moore,et al.  Role of stem cell migration in initiation of mouse foetal liver haemopoiesis , 1975, Nature.

[47]  A. Silverstein,et al.  FETAL RESPONSE TO ANTIGENIC STIMULUS. IV. REJECTION OF SKIN HOMOGRAFTS BY THE FETAL LAMB. , 1964 .

[48]  D. Traver,et al.  Complex regulation of HSC emergence by the Notch signaling pathway. , 2016, Developmental biology.

[49]  Y. Hanazono,et al.  Long-term follow-up study on the engraftment of human hematopoietic stem cells in sheep. , 2014, Experimental animals.

[50]  Y. Hanazono,et al.  Ex vivo expansion of human HSCs with Sendai virus vector expressing HoxB4 assessed by sheep in utero transplantation. , 2011, Experimental hematology.

[51]  K. Nakagawa,et al.  Zoledronate facilitates large-scale ex vivo expansion of functional gammadelta T cells from cancer patients for use in adoptive immunotherapy. , 2008, Cytotherapy.