The Chemical Constituents and Pharmaco- logical / Biofunctional Effects of Ginger

Zingiber officinale ROSCOE, which belongs to the family of Zingiberaceae, has long been cultivated, and its rhizome ‘ginger’ has been used therapeutically in the world. Traditional medicinal systems have applied this herb to a wide range of illunesses and disorders, including nausea and intestinal disorders. In this review, we described the chemical constituents and their fluctuations during drying and/or heating processes. Furthermore, we summarized the important pharmacological/biofunctional effects of ginger and its pungent constituents (6, 8, 10-gingerols; 6, 8-shogals, etc.) such as antiserotonergic, activation of transient receptor potential vanilloid 1 (TRPV1), antitumor, and antiobesity effects in vivo and/or in vitro.

[1]  T. Maruyama,et al.  Construction of Prediction Models for the Transient Receptor Potential Vanilloid Subtype 1 (TRPV1)-Stimulating Activity of Ginger and Processed Ginger Based on LC-HRMS Data and PLS Regression Analyses. , 2017, Journal of agricultural and food chemistry.

[2]  Chunhua Yang,et al.  Absorption, Metabolic Stability, and Pharmacokinetics of Ginger Phytochemicals , 2017, Molecules.

[3]  T. Kawada,et al.  Direct action of capsaicin in brown adipogenesis and activation of brown adipocytes , 2016, Cell biochemistry and function.

[4]  M. Tuorkey.  Cancer Therapy with Phytochemicals: Present and Future Perspectives. , 2015, Biomedical and environmental sciences : BES.

[5]  T. Hase,et al.  Ginger extract prevents high-fat diet-induced obesity in mice via activation of the peroxisome proliferator-activated receptor δ pathway. , 2015, The Journal of nutritional biochemistry.

[6]  S. Prasad,et al.  Ginger and Its Constituents: Role in Prevention and Treatment of Gastrointestinal Cancer , 2015, Gastroenterology research and practice.

[7]  R. Aneja,et al.  Modulation of Cytochrome P450 Metabolism and Transport across Intestinal Epithelial Barrier by Ginger Biophenolics , 2014, PloS one.

[8]  C. Park,et al.  Ginger and Its Pungent Constituents Non-Competitively Inhibit Serotonin Currents on Visceral Afferent Neurons , 2014, The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology.

[9]  S. Prakash,et al.  Enterohepatic recirculation of bioactive ginger phytochemicals is associated with enhanced tumor growth-inhibitory activity of ginger extract. , 2014, Carcinogenesis.

[10]  B. Murtagh,et al.  Present and Future Perspectives , 2014 .

[11]  D. Julius.  TRP channels and pain. , 2013, Annual review of cell and developmental biology.

[12]  J. Walstab,et al.  Ginger and its pungent constituents non‐competitively inhibit activation of human recombinant and native 5‐HT3 receptors of enteric neurons , 2013, Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.

[13]  A. Roychoudhury,et al.  Ginger consumption enhances the thermic effect of food and promotes feelings of satiety without affecting metabolic and hormonal parameters in overweight men: a pilot study. , 2012, Metabolism: clinical and experimental.

[14]  V. Di Marzo,et al.  Synthesis and biological evaluation of [6]-gingerol analogues as transient receptor potential channel TRPV1 and TRPA1 modulators. , 2012, Bioorganic & medicinal chemistry letters.

[15]  J. Lehmann,et al.  Effects of ginger constituents on the gastrointestinal tract: role of cholinergic M3 and serotonergic 5-HT3 and 5-HT4 receptors. , 2010, Planta medica.

[16]  T. Kono.  [Kampo medicine daikenchuto--Its Exodus from the complementary and alternative medicines]. , 2011, Nihon yakurigaku zasshi. Folia pharmacologica Japonica.

[17]  H. Kuwano,et al.  The effect of traditional Japanese medicine (Kampo) on gastrointestinal function , 2010, Surgery Today.

[18]  A. Oyagbemi,et al.  Molecular targets of [6]‐gingerol: Its potential roles in cancer chemoprevention , 2010, BioFactors.

[19]  J. Ryan,et al.  Treatment of Chemotherapy-Induced Nausea in Cancer Patients. , 2010, European oncology.

[20]  M. Affolter,et al.  Compounds from Sichuan and Melegueta peppers activate, covalently and non‐covalently, TRPA1 and TRPV1 channels , 2009, British journal of pharmacology.

[21]  Sui-qing Mi,et al.  Plasma pharmacokinetics and tissue distribution of [6]‐gingerol in rats , 2008, Biopharmaceutics & drug disposition.

[22]  Chi-Tang Ho,et al.  6-Shogaol suppressed lipopolysaccharide-induced up-expression of iNOS and COX-2 in murine macrophages. , 2008, Molecular nutrition & food research.

[23]  Min-Sook Kang,et al.  6-Shogaol and 6-gingerol, the pungent of ginger, inhibit TNF-alpha mediated downregulation of adiponectin expression via different mechanisms in 3T3-L1 adipocytes. , 2008, Biochemical and biophysical research communications.

[24]  O. Maeda,et al.  Ginger ingredients reduce viability of gastric cancer cells via distinct mechanisms. , 2007, Biochemical and biophysical research communications.

[25]  Jongheon Shin,et al.  Hydroxy‐α‐sanshool activates TRPV1 and TRPA1 in sensory neurons , 2007 .

[26]  A. Szallasi,et al.  The vanilloid receptor TRPV1: 10 years from channel cloning to antagonist proof-of-concept , 2007, Nature Reviews Drug Discovery.

[27]  K. Kobata,et al.  A nonpungent component of steamed ginger—[10]-shogaol—increases adrenaline secretion via the activation of TRPV1 , 2006, Nutritional neuroscience.

[28]  T. Pappas,et al.  The herbal medicine, Dai-Kenchu-to, accelerates delayed gastrointestinal transit after the operation in rats. , 2006, The Journal of surgical research.

[29]  H. Abdel-Aziz,et al.  5-HT3 receptor blocking activity of arylalkanes isolated from the rhizome of Zingiber officinale. , 2005, Planta medica.

[30]  Bruce M. Spiegelman,et al.  Towards a molecular understanding of adaptive thermogenesis , 2000, Nature.

[31]  E. Ernst,et al.  Efficacy of ginger for nausea and vomiting: a systematic review of randomized clinical trials. , 2000, British journal of anaesthesia.

[32]  Y. Gupta,et al.  Antiemetic efficacy of ginger (Zingiber officinale) against cisplatin-induced emesis in dogs. , 1997, Journal of ethnopharmacology.

[33]  K. Kunimi,et al.  Stomachic principles in ginger. III. An anti-ulcer principle, 6-gingesulfonic acid, and three monoacyldigalactosylglycerols, gingerglycolipids A, B, and C, from Zingiberis Rhizoma originating in Taiwan. , 1994, Chemical & pharmaceutical bulletin.

[34]  M. Yoshikawa,et al.  [Qualitative and quantitative analysis of bioactive principles in Zingiberis Rhizoma by means of high performance liquid chromatography and gas liquid chromatography. On the evaluation of Zingiberis Rhizoma and chemical change of constituents during Zingiberis Rhizoma processing]. , 1993, Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan.

[35]  J. Yamahara,et al.  [Stomachic principles in ginger. II. Pungent and anti-ulcer effects of low polar constituents isolated from ginger, the dried rhizoma of Zingiber officinale Roscoe cultivated in Taiwan. The absolute stereostructure of a new diarylheptanoid]. , 1992, Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan.

[36]  M. Yoshikawa,et al.  6-Gingesulfonic acid, a new anti-ulcer principle, and gingerglycolipids A, B, and C, three new monoacyldigalactosylglycerols, from zingiberis rhizoma originating in Taiwan. , 1992, Chemical & pharmaceutical bulletin.

[37]  U. Sankawa,et al.  Inhibition of prostaglandin and leukotriene biosynthesis by gingerols and diarylheptanoids. , 1992, Chemical & pharmaceutical bulletin.

[38]  Q. Huang,et al.  Anti-5-hydroxytryptamine3 effect of galanolactone, diterpenoid isolated from ginger. , 1991, Chemical & pharmaceutical bulletin.

[39]  H. Matsuda,et al.  [The effect of ginger on serotonin induced hypothermia and diarrhea]. , 1990, Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan.

[40]  Yuhao Li,et al.  Gastrointestinal motility enhancing effect of ginger and its active constituents. , 1990, Chemical & pharmaceutical bulletin.

[41]  J. Yamahara,et al.  Inhibition of cytotoxic drug-induced vomiting in suncus by a ginger constituent. , 1989, Journal of ethnopharmacology.

[42]  M. Aburada,et al.  [Pharmacological studies on ginger. V. Pharmacological comparison between (6)-shogaol and capsaicin]. , 1986, Nihon yakurigaku zasshi. Folia pharmacologica Japonica.