Chapter 3 – Breast Cancer

Breast cancer is the most common type of invasive cancer and the second cause of cancer-related death in women. In addition to clinical information, benign findings and pitfalls in fludeoxyglucose (FDG) PET/CT reading, and teaching cases, this chapter reviews evidence-based recommendations regarding PET/CT examination in breast cancer and compares them with statements in major clinical guidelines. According to evidence-based data, FDG PET/CT can potentially replace conventional imaging modalities in staging of locally advanced breast cancer and is recommended for the evaluation of response to chemotherapy or radiation therapy. Interestingly, FDG uptake is higher in patients with triple-negative or HER2-positive malignant lesions and inversely correlates with prognosis.

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