“Gating” of human short-latency somatosensory evoked cortical responses during execution of movement. A high resolution electroencephalography study

The present study aimed at investigating gating of median nerve somatosensory evoked cortical responses (SECRs), estimated during executed continuous complex ipsilateral and contralateral sequential finger movements. SECRs were modeled with an advanced high resolution electroencephalography technology that dramatically improved spatial details of the scalp recorded somatosensory evoked potentials. Integration with magnetic resonance brain images allowed us to localize different SECRs within cortical areas. The working hypothesis was that the gating effects were time varying and could differently influence SECRs. Maximum statistically significant (p<0. 01) time-varying gating (magnitude reduction) of the short-latency SECRs modeled in the contralateral primary motor and somatosensory and supplementary motor areas was computed during the executed ipsilateral movement. The gating effects were stronger on the modeled SECRs peaking 30-45 ms (N30-P30, N32, P45-N45) than 20-26 ms (P20-N20, P22, N26) post-stimulus. Furthermore, the modeled SECRs peaking 30 ms post-stimulus (N30-P30) were significantly increased in magnitude during the executed contralateral movement. These results may delineate a distributed cortical sensorimotor system responsible for the gating effects on SECRs. This system would be able to modulate activity of SECR generators, based on the integration of afferent somatosensory inputs from the stimulated nerve with outputs related to the movement execution.

[1]  S. Jones,et al.  Scalp topography of human somatosensory evoked potentials: the effect of interfering tactile stimulation applied to the hand. , 1984, Electroencephalography and clinical neurophysiology.

[2]  A Urbano,et al.  Human short latency cortical responses to somatosensory stimulation. A high resolution EEG study , 1997, Neuroreport.

[3]  E. Fetz,et al.  Responses of identified cells in postcentral cortex of awake monkeys during comparable active and passive joint movements. , 1980, Journal of neurophysiology.

[4]  Claudio Babiloni,et al.  Responses of human primary sensorimotor and supplementary motor areas to internally triggered unilateral and simultaneous bilateral one‐digit movements. A high‐resolution EEG study , 1998 .

[5]  P. Nunez,et al.  Neocortical Dynamics and Human EEG Rhythms , 1995 .

[6]  P M Rossini,et al.  Brain excitability and long latency muscular arm responses: non-invasive evaluation in healthy and parkinsonian subjects. , 1991, Electroencephalography and clinical neurophysiology.

[7]  P. M. Rossini,et al.  Simultaneous motor output and sensory input: Cortical interference site resolved in humans via neuromagnetic measurements , 1989, Neuroscience Letters.

[8]  A. Ebner,et al.  Frontal and parietal components of enhanced somatosensory evoked potentials: a comparison between pathological and pharmacologically induced conditions. , 1988, Electroencephalography and clinical neurophysiology.

[9]  G Cheron,et al.  Specific gating of the early somatosensory evoked potentials during active movement. , 1987, Electroencephalography and clinical neurophysiology.

[10]  S C Gandevia,et al.  Interfering cutaneous stimulation and the muscle afferent contribution to cortical potentials. , 1988, Electroencephalography and clinical neurophysiology.

[11]  H. Shibasaki,et al.  Electroencephalographic studies of myoclonus. Myoclonus-related cortical spikes and high amplitude somatosensory evoked potentials , 1978 .

[12]  E. Brunko,et al.  The effect of stimulus frequency on post- and pre-central short-latency somatosensory evoked potentials (SEPs). , 1990, Electroencephalography and clinical neurophysiology.

[13]  V. Ibáñez,et al.  Loss of parietal and frontal somatosensory evoked potentials in hemispheric deafferentation. , 1990, Electroencephalography and clinical neurophysiology. Supplement.

[14]  J. Rothwell,et al.  The effect of transcranial magnetic stimulation on median nerve somatosensory evoked potentials. , 1993, Electroencephalography and Clinical Neurophysiology.

[15]  G. Dawson,et al.  INVESTIGATIONS ON A PATIENT SUBJECT TO MYOCLONIC SEIZURES AFTER SENSORY STIMULATION , 1947, Journal of neurology, neurosurgery, and psychiatry.

[16]  K Takeda,et al.  SEPs in two patients with localized lesions of the postcentral gyrus. , 1991, Electroencephalography and clinical neurophysiology.

[17]  J. Tanji,et al.  Reflex and intended responses in motor cortex pyramidal tract neurons of monkey. , 1976, Journal of neurophysiology.

[18]  M. Seyal.  Cortical reflex myoclonus. A study of the relationship between giant somatosensory evoked potentials and motor excitability. , 1991, Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society.

[19]  A. Kimura,et al.  Recovery functions of somatosensory vertex potentials in man: interaction of evoked responses from right and left fingers. , 1991, Electroencephalography and clinical neurophysiology.

[20]  P M Rossini,et al.  Bit-mapped somatosensory evoked potentials and muscular reflex responses in man: comparative analysis in different experimental protocols. , 1990, Electroencephalography and clinical neurophysiology.

[21]  R Hari,et al.  Interaction of afferent impulses in the human primary sensorimotor cortex. , 1992, Electroencephalography and clinical neurophysiology.

[22]  J. Donoghue,et al.  A collateral pathway to the neostriatum from corticofugal neurons of the rat sensory‐motor cortex: An intracellular HRP study , 1981, The Journal of comparative neurology.

[23]  F Mauguière,et al.  Unmasking of cortical SEP components by changes in stimulus rate: a topographic study. , 1992, Electroencephalography and clinical neurophysiology.

[24]  S Tobimatsu,et al.  The interaction of the somatosensory evoked potentials to simultaneous finger stimuli in the human central nervous system. A study using direct recordings. , 1995, Electroencephalography and clinical neurophysiology.

[25]  W. Welker,et al.  SOMATIC SENSORY REPRESENTATION OF FORELIMB IN DORSAL ROOT FIBERS OF RACCOON, COATIMUNDI, AND CAT. , 1965, Journal of neurophysiology.

[26]  P. Rossini,et al.  Topography of spatially enhanced human shortlatency somatosensory evoked potentials , 1997, Neuroreport.

[27]  F Shawkat,et al.  Centrifugal and centripetal mechanisms involved in the 'gating' of cortical SEPs during movement. , 1989, Electroencephalography and clinical neurophysiology.

[28]  C. Marsden,et al.  On the significance of giant somatosensory evoked potentials in cortical myoclonus. , 1984, Journal of neurology, neurosurgery, and psychiatry.

[29]  M. Seyal,et al.  Enhancement of the amplitude of somatosensory evoked potentials following magnetic pulse stimulation of the human brain. , 1993, Electroencephalography and clinical neurophysiology.

[30]  M Scherg,et al.  Somatotopy of human hand somatosensory cortex revealed by dipole source analysis of early somatosensory evoked potentials and 3D-NMR tomography. , 1995, Electroencephalography and clinical neurophysiology.

[31]  A Urbano,et al.  Abnormalities of short-latency somatosensory evoked potentials in parkinsonian patients. , 1989, Electroencephalography and clinical neurophysiology.

[32]  A. Starr,et al.  Vibration and muscle contraction affect somatosensory evoked potentials , 1985, Neurology.

[33]  P M Rossini,et al.  Somatosensory evoked potentials during the ideation and execution of individual finger movements , 1996, Muscle & nerve.

[34]  C. Marsden,et al.  Electrophysiology of somatosensory reflex myoclonus. , 1986, Advances in neurology.

[35]  L. Cohen,et al.  Selectivity of attenuation (i.e., gating) of somatosensory potentials during voluntary movement in humans. , 1987, Electroencephalography and clinical neurophysiology.

[36]  M G Marciani,et al.  Non-invasive evaluation of input-output characteristics of sensorimotor cerebral areas in healthy humans. , 1987, Electroencephalography and clinical neurophysiology.

[37]  F Mauguière,et al.  Astereognosis and dissociated loss of frontal or parietal components of somatosensory evoked potentials in hemispheric lesions. Detailed correlations with clinical signs and computerized tomographic scanning. , 1983, Brain : a journal of neurology.

[38]  R. Forget,et al.  The modulation of somatosensory evoked potentials during the foreperiod of a forewarned reaction time task. , 1993, Electroencephalography and clinical neurophysiology.

[39]  J E Desmedt,et al.  Bit-mapped color imaging of human evoked potentials with reference to the N20, P22, P27 and N30 somatosensory responses. , 1987, Electroencephalography and clinical neurophysiology.

[40]  V. Hömberg,et al.  Modification of cortical somatosensory evoked potentials during tactile exploration and simple active and passive movements. , 1991, Electroencephalography and clinical neurophysiology.

[41]  F. Mauguière,et al.  Mapping study of somatosensory evoked potentials during selective spatial attention. , 1991, Electroencephalography and clinical neurophysiology.

[42]  R Kakigi,et al.  Influence of concurrent tactile stimulation on somatosensory evoked potentials following posterior tibial nerve stimulation in man. , 1986, Electroencephalography and clinical neurophysiology.

[43]  G Cheron,et al.  Gating of the early components of the frontal and parietal somatosensory evoked potentials in different sensory-motor interference modalities. , 1991, Electroencephalography and clinical neurophysiology.

[44]  C. C. Wood,et al.  Tactile interference differentiates sub-components of N20, P20 and P29 in the human cortical surface somatosensory evoked potential. , 1992, Electroencephalography and Clinical Neurophysiology.

[45]  A. Wyler,et al.  Somatosensory evoked potentials after removal of somatosensory cortex in man. , 1986, Electroencephalography and Clinical Neurophysiology.

[46]  L. Deecke,et al.  Somatotopy of human hand somatosensory cortex as studied in scalp EEG. , 1993, Electroencephalography and clinical neurophysiology.

[47]  Stephen J. Jones,et al.  Potentials evoked in human and monkey cerebral cortex by stimulation of the median nerve. A review of scalp and intracranial recordings. , 1991, Brain : a journal of neurology.

[48]  E. Brunko,et al.  Differential effects of isoflurane on SEP recorded over parietal and frontal scalp , 1989, Neurology.

[49]  J C Mazziotta,et al.  Effects of stimulus rate on regional cerebral blood flow after median nerve stimulation. , 1995, Brain : a journal of neurology.

[50]  T Allison,et al.  Localization of functional regions of human mesial cortex by somatosensory evoked potential recording and by cortical stimulation. , 1996, Electroencephalography and clinical neurophysiology.

[51]  R. Nelson.  Activity of monkey primary somatosensory cortical neurons changes prior to active movement , 1987, Brain Research.

[52]  L. Cohen,et al.  Localization, timing and specificity of gating of somatosensory evoked potentials during active movement in man. , 1987, Brain : a journal of neurology.

[53]  C C Wood,et al.  Electrical sources in human somatosensory cortex: identification by combined magnetic and potential recordings. , 1985, Science.

[54]  F Babiloni,et al.  High resolution EEG: a new model-dependent spatial deblurring method using a realistically-shaped MR-constructed subject's head model. , 1997, Electroencephalography and clinical neurophysiology.

[55]  A. Urbano,et al.  Spline Laplacian estimate of EEG potentials over a realistic magnetic resonance-constructed scalp surface model. , 1996, Electroencephalography and clinical neurophysiology.

[56]  C E Schroeder,et al.  Neural generators of early cortical somatosensory evoked potentials in the awake monkey. , 1995, Electroencephalography and clinical neurophysiology.

[57]  G Cheron,et al.  Mental movement simulation affects the N30 frontal component of the somatosensory evoked potential. , 1992, Electroencephalography and clinical neurophysiology.

[58]  E G Jones,et al.  Long-range focal collateralization of axons arising from corticocortical cells in monkey sensory-motor cortex , 1986, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[59]  C Tomberg,et al.  Mapping early somatosensory evoked potentials in selective attention: critical evaluation of control conditions used for titrating by difference the cognitive P30, P40, P100 and N140. , 1989, Electroencephalography and clinical neurophysiology.

[60]  G. Cheron,et al.  Somatosensory evoked potentials at rest and during movement in Parkinson's disease: evidence for a specific apomorphine effect on the frontal N30 wave. , 1994, Electroencephalography and clinical neurophysiology.

[61]  P M Rossini,et al.  Median nerve somatosensory evoked potentials. Apomorphine-induced transient potentiation of frontal components in Parkinson's disease and in parkinsonism. , 1995, Electroencephalography and clinical neurophysiology.

[62]  T. Landis,et al.  Dissociation of frontal and parietal components of somatosensory evoked potentials in severe head injury. , 1993, Electroencephalography and clinical neurophysiology.

[63]  P. Rossini,et al.  Parkinson's disease and somatosensory evoked potentials , 1993, Neurology.