Apodized photon sieves for phase-contrast nano-imaging of living cells

We present a type of diffractive lenses “Zernike apodized photon sieves” (ZAPS), which structure is based on the combination of two concepts: apodized photon sieves and Zernike phase-contrast. In combination with the synchrotron light sources, the ZAPS can be used as an objective for high-resolution X-ray phase-contrast microscopy in physical and life sciences. The ZAPS is a single optic that integrates the appropriate ±π/2 radians phase shift through selective zone placement shifts in an apodized photon sieve. The focusing properties of the ZAPS can be easily controlled by apodizing its pupil function. An apodized photon sieve with Gaussian pupil was fabricated by lithographic technique and showed that the side-lobes have been significantly suppressed at the expense of slightly widening the width of the main lobe.

[1]  Paola Coan,et al.  X-ray phase-contrast imaging: from pre-clinical applications towards clinics , 2013, Physics in medicine and biology.

[2]  Cheng Guan-xiao,et al.  Design and Fabrication of Low-Numerical-Aperture Amplitude-Photon Sieve , 2006 .

[3]  Guo Jinchuan,et al.  A new method of detecting interferogram in differential phase-contrast imaging system based on special structured x-ray scintillator screen , 2010 .

[4]  Zunqi Lin,et al.  Individual far-field model for photon sieves composed of square pinholes. , 2010, Journal of the Optical Society of America. A, Optics, image science, and vision.

[5]  E. Anderson,et al.  Soft X-ray microscopy at a spatial resolution better than 15 nm , 2005, Nature.

[6]  Cheng Guan-xiao,et al.  X-ray Zernike apodized photon sieves for phase-contrast microscopy , 2011 .

[7]  R. L. Johnson,et al.  Sharper images by focusing soft X-rays with photon sieves , 2001, Nature.

[8]  Anne Sakdinawat,et al.  Phase contrast soft x-ray microscopy using Zernike zone plates. , 2008, Optics Express.

[9]  Kazuhiko Omote,et al.  Hard x-ray phase contrast imaging using a tabletop Talbot-Lau interferometer with multiline embedded x-ray targets. , 2013, Optics letters.

[10]  Anne Sakdinawat,et al.  Nanoscale X-ray Imaging , 2009 .

[11]  Ziyu Wu,et al.  Low-dose, simple, and fast grating-based X-ray phase-contrast imaging , 2010, Proceedings of the National Academy of Sciences.

[12]  H. Niu,et al.  Non-absorption grating approach for X-ray phase contrast imaging. , 2011, Optics express.

[13]  A. Takeuchi,et al.  Hard-X-ray phase-difference microscopy using a fresnel zone plate and a transmission grating. , 2009, Physical review letters.

[14]  S. Wilkins,et al.  Phase-contrast imaging of weakly absorbing materials using hard X-rays , 1995, Nature.

[15]  C. Jacobsen,et al.  Zernike phase contrast in scanning microscopy with X-rays. , 2010, Nature physics.

[16]  Hongtao Cui,et al.  X-ray computed tomography in Zernike phase contrast mode at 8 keV with 50-nm resolution using Cu rotating anode X-ray source , 2007 .

[17]  Tingwen Xing,et al.  Zernike apodized photon sieves for high-resolution phase-contrast x-ray microscopy. , 2010, Optics letters.