Biomedical applications of chitin and chitosan based nanomaterials—A short review

Chitin and chitosan are biopolymers having immense structural possibilities for chemical and mechanical modifications to generate novel properties, functions and applications especially in biomedical area. Chitin and chitosan are effective materials for biomedical applications because of their biocompatibility, biodegradability and non-toxicity, apart from their antimicrobial activity and low immunogenicity, which clearly points to an immense potential for future development. These candidate biopolymers can be easily processed into gels, sponges, membranes, beads and scaffolds forms. This review emphasizes recent research on different aspects of chitin and chitosan based nanomaterials, including the preparation and applications of chitin and chitosan based nanofibers, nanoparticles and nanocomposite scaffolds for tissue engineering, wound dressing, drug delivery and cancer diagnosis.

[1]  S. Nair,et al.  Nanocomposite scaffolds of bioactive glass ceramic nanoparticles disseminated chitosan matrix for tissue engineering applications , 2010 .

[2]  Shantikumar V. Nair,et al.  Novel Biodegradable Chitosan-gelatin/nano-bioactive Glass Ceramic Composite Scaffolds for Alveolar Bone Tissue Engineering , 2010 .

[3]  Eduardo Saiz,et al.  Bioactive glass coatings affect the behavior of osteoblast-like cells. , 2007, Acta biomaterialia.

[4]  T. Kokubo,et al.  Bioactive glass ceramics: properties and applications. , 1991, Biomaterials.

[5]  S. Nair,et al.  Novel carboxymethyl derivatives of chitin and chitosan materials and their biomedical applications , 2010 .

[6]  S. Nair,et al.  Novel chitin and chitosan nanofibers in biomedical applications. , 2010, Biotechnology advances.

[7]  S. Nair,et al.  Novel chitin/nanosilica composite scaffolds for bone tissue engineering applications. , 2009, International journal of biological macromolecules.

[8]  M. Bosetti,et al.  The effect of bioactive glasses on bone marrow stromal cells differentiation. , 2005, Biomaterials.

[9]  Shantikumar V. Nair,et al.  Preparation of poly(lactic acid)/chitosan nanoparticles for anti-HIV drug delivery applications , 2010 .

[10]  Jiang Chang,et al.  Preparation and characterization of nano-bioactive-glasses (NBG) by a quick alkali-mediated sol–gel method , 2007 .

[11]  Shantikumar V. Nair,et al.  Preparation and characterization of novel β-chitin/nanosilver composite scaffolds for wound dressing applications , 2010 .

[12]  S. Nair,et al.  Preparation, characterization, bioactive and metal uptake studies of alginate/phosphorylated chitin blend films. , 2009, International journal of biological macromolecules.

[13]  S. Nair,et al.  Bioactive and metal uptake studies of carboxymethyl chitosan-graft-D-glucuronic acid membranes for tissue engineering and environmental applications. , 2009, International journal of biological macromolecules.

[14]  S. Nair,et al.  Development of novel chitin/nanosilver composite scaffolds for wound dressing applications , 2010, Journal of materials science. Materials in medicine.

[15]  R. Reis,et al.  GRAFT COPOLYMERIZED CHITOSAN-PRESENT STATUS AND APPLICATIONS , 2005 .

[16]  Hiroshi Tamura,et al.  Novel biodegradable chitin membranes for tissue engineering applications , 2008 .

[17]  Larry L. Hench,et al.  Genetic design of bioactive glass , 2009 .

[18]  Deepthy Menon,et al.  Bio-conjugated luminescent quantum dots of doped ZnS: a cyto-friendly system for targeted cancer imaging , 2009, Nanotechnology.

[19]  S. Nair,et al.  Development of novel α-chitin/nanobioactive glass ceramic composite scaffolds for tissue engineering applications , 2009 .

[20]  K. Chennazhi,et al.  Chitosan conjugated DNA nanoparticles in gene therapy , 2010 .

[21]  T. Webster,et al.  Enhanced functions of osteoblasts on nanophase ceramics. , 2000, Biomaterials.

[22]  Aldo R Boccaccini,et al.  PDLLA/Bioglass composites for soft-tissue and hard-tissue engineering: an in vitro cell biology assessment. , 2004, Biomaterials.

[23]  B. Toole Cell Biology of Extracellular Matrix , 1981, Springer US.

[24]  Yusuke Yoshihara,et al.  In vitro degradation behavior of freeze-dried carboxymethyl-chitin sponges processed by vacuum-heating and gamma irradiation , 2003 .

[25]  R. Jayakumar,et al.  Chitosan-graft-beta-cyclodextrin scaffolds with controlled drug release capability for tissue engineering applications. , 2009, International journal of biological macromolecules.

[26]  K. Fröberg,et al.  A structural approach to bone adhering of bioactive glasses , 1989 .

[27]  S. Kawakami,et al.  Mannosylated semiconductor quantum dots for the labeling of macrophages. , 2008, Journal of controlled release : official journal of the Controlled Release Society.

[28]  S. Bhatia,et al.  Probing the Cytotoxicity Of Semiconductor Quantum Dots. , 2004, Nano letters.

[29]  Larry L. Hench,et al.  Bioceramics: From Concept to Clinic , 1991 .

[30]  S. Nair,et al.  Folate conjugated carboxymethyl chitosan–manganese doped zinc sulphide nanoparticles for targeted drug delivery and imaging of cancer cells , 2010 .

[31]  J. Mano,et al.  Chitosan-Based Particles as Controlled Drug Delivery Systems , 2004, Drug delivery.

[32]  S. Nair,et al.  Preparation and characterization of novel beta-chitin-hydroxyapatite composite membranes for tissue engineering applications. , 2009, International journal of biological macromolecules.

[33]  J. Tanaka,et al.  Synergistic effect of silanol group and calcium ion in chitosan membrane on apatite forming ability in simulated body fluid , 2006, Journal of biomaterials science. Polymer edition.

[34]  S. Nair,et al.  Synthesis, characterization, cytotoxicity and antibacterial studies of chitosan, O-carboxymethyl and N,O-carboxymethyl chitosan nanoparticles , 2009 .

[35]  Hae-Won Kim,et al.  Membrane of hybrid chitosan-silica xerogel for guided bone regeneration. , 2009, Biomaterials.

[36]  S. Nair,et al.  Preparation and characterization of chitosan–gelatin/nanohydroxyapatite composite scaffolds for tissue engineering applications , 2010 .

[37]  S. Nair,et al.  Electrospinning of carboxymethyl chitin/poly(vinyl alcohol) nanofibrous scaffolds for tissue engineering applications , 2009 .

[38]  Shantikumar V. Nair,et al.  Mannosylated chitosan-zinc sulphide nanocrystals as fluorescent bioprobes for targeted cancer imaging , 2011 .

[39]  R. Jayakumar,et al.  Sulfated chitin and chitosan as novel biomaterials. , 2007, International journal of biological macromolecules.

[40]  T. Kokubo Surface chemistry of bioactive glass-ceramics , 1990 .

[41]  M. Rai,et al.  Silver nanoparticles as a new generation of antimicrobials. , 2009, Biotechnology advances.

[42]  Rui L. Reis,et al.  Phosphorous Containing Chitosan Beads for Controlled Oral Drug Delivery , 2006 .

[43]  R. Jayakumar,et al.  Synthesis, Characterization and Biospecific Degradation Behavior of Sulfated Chitin , 2008 .

[44]  S. Mcloughlin,et al.  Differential healing response of bone adjacent to porous implants coated with hydroxyapatite and 45S5 bioactive glass. , 2001, Journal of biomedical materials research.

[45]  M. Leite,et al.  The effect of ionic products from bioactive glass dissolution on osteoblast proliferation and collagen production. , 2004, Biomaterials.

[46]  S. Nair,et al.  Novel carboxymethyl chitin nanoparticles for cancer drug delivery applications , 2010 .

[47]  G. Borchard Chitosans for gene delivery. , 2001, Advanced drug delivery reviews.

[48]  K. Nakanishi,et al.  Apatite Formation Induced by Silica Gel in a Simulated Body Fluid , 1992 .