COLONIC CARCINOMA AND ULCERATIVE COLITIS. MULTIFOCAL CARCINOMA OCCURRING AFTER LONG REMISSION OF COLITIS.

A relationship between chronic ulcerative colitis and the subsequent development of carcinoma of the colon has been well established. 1-9 It has been emphasized that onset of ulcerative colitis in childhood, 8-14 duration of activity of the colitis, 8-10,15 and severity of symptoms 10 appear to be predisposing factors to neoplastic change. A relationship between pseudopolyposis and malignant degeneration has not been confirmed. 7,10,15-17 Although it has been stated that ulcerative colitis may be quiescent at the time of recognition of colonic carcinoma, 15,17,18 in our opinion, this point has not received sufficient emphasis. Accordingly, we are reporting a case in which, after more than 16 years of total remission of ulcerative colitis, con- firmed both clinically and proctoscopically, carcinoma of the colon was detected on routine examination. Report of a Case A 23-year-old man was initially examined at the Cleveland Clinic on July 3, 1933, because of diarrhea consisting

[1]  J. A. Bargen,et al.  The nature of the carcinoma associated with ulcerative colitis , 1962, Diseases of the colon and rectum.

[2]  R. Gage,et al.  The prognosis of chronic ulcerative colitis in children. , 1961, The New England journal of medicine.

[3]  B. Brooke.  Malignant change in ulcerative colitis , 1961, Diseases of the colon and rectum.

[4]  M. Sleisenger,et al.  Ulcerative colitis with onset after the age fifty. , 1961, Gastroenterology.

[5]  N. Edling,et al.  Distribution of malignancy in ulcerative colitis. , 1961, Gastroenterology.

[6]  W. Sauer,et al.  The roentgenologic features of carcinoma in chronic ulcerative colitis. , 1961, The American journal of roentgenology, radium therapy, and nuclear medicine.

[7]  T. Arajarvi,et al.  Ulcerative colitis in children. A clinical, psychological and social follow-up study. , 1961, Annales paediatriae Fenniae.

[8]  E. Kiefer,et al.  Arrested Chronic Ulcerative Colitis , 1960 .

[9]  Bargen Ja,et al.  Carcinoma and ulcerative colitis: prognosis. , 1960 .

[10]  P. Benson,et al.  Ulcerative colitis in childhood. A study of its natural history. , 1960, The Quarterly journal of medicine.

[11]  I. Dawson,et al.  The development of carcinoma of the large intestine in ulcerative colitis , 1959, Proceedings of the Royal Society of Medicine.

[12]  Lindner Ae,et al.  Chronic ulcerative colitis in childhood: a follow-up study. , 1959 .

[13]  J. Kirsner,et al.  Carcinoma and ulcerative colitis, a clinical-pathologic study. II. Statistical analysis. , 1958, Gastroenterology.

[14]  J. Kirsner,et al.  Carcinoma and ulcerative colitis, a clinical-pathologic study. I. Cancer deaths. , 1958, Gastroenterology.

[15]  J. Beattie,et al.  Carcinoma complicating ulcerative colitis during childhood. , 1956, American journal of clinical pathology.

[16]  R. Warren,et al.  Ulcerative colitis; follow-up studies. , 1955, The New England journal of medicine.

[17]  J. A. Bargen,et al.  The development of cancer in chronic ulcerative colitis. , 1954, Gastroenterology.

[18]  C. Dukes,et al.  The association of chronic ulcerative colitis and carcinoma of the rectum and colon , 1952, The British journal of surgery.

[19]  A. Johnson,et al.  Malignant degeneration in chronic ulcerative colitis. , 1951, Gastroenterology.

[20]  C. Brown,et al.  Carcinoma of the colon complicating chronic ulcerative colitis. , 1950, Gastroenterology.

[21]  J. Felsen,et al.  Chronic ulcerative colitis and carcinoma. , 1949, Archives of internal medicine.

[22]  M. Brown,et al.  Malignant degeneration in ulcerative colitis; report of seven cases. , 1949, The Medical clinics of North America.

[23]  J. A. Bargen,et al.  STUDIES ON THE LIFE HISTORIES OF PATIENTS WITH CHRONIC ULCERATIVE COLITIS (THROMBO-ULCERATIVE COLITIS), WITH SOME SUGGESTIONS FOR TREATMENT , 1938 .