Prospective Assessment of the Rockall Risk Scoring System in Egyptian Patients with Upper Gastrointestinal Bleeding

Background: One of the major challenges in managing acute upper gastrointestinal bleeding involves the identification of patients who are at high risk of rebleeding and death; conversely, the identification of patients who are suitable for early discharge and outpatient endoscopy is also important for effective resource. The use of Rockall system has been shown to represent accurate and valid predictor of rebleeding and death. The aim of this prospective study was to evaluate validity of Rockall score for prediction of rebleeding and mortality in Egyptian patients with upper gastrointestinal bleeding. Patients and Methods: 50 patients presented with upper GI bleeding were subjected to detailed clinical, laboratory, sonographic and endoscopic examination together with Rockall score calculation. Results: According to the findings of upper GI endoscopy patients were further subdivided into two subgroups as follows: Group 1 (n = 32): Patients with portal hypertension manifested by variceal bleeding and/or portal hypertensive gastropathy; and Group 2 (n = 18): other causes of acute upper gastrointestinal bleeding (peptic ulcer disease, Mallory Weiss syndrome…). Clinical condition of the patients was assessed after 48 hours and mortality was recorded. Rockall score was the highest in mortality group, and higher in rebleeding group than stable group (P < 0.01). Rockall score was higher in Child C than Child B and Child A among hepatic patients (P < 0.01). The cutoff value of Rockall score = 3.5 was the best for prediction of rebleeding with sensitivity 100%, specificity 53%, while the cutoff value = 6.5 was the best for prediction of mortality with sensitivity 100% and 93.5% specificity. Conclusion: Rockall score is clinically useful in prediction of rebleeding and mortality in patients with upper gastrointestinal bleeding. It can accurately differentiate between patients with stable condition that could be discharged from hospital and those who require hospitalization and this could help to minimize hospital stay and cost.

[1]  A. Axon,et al.  Predictors of mortality in patients with acute upper gastrointestinal hemorrhage who underwent endoscopy and confirmed to have variceal hemorrhage , 2015 .

[2]  Khairy H Morsy,et al.  Outcomes and predictors of in-hospital mortality among cirrhotic patients with non-variceal upper gastrointestinal bleeding in upper Egypt. , 2015, The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology.

[3]  V. Ahuja,et al.  Clinical and endoscopic profile of patients with upper gastrointestinal bleeding at tertiary care center of North India , 2014, Journal of Digestive Endoscopy.

[4]  K. Kessels,et al.  Prediction scores or gastroenterologists’ Gut Feeling for triaging patients that present with acute upper gastrointestinal bleeding , 2014, United European gastroenterology journal.

[5]  L. Abu-Raddad,et al.  The epidemiology of hepatitis C virus in Egypt: a systematic review and data synthesis , 2013, BMC Infectious Diseases.

[6]  Jian Qin,et al.  Rockall score in predicting outcomes of elderly patients with acute upper gastrointestinal bleeding. , 2013, World journal of gastroenterology.

[7]  J. Reynolds,et al.  Upper gastrointestinal bleeding: predictors of risk in a mixed patient group including variceal and nonvariceal haemorrhage , 2012, European journal of gastroenterology & hepatology.

[8]  D. García-Compeán,et al.  Nonvariceal upper gastrointestinal bleeding in patients with liver cirrhosis. Clinical features, outcomes and predictors of in-hospital mortality. A prospective study. , 2011, Annals of hepatology.

[9]  N. Pausawasdi,et al.  Characteristics and outcomes of acute upper gastrointestinal bleeding after therapeutic endoscopy in the elderly. , 2011, World journal of gastroenterology.

[10]  S. Travis,et al.  Acute upper gastrointestinal bleeding in the UK: patient characteristics, diagnoses and outcomes in the 2007 UK audit , 2011, Gut.

[11]  Am Masaad,et al.  Rockall score of the acute upper gastrointestinal bleeding patients the experience in Sudan , 2009 .

[12]  Shandana Tarique,et al.  Comparison of MELD, Child Pugh score and Rockall score for predicting rebleeding and in-hospital mortality in patients of variceal bleeding. , 2008, Journal of the College of Physicians and Surgeons--Pakistan : JCPSP.

[13]  M. E. Leerdam Epidemiology of acute upper gastrointestinal bleeding. , 2008 .

[14]  B. Enestvedt,et al.  An evaluation of endoscopic indications and findings related to nonvariceal upper-GI hemorrhage in a large multicenter consortium. , 2008, Gastrointestinal endoscopy.

[15]  S. Kim,et al.  [Comparison of predictive factors related to the mortality and rebleeding caused by variceal bleeding: Child-Pugh score, MELD score, and Rockall score]. , 2002, Taehan Kan Hakhoe chi = The Korean journal of hepatology.

[16]  S. Cross,et al.  Prospective validation of the Rockall risk scoring system for upper GI hemorrhage in subgroups of patients with varices and peptic ulcers , 2002, American Journal of Gastroenterology.

[17]  C. Terwee,et al.  Validation of the Rockall risk scoring system in upper gastrointestinal bleeding , 1999, Gut.

[18]  T. Rockall,et al.  Influencing the practice and outcome in acute upper gastrointestinal haemorrhage , 1997, Gut.

[19]  T. C. Northfield,et al.  Selection of patients for early discharge or outpatient care after acute upper gastrointestinal haemorrhage , 1996, The Lancet.

[20]  H B Devlin,et al.  Risk assessment after acute upper gastrointestinal haemorrhage. , 1996, Gut.

[21]  Amith Kumar,et al.  Predictors of In-hospital Mortality Among Patients Presenting with Variceal Gastrointestinal Bleeding , 2015, Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association.

[22]  D. Balaban,et al.  Predictors for in-hospital mortality and need for clinical intervention in upper GI bleeding: a 5-year observational study. , 2014, Chirurgia.

[23]  E. Lang,et al.  Emergency department risk stratification in upper gastrointestinal bleeding. , 2012, CJEM.