Mediterranean diet and mobility decline in older persons

We examined whether adherence to a Mediterranean-style diet has positive effects on mobility assessed over a 9-year follow-up in a representative sample of older adults. This research is part of the InCHIANTI Study, a prospective population-based study of older persons in Tuscany, Italy. The sample for this analysis included 935 women and men aged 65 years and older. Adherence to the Mediterranean diet was assessed at baseline by the standard 10-unit Mediterranean diet score (MDS). Lower extremity function was measured at baseline, and at the 3-, 6- and 9-year follow-up visits using the short physical performance battery (SPPB). At baseline, higher adherence to Mediterranean diet was associated with better lower body performance. Participants with higher adherence experienced less decline in SPPB score, which was of 0.9 points higher (p<.0001) at the 3-year-follow, 1.1 points higher (p=0.0004) at the 6-year follow-up and 0.9 points higher (p=0.04) at the 9-year follow-up compared to those with lower adherence. Among participants free of mobility disability at baseline, those with higher adherence had a lower risk (HR=0.71, 95% CI=0.51-0.98, p=0.04) of developing new mobility disability. High adherence to a Mediterranean-style diet is associated with a slower decline of mobility over time in community-dwelling older persons. If replicated, this observation is highly relevant in terms of public health.

[1]  Rosanna Abbate,et al.  Adherence to Mediterranean diet and health status: meta-analysis , 2008, BMJ : British Medical Journal.

[2]  M. Delgado-Rodríguez,et al.  Association of the Mediterranean dietary pattern with the incidence of depression: the Seguimiento Universidad de Navarra/University of Navarra follow-up (SUN) cohort. , 2009, Archives of general psychiatry.

[3]  P. Mecocci,et al.  Age-dependent increases in oxidative damage to DNA, lipids, and proteins in human skeletal muscle. , 1999, Free radical biology & medicine.

[4]  Dolores Corella,et al.  Effects of a Mediterranean-Style Diet on Cardiovascular Risk Factors , 2006, Annals of Internal Medicine.

[5]  Tina Costacou,et al.  Adherence to a Mediterranean diet and survival in a Greek population. , 2003, The New England journal of medicine.

[6]  L. Ferrucci,et al.  Antioxidants and physical performance in elderly persons: the Invecchiare in Chianti (InCHIANTI) study. , 2004, The American journal of clinical nutrition.

[7]  Katherine Esposito,et al.  Effect of a mediterranean-style diet on endothelial dysfunction and markers of vascular inflammation in the metabolic syndrome: a randomized trial. , 2004 .

[8]  Virginie Rondeau,et al.  Adherence to a Mediterranean diet, cognitive decline, and risk of dementia. , 2009, JAMA.

[9]  S. Mayne,et al.  Antioxidant nutrients and chronic disease: use of biomarkers of exposure and oxidative stress status in epidemiologic research. , 2003, The Journal of nutrition.

[10]  M. Lawton,et al.  Assessment of Older People: Self-Maintaining and Instrumental Activities of Daily Living , 1969 .

[11]  A. Trichopoulou,et al.  Mediterranean diet and survival among patients with coronary heart disease in Greece. , 2005, Archives of internal medicine.

[12]  J. Twisk,et al.  Longitudinal Data Analysis. A Comparison Between Generalized Estimating Equations and Random Coefficient Analysis , 2003, European Journal of Epidemiology.

[13]  S. Cole,et al.  Overadjustment Bias and Unnecessary Adjustment in Epidemiologic Studies , 2009, Epidemiology.

[14]  Luigi Ferrucci,et al.  Subsystems Contributing to the Decline in Ability to Walk: Bridging the Gap Between Epidemiology and Geriatric Practice in the InCHIANTI Study , 2000, Journal of the American Geriatrics Society.

[15]  E. Benvenuti,et al.  Measuring muscular strength of the lower limbs by hand-held dynamometer: A standard protocol , 1999, Aging.

[16]  D. Annane,et al.  Corticosteroids for severe sepsis and septic shock: a systematic review and meta-analysis , 2004, BMJ : British Medical Journal.

[17]  L. Ferrucci,et al.  Low serum carotenoids and development of severe walking disability among older women living in the community: the women's health and aging study I. , 2006, Age and ageing.

[18]  F Berrino,et al.  Relative validity and reproducibility of a food frequency dietary questionnaire for use in the Italian EPIC centres. , 1997, International journal of epidemiology.

[19]  S. Bandinelli,et al.  Low nutrient intake is an essential component of frailty in older persons. , 2006, The journals of gerontology. Series A, Biological sciences and medical sciences.

[20]  R B Wallace,et al.  Lower-extremity function in persons over the age of 70 years as a predictor of subsequent disability. , 1995, The New England journal of medicine.

[21]  L. Ferrucci,et al.  Inflammatory markers and physical performance in older persons: the InCHIANTI study. , 2004, The journals of gerontology. Series A, Biological sciences and medical sciences.

[22]  J. van Limbeek,et al.  Criterion validity of the Center for Epidemiologic Studies Depression scale (CES-D): results from a community-based sample of older subjects in The Netherlands. , 1997, Psychological medicine.

[23]  S. Studenski,et al.  Meaningful Change and Responsiveness in Common Physical Performance Measures in Older Adults , 2006, Journal of the American Geriatrics Society.

[24]  Linda P. Fried,et al.  The Women's Health and Aging Study: Health and Social Characteristics of Older Women with Disability , 1995 .

[25]  E. Keller,et al.  Age-associated increased interleukin-6 gene expression, late-life diseases, and frailty. , 2000, Annual review of medicine.

[26]  S. Bandinelli,et al.  Carotenoids as protection against disability in older persons. , 2008, Rejuvenation research.

[27]  A. Naska,et al.  Conformity to traditional Mediterranean diet and cancer incidence: the Greek EPIC cohort , 2008, British Journal of Cancer.

[28]  J F Sallis,et al.  Compendium of physical activities: classification of energy costs of human physical activities. , 1993, Medicine and science in sports and exercise.

[29]  S. Bandinelli,et al.  Use of the Short Physical Performance Battery Score to predict loss of ability to walk 400 meters: analysis from the InCHIANTI study. , 2009, The journals of gerontology. Series A, Biological sciences and medical sciences.

[30]  L. Ferrucci,et al.  A short physical performance battery assessing lower extremity function: association with self-reported disability and prediction of mortality and nursing home admission. , 1994, Journal of gerontology.

[31]  L. Radloff The CES-D Scale , 1977 .

[32]  S. Bandinelli,et al.  Serum micronutrient concentrations and decline in physical function among older persons. , 2008, JAMA.

[33]  L. Serra-Majem,et al.  Effectiveness of the Mediterranean diet in the elderly , 2008, Clinical interventions in aging.

[34]  M. Martínez-González,et al.  Adherence to Mediterranean diet and risk of developing diabetes: prospective cohort study , 2008, BMJ : British Medical Journal.

[35]  S. Bandinelli,et al.  Low plasma carotenoids and skeletal muscle strength decline over 6 years. , 2008, The journals of gerontology. Series A, Biological sciences and medical sciences.