Senescence surveillance of pre-malignant hepatocytes limits liver cancer development

[1]  J. Rockstroh,et al.  HIV and cancer in Germany. , 2011, Deutsches Arzteblatt international.

[2]  S. Lowe,et al.  Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas , 2011, Nature.

[3]  Thomas J. Fuchs,et al.  TAK1 suppresses a NEMO-dependent but NF-kappaB-independent pathway to liver cancer. , 2010, Cancer cell.

[4]  Manuel T. Silva.  When two is better than one: macrophages and neutrophils work in concert in innate immunity as complementary and cooperative partners of a myeloid phagocyte system , 2010, Journal of leukocyte biology.

[5]  Deborah M. Brown,et al.  Cytolytic CD4 cells: Direct mediators in infectious disease and malignancy. , 2010, Cellular immunology.

[6]  D. Peeper,et al.  Oncogene-Induced Senescence Relayed by an Interleukin-Dependent Inflammatory Network , 2008, Cell.

[7]  Jonathan Melamed,et al.  Chemokine Signaling via the CXCR2 Receptor Reinforces Senescence , 2008, Cell.

[8]  T. Böhler,et al.  Reconstitution of immunodeficient SCID/beige mice with human cells: applications in preclinical studies. , 2008, Toxicology.

[9]  M. Frid,et al.  Hypoxia-induced pulmonary vascular remodeling requires recruitment of circulating mesenchymal precursors of a monocyte/macrophage lineage. , 2006, The American journal of pathology.

[10]  Corey M. Carlson,et al.  Somatic integration of an oncogene-harboring Sleeping Beauty transposon models liver tumor development in the mouse. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[11]  S. Lowe,et al.  Senescence comes of age , 2005, Nature Medicine.

[12]  M. Taketo,et al.  Hepatocarcinogenesis in Mice with β-Catenin and Ha-Ras Gene Mutations , 2004, Cancer Research.

[13]  T. Jacks,et al.  Acute mutation of retinoblastoma gene function is sufficient for cell cycle re-entry , 2003, Nature.

[14]  R. Bernards,et al.  Reversal of Senescence in Mouse Fibroblasts through Lentiviral Suppression of p53* 210 , 2003, The Journal of Biological Chemistry.

[15]  B. Pearce.  Models and Mechanisms , 2003 .

[16]  M. Vasseur-Cognet,et al.  A tamoxifen‐inducible chimeric Cre recombinase specifically effective in the fetal and adult mouse liver , 2002, Hepatology.

[17]  T. Jacks,et al.  Analysis of lung tumor initiation and progression using conditional expression of oncogenic K-ras. , 2001, Genes & development.

[18]  J. Campisi,et al.  Senescent fibroblasts promote epithelial cell growth and tumorigenesis: A link between cancer and aging , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[19]  Richard A. Ashmun,et al.  Tumor Suppression at the Mouse INK4a Locus Mediated by the Alternative Reading Frame Product p19 ARF , 1997, Cell.

[20]  Asim Khwaja,et al.  Matrix adhesion and Ras transformation both activate a phosphoinositide 3‐OH kinase and protein kinase B/Akt cellular survival pathway , 1997, The EMBO journal.

[21]  D. M. Carlson,et al.  Gene expression following direct injection of DNA into liver. , 1994, Human gene therapy.

[22]  W. Uttal.  On models and mechanisms , 1992, Behavioral and Brain Sciences.

[23]  P. M. Rao,et al.  Liver tumour promotion by chemicals: models and mechanisms. , 1986, Cancer surveys.