Stereotactic lung irradiation in mice promotes long-term senescence and lung injury.

[1]  F. Milliat,et al.  Lung Stereotactic Arc Therapy in Mice: Development of Radiation Pneumopathy and Influence of HIF-1α Endothelial Deletion. , 2019, International journal of radiation oncology, biology, physics.

[2]  Jacqueline P. Williams,et al.  Modeling radiation-induced lung injury: lessons learned from whole thorax irradiation , 2018, International journal of radiation biology.

[3]  F. Milliat,et al.  The importance of the vascular endothelial barrier in the immune-inflammatory response induced by radiotherapy. , 2018, The British journal of radiology.

[4]  F. Milliat,et al.  Importance of dosimetry protocol for cell irradiation on a low X-rays facility and consequences for the biological response , 2018, International journal of radiation biology.

[5]  J. Gil,et al.  Mechanisms and functions of cellular senescence. , 2018, The Journal of clinical investigation.

[6]  E. O'Duibhir,et al.  Paracrine cellular senescence exacerbates biliary injury and impairs regeneration , 2018, Nature Communications.

[7]  E. Deutsch,et al.  CSF1R inhibition prevents radiation pulmonary fibrosis by depletion of interstitial macrophages , 2018, European Respiratory Journal.

[8]  J. Hesser,et al.  Using immunotherapy to boost the abscopal effect , 2018, Nature Reviews Cancer.

[9]  Manish R. Sharma,et al.  Safety and Clinical Activity of Pembrolizumab and Multisite Stereotactic Body Radiotherapy in Patients With Advanced Solid Tumors. , 2018, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[10]  P. Validire,et al.  mTOR pathway activation drives lung cell senescence and emphysema. , 2018, JCI insight.

[11]  M. Rojas,et al.  IPF lung fibroblasts have a senescent phenotype. , 2017, American journal of physiology. Lung cellular and molecular physiology.

[12]  F. Milliat,et al.  Conditional Plasminogen Activator Inhibitor Type 1 Deletion in the Endothelial Compartment Has No Beneficial Effect on Radiation-Induced Whole-Lung Damage in Mice. , 2017, International journal of radiation oncology, biology, physics.

[13]  H. Onishi,et al.  Stereotactic body radiotherapy for early stage lung cancer-historical developments and future strategies. , 2017, Chinese clinical oncology.

[14]  Sanjiv J. Shah,et al.  A null mutation in SERPINE1 protects against biological aging in humans , 2017, Science Advances.

[15]  D. Citrin,et al.  Inhibition of Bcl-2/xl With ABT-263 Selectively Kills Senescent Type II Pneumocytes and Reverses Persistent Pulmonary Fibrosis Induced by Ionizing Radiation in Mice. , 2017, International journal of radiation oncology, biology, physics.

[16]  Wiggert A. van Cappellen,et al.  Targeted Apoptosis of Senescent Cells Restores Tissue Homeostasis in Response to Chemotoxicity and Aging , 2017, Cell.

[17]  A. Oberg,et al.  Cellular senescence mediates fibrotic pulmonary disease , 2017, Nature Communications.

[18]  P. Barnes.  Senescence in COPD and Its Comorbidities. , 2017, Annual review of physiology.

[19]  B. Kennedy,et al.  Cellular Senescence Promotes Adverse Effects of Chemotherapy and Cancer Relapse. , 2017, Cancer discovery.

[20]  C. Simone,et al.  Stereotactic Radiotherapy for Stage I Small Cell Lung Cancer , 2016, The oncologist.

[21]  M. Story,et al.  Time, Dose, and Volume Responses in a Mouse Pulmonary Injury Model Following Ablative Irradiation , 2016, Lung.

[22]  M. Iruela-Arispe,et al.  In vivo evidence for an endothelium-dependent mechanism in radiation-induced normal tissue injury , 2015, Scientific Reports.

[23]  F. Milliat,et al.  Identification of Endothelial-to-Mesenchymal Transition as a Potential Participant in Radiation Proctitis. , 2015, The American journal of pathology.

[24]  N. Sharpless,et al.  Forging a signature of in vivo senescence , 2015, Nature Reviews Cancer.

[25]  Min Yao,et al.  Complications from Stereotactic Body Radiotherapy for Lung Cancer , 2015, Cancers.

[26]  E. Tartour,et al.  Synergy of Radiotherapy and a Cancer Vaccine for the Treatment of HPV-Associated Head and Neck Cancer , 2015, Molecular Cancer Therapeutics.

[27]  J. Hoeijmakers,et al.  An essential role for senescent cells in optimal wound healing through secretion of PDGF-AA. , 2014, Developmental cell.

[28]  R. Timmerman,et al.  Emergence of stereotactic body radiation therapy and its impact on current and future clinical practice. , 2014, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[29]  V. Krizhanovsky,et al.  Physiological and pathological consequences of cellular senescence , 2014, Cellular and Molecular Life Sciences.

[30]  A Preclinical Rodent Model of Acute Radiation-Induced Lung Injury after Ablative Focal Irradiation Reflecting Clinical Stereotactic Body Radiotherapy , 2014, Radiation research.

[31]  Jung Il Lee,et al.  Development of a small animal model to simulate clinical stereotactic body radiotherapy-induced central and peripheral lung injuries , 2014, Journal of radiation research.

[32]  U. Shankavaram,et al.  Role of type II pneumocyte senescence in radiation-induced lung fibrosis. , 2013, Journal of the National Cancer Institute.

[33]  David B. Darr,et al.  Monitoring Tumorigenesis and Senescence In Vivo with a p16 INK4a -Luciferase Model , 2013, Cell.

[34]  Jaeho Cho,et al.  High dose-per-fraction irradiation of limited lung volumes using an image-guided, highly focused irradiator: simulating stereotactic body radiotherapy regimens in a small-animal model. , 2010, International journal of radiation oncology, biology, physics.

[35]  D. Peeper,et al.  Senescence-messaging secretome: SMS-ing cellular stress , 2009, Nature Reviews Cancer.

[36]  G. Hannon,et al.  A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4 , 1993, Nature.