Sestrin2-mediated disassembly of stress granules dampens aerobic glycolysis to overcome glucose starvation

[1]  Xiaodong Sun,et al.  A paradoxical role for sestrin 2 protein in tumor suppression and tumorigenesis , 2021, Cancer cell international.

[2]  S. Qin,et al.  m6A reader IGF2BP2-stabilized CASC9 accelerates glioblastoma aerobic glycolysis by enhancing HK2 mRNA stability , 2021, Cell death discovery.

[3]  N. Chandel,et al.  Cancer metabolism: looking forward , 2021, Nature Reviews Cancer.

[4]  Ziqiang Wang,et al.  Splicing factor SRSF2-centric gene regulation , 2021, International journal of biological sciences.

[5]  Q. Ding,et al.  SARS-CoV-2 nucleocapsid protein phase separates with G3BPs to disassemble stress granules and facilitate viral production , 2021, Science Bulletin.

[6]  Shizhen Zhang,et al.  The Metabolic Mechanisms of Breast Cancer Metastasis , 2021, Frontiers in Oncology.

[7]  Weiguo Lu,et al.  CircCDKN2B-AS1 interacts with IMP3 to stabilize hexokinase 2 mRNA and facilitate cervical squamous cell carcinoma aerobic glycolysis progression , 2020, Journal of Experimental & Clinical Cancer Research.

[8]  Yuanyuan Shi,et al.  Initiation of stress granule assembly by rapid clustering of IGF2BP proteins upon osmotic shock. , 2020, Biochimica et biophysica acta. Molecular cell research.

[9]  K. Scotlandi,et al.  IGF2BP3 From Physiology to Cancer: Novel Discoveries, Unsolved Issues, and Future Perspectives , 2020, Frontiers in Cell and Developmental Biology.

[10]  C. Frezza.  Metabolism and cancer: the future is now , 2019, British Journal of Cancer.

[11]  Yong-ming Yao,et al.  Sestrin2: Its Potential Role and Regulatory Mechanism in Host Immune Response in Diseases , 2019, Front. Immunol..

[12]  D. Veale,et al.  STAT3 Mediates the Differential Effects of Oncostatin M and TNFα on RA Synovial Fibroblast and Endothelial Cell Function , 2019, Front. Immunol..

[13]  Michael Sattler,et al.  Combinatorial recognition of clustered RNA elements by the multidomain RNA-binding protein IMP3 , 2019, Nature Communications.

[14]  Xiang Xue,et al.  The interaction of Hemin and Sestrin2 modulates oxidative stress and colon tumor growth. , 2019, Toxicology and applied pharmacology.

[15]  Changwei Qiu,et al.  Targeting the ROS/PI3K/AKT/HIF‐1α/HK2 axis of breast cancer cells: Combined administration of Polydatin and 2‐Deoxy‐d‐glucose , 2019, Journal of cellular and molecular medicine.

[16]  Ying-jian Liang,et al.  Gankyrin drives metabolic reprogramming to promote tumorigenesis, metastasis and drug resistance through activating β-catenin/c-Myc signaling in human hepatocellular carcinoma. , 2019, Cancer letters.

[17]  Siyuan Liu,et al.  Blockade of miR-3614 maturation by IGF2BP3 increases TRIM25 expression and promotes breast cancer cell proliferation , 2019, EBioMedicine.

[18]  A. Newton,et al.  Apical-basal polarity inhibits Epithelial-Mesenchymal Transition and tumour metastasis via PAR complex-mediated SNAI1 degradation , 2019, Nature Cell Biology.

[19]  Xukun Deng,et al.  Dauricine upregulates the chemosensitivity of hepatocellular carcinoma cells: Role of repressing glycolysis via miR-199a:HK2/PKM2 modulation. , 2018, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

[20]  J. Chao,et al.  Structural basis of IMP3 RRM12 recognition of RNA , 2018, RNA: A publication of the RNA Society.

[21]  Xingdong Zhou,et al.  Chloroquine inhibits autophagic flux by decreasing autophagosome-lysosome fusion , 2018, Autophagy.

[22]  Hailing Shi,et al.  Author Correction: Recognition of RNA N6-methyladenosine by IGF2BP proteins enhances mRNA stability and translation , 2018, Nature Cell Biology.

[23]  C. Shaha,et al.  Sestrin2 facilitates glutamine‐dependent transcription of PGC‐1α and survival of liver cancer cells under glucose limitation , 2018, The FEBS journal.

[24]  Christopher P. Long,et al.  Hexokinase-2 depletion inhibits glycolysis and induces oxidative phosphorylation in hepatocellular carcinoma and sensitizes to metformin , 2018, Nature Communications.

[25]  Matthias W. Hentze,et al.  A brave new world of RNA-binding proteins , 2018, Nature Reviews Molecular Cell Biology.

[26]  H. Yao,et al.  BAG3 directly stabilizes Hexokinase 2 mRNA and promotes aerobic glycolysis in pancreatic cancer cells , 2017, The Journal of cell biology.

[27]  Jianfang Liu,et al.  Recent Insights into the Biological Functions of Sestrins in Health and Disease , 2017, Cellular Physiology and Biochemistry.

[28]  Jean-Baptiste Morlot,et al.  P-Body Purification Reveals the Condensation of Repressed mRNA Regulons. , 2017, Molecular cell.

[29]  C. Brangwynne,et al.  Liquid phase condensation in cell physiology and disease , 2017, Science.

[30]  A. Eid,et al.  Sestrin2 as a Novel Biomarker and Therapeutic Target for Various Diseases , 2017, Oxidative medicine and cellular longevity.

[31]  Vladimir N Uversky,et al.  Intrinsically disordered proteins in overcrowded milieu: Membrane-less organelles, phase separation, and intrinsic disorder. , 2017, Current opinion in structural biology.

[32]  S. Ki,et al.  Sestrin2 inhibits hypoxia-inducible factor-1α accumulation via AMPK-mediated prolyl hydroxylase regulation. , 2016, Free radical biology & medicine.

[33]  A. Goffeau,et al.  The HK2 Dependent “Warburg Effect” and Mitochondrial Oxidative Phosphorylation in Cancer: Targets for Effective Therapy with 3-Bromopyruvate , 2016, Molecules.

[34]  M. Cecchini,et al.  Ultrastructural Characterization of the Lower Motor System in a Mouse Model of Krabbe Disease , 2016, Scientific Reports.

[35]  R. Parker,et al.  Principles and Properties of Stress Granules. , 2016, Trends in cell biology.

[36]  K. Gourgoulianis,et al.  Sestrin-2 is significantly increased in malignant pleural effusions due to lung cancer and is potentially secreted by pleural mesothelial cells. , 2016, Clinical biochemistry.

[37]  B. Blencowe,et al.  IGF2BP3 Modulates the Interaction of Invasion-Associated Transcripts with RISC. , 2016, Cell reports.

[38]  K. Taniuchi,et al.  KIF20A-Mediated RNA Granule Transport System Promotes the Invasiveness of Pancreatic Cancer Cells1 , 2014, Neoplasia.

[39]  Li-Ju Chang,et al.  Hexokinase 2-mediated Warburg effect is required for PTEN- and p53-deficiency-driven prostate cancer growth. , 2014, Cell reports.

[40]  K. Taniuchi,et al.  IGF2BP3-mediated translation in cell protrusions promotes cell invasiveness and metastasis of pancreatic cancer , 2014, Oncotarget.

[41]  T. Hansen,et al.  IMP3 RNP safe houses prevent miRNA-directed HMGA2 mRNA decay in cancer and development. , 2014, Cell reports.

[42]  M. Karin,et al.  Sestrins orchestrate cellular metabolism to attenuate aging. , 2013, Cell metabolism.

[43]  I. Ben-Sahra,et al.  Sestrin2 integrates Akt and mTOR signaling to protect cells against energetic stress-induced death , 2012, Cell Death and Differentiation.

[44]  Stefan Hüttelmaier,et al.  Insulin-like growth factor 2 mRNA-binding proteins (IGF2BPs): post-transcriptional drivers of cancer progression? , 2012, Cellular and Molecular Life Sciences.

[45]  Mark Ellisman,et al.  Maintenance of metabolic homeostasis by Sestrin2 and Sestrin3. , 2012, Cell metabolism.

[46]  Jirun Peng,et al.  Reduced survival of patients with hepatocellular carcinoma expressing hexokinase II , 2012, Medical Oncology.

[47]  P. Ward,et al.  Metabolic reprogramming: a cancer hallmark even warburg did not anticipate. , 2012, Cancer cell.

[48]  M. Birnbaum,et al.  PPARγ contributes to PKM2 and HK2 expression in fatty liver , 2012, Nature Communications.

[49]  A. Budanov.  Stress-responsive sestrins link p53 with redox regulation and mammalian target of rapamycin signaling. , 2011, Antioxidants & redox signaling.

[50]  D. Hanahan,et al.  Hallmarks of Cancer: The Next Generation , 2011, Cell.

[51]  Y. Surh,et al.  Nrf2-Mediated heme oxygenase-1 upregulation as adaptive survival response to glucose deprivation-induced apoptosis in HepG2 cells. , 2010, Antioxidants & redox signaling.

[52]  N. Hay,et al.  FoxOs inhibit mTORC1 and activate Akt by inducing the expression of Sestrin3 and Rictor. , 2010, Developmental cell.

[53]  Mark H. Ellisman,et al.  Sestrin as a Feedback Inhibitor of TOR That Prevents Age-Related Pathologies , 2010, Science.

[54]  Saroj P. Mathupala,et al.  Hexokinase-2 bound to mitochondria: cancer's stygian link to the "Warburg Effect" and a pivotal target for effective therapy. , 2009, Seminars in cancer biology.

[55]  N. Hay,et al.  Akt determines replicative senescence and oxidative or oncogenic premature senescence and sensitizes cells to oxidative apoptosis. , 2008, Cancer cell.

[56]  A. Chajut,et al.  Identification of a novel stress-responsive gene Hi95 involved in regulation of cell viability , 2002, Oncogene.