Glucocorticoid regulation of plasma ketone body concentration in insulin devicient man.

This study was designed to assess the hyperketonemic activity of glucocorticoids in insulin deficient diabetic man. Both the duration of exposure and the site of action of glucocorticoids were examined relative to a significant increase in plasma ketone body concentration. Six stable insulin dependent diabetic subjects participated in a control, an acute glucocorticoid exposure, and a prolonged glucocorticoid exposure study. For the control study, no glucocorticoids were administered before or during the study. During the acute glucocorticoid exposure study, acute hypercortisolemia was induced for 80 min by the bolus iv administration of 50 mg of cortisol. In the prolonged glucocorticoid exposure study, 24 h of prolonged glucocorticoid stimulation was produced by the oral administration of 1.0 mg of dexamethasone, at 24 and 12 h prior to study. During these studies, a hepatic stimulating effect of glucocorticoids independent of the free fatty acid mobilization activity of glucocorticoids was assessed by a...

[1]  R. Eaton,et al.  Modulation of Fatty Acid Metabolism by Glucagon in Man: IV. Effects of a Physiologic Hormone Infusion in Normal Man , 1976, Diabetes.

[2]  J. McGarry,et al.  Ketogenesis and its regulation. , 1976, The American journal of medicine.

[3]  P. Cryer,et al.  The role of adrenergic mechanisms in the substrate and hormonal response to insulin-induced hypoglycemia in man. , 1976, The Journal of clinical investigation.

[4]  A. Kitabchi,et al.  The efficacy of low-dose versus conventional therapy of insulin for treatment of diabetic ketoacidosis. , 1976, Annals of internal medicine.

[5]  S. Filetti,et al.  Growth Hormone Levels in Diabetes: Correlation with the Clinical Control of the Disease , 1976, Diabetes.

[6]  A. Fauci,et al.  Glucocorticosteroid therapy: mechanisms of action and clinical considerations. , 1976, Annals of internal medicine.

[7]  T. B. Miller,et al.  Carbohydrate metabolism in perfused livers of adrenalectomized and steroid-replaced rats. , 1976, The American journal of physiology.

[8]  J. Olefsky.  Effect of dexamethasone on insulin binding, glucose transport, and glucose oxidation of isolated rat adipocytes. , 1975, The Journal of clinical investigation.

[9]  R. Eaton,et al.  Glucagon regulation of plasma ketone body concentration in human diabetes. , 1975, The Journal of clinical investigation.

[10]  F. H. Tyler,et al.  Apparently normal pituitary-adrenal suppressibility in Cushing's syndrome: dexamethasone metabolism and plasma levels. , 1975, The Journal of laboratory and clinical medicine.

[11]  J. McGarry,et al.  Hormonal control of ketogenesis. Rapid activation of hepatic ketogenic capacity in fed rats by anti-insulin serum and glucagon. , 1975, The Journal of clinical investigation.

[12]  Eaton Rp,et al.  Modulation of fatty acid metabolism by glucagon in man. I. Effects in normal subjects. , 1975 .

[13]  G. Reaven,et al.  The effects of acute and chronic dexamethasone administration on insulin binding to isolated rat hepatocytes and adipocytes. , 1975, Metabolism: clinical and experimental.

[14]  R. T. Dunn,et al.  Single-antibody technique for radioimmunoassay of cortisol in unextracted serum or plasma. , 1974, Clinical chemistry.

[15]  S. Ebers,et al.  The influence of intravenously administered cortisol--with and without the addition of insulin or pretreatment with propranolol--on various parameters of fat and carbohydrate metabolism in blood plasma of human beings. , 1974, Acta endocrinologica. Supplementum.

[16]  B. Jaffe,et al.  Methods of Hormone Radioimmunoassay , 1974 .

[17]  K. Mashimo,et al.  A Simple Method for the Determination of Serum Free Insulin Levels in Insulin-treated Patients , 1973, Diabetes.

[18]  Eaton Rp.  Glucagon secretion and activity in the cobalt chloride-treated rat , 1973 .

[19]  E. Gordon,et al.  Ketoacidosis associated with alcoholism in nondiabetic subjects. , 1973, Annals of internal medicine.

[20]  W. A. Müller,et al.  Hyperglucagonemia in diabetic ketoacidosis. Its prevalence and significance. , 1973, The American journal of medicine.

[21]  G D Molnar,et al.  Plasma immunoreactive insulin patterns in insulin-treated diabetics. Studies during continuous blood glucose monitoring. , 1972, Mayo Clinic proceedings.

[22]  R. J. Dudl,et al.  Use of benzamidine as a proteolytic inhibitor in the radioimmunoassay of glucagon in plasma. , 1972, The Journal of clinical endocrinology and metabolism.

[23]  M. Heimberg,et al.  Hepatic metabolism of free fatty acids in experimental diabetes. , 1972, Israel journal of medical sciences.

[24]  J. Gerich,et al.  Clinical and Metabolic Characteristics of Hyperosmolar Nonketotic Coma , 1971, Diabetes.

[25]  R. Havel,et al.  Evidence for an effect of inulin on the peripheral utilization of ketone bodies in dogs. , 1971, The Journal of clinical investigation.

[26]  A. Bahn.  Basic medical statistics. 1. , 1969, Journal of the American Medical Women's Association.

[27]  A. Drash,et al.  Cortisol secretion in acidotic and nonacidotic juvenile diabetes mellitus. , 1969, The Journal of pediatrics.

[28]  Duncombe Wg.  The colorimetric micro-determination of long-chain fatty acids. , 1963 .

[29]  P. J. Randle,et al.  Immunoassay of insulin with insulin antibody preciptate. , 1963, Lancet.

[30]  V. Dole,et al.  Microdetermination of long-chain fatty acids in plasma and tissues. , 1960, The Journal of biological chemistry.

[31]  H. Kistler,et al.  EFFECTS OF ANTI‐INFLAMMATORY STEROIDS ON CARBOHYDRATE METABOLISM, WITH EMPHASIS ON HYPO‐GLYCEMIC AND DIABETIC STATES * , 1959, Annals of the New York Academy of Sciences.

[32]  A. Huggett,et al.  Use of glucose oxidase, peroxidase, and O-dianisidine in determination of blood and urinary glucose. , 1957, Lancet.

[33]  D. Munro,et al.  Addison's disease with diabetes mellitus; a case treated with cortisone. , 1954, Lancet.