Comparing Methods for Determining Motor-Hand Lateralization Based on fTCD Signals

The lateralization index (LI) as determined from functional transcranial Doppler sonography (fTCD) can be used to determine the hemispheric organization of neural activation during a behavioral task. Previous studies have proposed different methods to determine this index, but to our knowledge no studies have compared the performance of these methods. In this study, we compare two established methods with a simpler method proposed here. The aim was to see whether similar results could be achieved with a simpler method and to give an indication of the analysis steps required to determine the LI. A simple unimanual motor task was performed while fTCD was acquired, and the LI determined by each of these methods was compared. In addition, LI determined by each method was related to behavioural output in the form of degree of handedness. The results suggest that although the methods differed in complexity, they yielded similar results when determining the lateralization of motor functions, and its correlation with behavior. Further investigation is needed to expand the conclusions of this preliminary study, however the new method proposed in the paper has great potential as it is much simpler than the more established methods yet yields similar results.

[1]  Franco Lepore,et al.  Non-invasive alternatives to the Wada test in the presurgical evaluation of language and memory functions in epilepsy patients. , 2007, Epileptic disorders : international epilepsy journal with videotape.

[2]  A Schnitzler,et al.  Handedness and asymmetry of hand representation in human motor cortex. , 1998, Journal of neurophysiology.

[3]  Tracy Wolff,et al.  Screening for carotid artery stenosis. , 2015, American family physician.

[4]  Tom Chau,et al.  Towards a multimodal brain–computer interface: Combining fNIRS and fTCD measurements to enable higher classification accuracy , 2013, NeuroImage.

[5]  Byoung-Kyong Min,et al.  Neuroimaging-based approaches in the brain-computer interface. , 2010, Trends in biotechnology.

[6]  R. C. Oldfield.  The assessment and analysis of handedness: the Edinburgh inventory. , 1971, Neuropsychologia.

[7]  Michael Deppe,et al.  The investigation of functional brain lateralization by transcranial Doppler sonography , 2004, NeuroImage.

[8]  D. Mozaffarian,et al.  Heart disease and stroke statistics--2011 update: a report from the American Heart Association. , 2011, Circulation.

[9]  K Willmes,et al.  Determination of cognitive hemispheric lateralization by "functional" transcranial Doppler cross-validated by functional MRI. , 1999, Stroke.

[10]  Irene Katzan,et al.  Guidelines for prevention of stroke in patients with ischemic stroke or transient ischemic attack: a statement for healthcare professionals from the American Heart Association/American Stroke Association Council on Stroke: co-sponsored by the Council on Cardiovascular Radiology and Intervention: the , 2006, Stroke.

[11]  Selami Serhatlio.  Classification of Transcranial Doppler Signals Using Artificial Neural Network , 2003 .

[12]  J. Martí-Fàbregas,et al.  THE STROKE OUTCOMES AND NEUROIMAGING OF INTRACRANIAL ATHEROSCLEROSIS (SONIA) TRIAL , 2007 .

[13]  K. McFarland,et al.  Factor stability of the Edinburgh Handedness Inventory as a function of test-retest performance, age and sex , 1980 .

[14]  S. Levine,et al.  The Stroke Outcomes and Neuroimaging of Intracranial Atherosclerosis ( SONIA ) , 2007 .

[15]  G Bernardi,et al.  Bilateral hemispheric activation in the early recovery of motor function after stroke. , 1998, Stroke.

[16]  M Deppe,et al.  Determination of cognitive hemispheric lateralization by "functional" transcranial Doppler cross-validated by functional MRI. , 1999, Stroke.

[17]  Susanne Knake,et al.  Language lateralization in children using functional transcranial Doppler sonography , 2010, Developmental medicine and child neurology.

[18]  Ram Frost,et al.  Comparison of the geometric and the contrast models of similarity by presentation of visual stimuli to the left and the right visual fields , 1989, Brain and Cognition.

[19]  R. Schandry,et al.  Deficient adjustment of cerebral blood flow to cognitive activity due to chronically low blood pressure , 2006, Biological Psychology.

[20]  M Verdino,et al.  Two Measures of Laterality in Handedness: The Edinburgh Handedness Inventory and the Purdue Pegboard Test of Manual Dexterity , 1998, Perceptual and motor skills.

[21]  Tom Chau,et al.  A Brain-Computer Interface Based on Bilateral Transcranial Doppler Ultrasound , 2011, PloS one.

[22]  S G Kim,et al.  Functional activation in motor cortex reflects the direction and the degree of handedness. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[23]  H. Lohmann,et al.  Language lateralization in young children assessed by functional transcranial Doppler sonography , 2005, NeuroImage.

[24]  Firat Hardalaç,et al.  Comparison of MLP Neural Network and Neuro-fuzzy System in Transcranial Doppler Signals Recorded from the Cerebral Vessels , 2008, Journal of Medical Systems.

[25]  Dorothy V. M. Bishop,et al.  Assessment of Cerebral Lateralization in Children using Functional Transcranial Doppler Ultrasound (fTCD) , 2010, Journal of visualized experiments : JoVE.

[26]  M Deppe,et al.  Noninvasive determination of language lateralization by functional transcranial Doppler sonography: a comparison with the Wada test. , 1998, Stroke.

[27]  Annika Plate,et al.  Determination of Hemispheric Dominance with Mental Rotation Using Functional Transcranial Doppler Sonography and fMRI , 2011, Journal of neuroimaging : official journal of the American Society of Neuroimaging.

[28]  Janine Reis,et al.  Language dominance in mesial temporal lobe epilepsy: A functional transcranial Doppler sonography study of brain plasticity , 2006, Epilepsy & Behavior.

[29]  Stefan Knecht,et al.  Functional transcranial Doppler sonography. , 2006, Frontiers of neurology and neuroscience.

[30]  Hakan Isik,et al.  An Artificial Neural Network Classification Approach for use the Ultrasound in Physiotherapy , 2011, Journal of Medical Systems.

[31]  Stephen M. Williams,et al.  Handedness inventories: Edinburgh versus Annett. , 1991 .

[32]  C. Caltagirone,et al.  Functional transcranial Doppler assessment of cerebral blood flow velocities changes during attention tasks , 2009, European journal of neurology.

[33]  Dorothy V.M. Bishop,et al.  Lateralised visual attention is unrelated to language lateralisation, and not influenced by task difficulty – A functional transcranial Doppler study , 2012, Neuropsychologia.

[34]  R. Aaslid,et al.  Noninvasive transcranial Doppler ultrasound recording of flow velocity in basal cerebral arteries. , 1982, Journal of neurosurgery.

[35]  Rachel Fazio,et al.  The original instructions for the Edinburgh Handedness Inventory are misunderstood by a majority of participants , 2012, Laterality.

[36]  Dorothy V.M. Bishop,et al.  An efficient and reliable method for measuring cerebral lateralization during speech with functional transcranial Doppler ultrasound , 2009, Neuropsychologia.

[37]  B J Ransil,et al.  Test-Retest Reliability of the Edinburgh Handedness Inventory and Global Handedness Preference Measurements, and Their Correlation , 1994, Perceptual and motor skills.

[38]  Janine Reis,et al.  Ictal functional TCD for the lateralization of the seizure onset zone—a report of two cases , 2004, Epilepsy Research.

[39]  S. Knake,et al.  Functional transcranial Doppler sonography and a spatial orientation paradigm identify the non-dominant hemisphere , 2008, Brain and Cognition.

[40]  Inan Güler,et al.  A Survey on Application of Quantitative Methods on Analysis of Brain Parameters Changing with Temperature , 2010, Journal of Medical Systems.