The molecular basis of T helper 1 and T helper 2 cell differentiation.

[1]  R. de Waal Malefyt,et al.  IL-18 Receptors, Their Role in Ligand Binding and Function: Anti-IL-1RAcPL Antibody, a Potent Antagonist of IL-181 , 2000, The Journal of Immunology.

[2]  Naoko Arai,et al.  Gata-3 Induces T Helper Cell Type 2 (Th2) Cytokine Expression and Chromatin Remodeling in Committed Th1 Cells , 2000, The Journal of experimental medicine.

[3]  A. Rao,et al.  Cell-type-restricted binding of the transcription factor NFAT to a distal IL-4 enhancer in vivo. , 2000, Immunity.

[4]  W. Miller,et al.  Identification of a coordinate regulator of interleukins 4, 13, and 5 by cross-species sequence comparisons. , 2000, Science.

[5]  Laurie H Glimcher,et al.  A Novel Transcription Factor, T-bet, Directs Th1 Lineage Commitment , 2000, Cell.

[6]  P. Bork,et al.  The p150-Spir protein provides a link between c-Jun N-terminal kinase function and actin reorganization , 2000, Current Biology.

[7]  G. Trinchieri,et al.  Cutting Edge: Ectopic Expression of the IL-12 Receptor-β2 in Developing and Committed Th2 Cells Does Not Affect the Production of IL-4 or Induce the Production of IFN-γ1 , 2000, The Journal of Immunology.

[8]  R. Nishikomori,et al.  T Helper Type 2 Cell Differentiation Occurs in the Presence of Interleukin 12 Receptor β2 Chain Expression and Signaling , 2000, The Journal of experimental medicine.

[9]  H. Lee,et al.  Ectopic expression of activated Stat6 induces the expression of Th2-specific cytokines and transcription factors in developing Th1 cells. , 1999, Immunity.

[10]  Andreas Radbruch,et al.  Instruction for Cytokine Expression in T Helper Lymphocytes in Relation to Proliferation and Cell Cycle Progression , 1999, The Journal of experimental medicine.

[11]  D. H. Zhang,et al.  Inhibition of allergic inflammation in a murine model of asthma by expression of a dominant-negative mutant of GATA-3. , 1999, Immunity.

[12]  R. Coffman,et al.  Impaired NFATc translocation and failure of Th2 development in Itk-deficient CD4+ T cells. , 1999, Immunity.

[13]  J. Siekierka,et al.  p38α Mitogen-Activated Protein Kinase Is Activated by CD28-Mediated Signaling and Is Required for IL-4 Production by Human CD4+CD45RO+ T Cells and Th2 Effector Cells , 1999, The Journal of Immunology.

[14]  L. Glimcher,et al.  The transcription factor c-Maf controls the production of interleukin-4 but not other Th2 cytokines. , 1999, Immunity.

[15]  J A Gustafsson,et al.  Seeking Ligands for Lonely Orphan Receptors , 1999, Science.

[16]  R. Coffman,et al.  Instruction, Selection, or Tampering with the Odds? , 1999, Science.

[17]  H. Lee,et al.  GATA-3 significantly downregulates IFN-gamma production from developing Th1 cells in addition to inducing IL-4 and IL-5 levels. , 1999, Clinical immunology.

[18]  M. Cameron,et al.  p38 Mitogen-Activated Protein Kinase Mediates Signal Integration of TCR/CD28 Costimulation in Primary Murine T Cells , 1999, Journal of Immunology.

[19]  W. Ouyang,et al.  The Ets transcription factor ERM is Th1-specific and induced by IL-12 through a Stat4-dependent pathway. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[20]  M. Jackson,et al.  Intercellular adhesion molecule-1 inhibits interleukin 4 production by naive T cells. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[21]  E. Coccia,et al.  Interleukin-12 Induces Expression of Interferon Regulatory Factor-1 via Signal Transducer and Activator of Transcription-4 in Human T Helper Type 1 Cells* , 1999, The Journal of Biological Chemistry.

[22]  N. Kadowaki,et al.  Reciprocal control of T helper cell and dendritic cell differentiation. , 1999, Science.

[23]  B. Pulendran,et al.  Distinct dendritic cell subsets differentially regulate the class of immune response in vivo. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[24]  R. Maldonado-López,et al.  CD8α+ and CD8α− Subclasses of Dendritic Cells Direct the Development of Distinct T Helper Cells In Vivo , 1999, The Journal of experimental medicine.

[25]  R. Flavell,et al.  Regulation of IL‐4 expression by the transcription factor JunB during T helper cell differentiation , 1999, The EMBO journal.

[26]  W. M. Weaver,et al.  The Roles of Nuclear Factor of Activated T Cells and Ying-Yang 1 in Activation-induced Expression of the Interferon-γ Promoter in T Cells* , 1998, The Journal of Biological Chemistry.

[27]  M. Biffi,et al.  References Subscriptions Permissions Email Alerts The Role of Stat4 in Species-Specific Regulation of Th Cell Development by Type I , 2013 .

[28]  R. Flavell,et al.  Defective T cell differentiation in the absence of Jnk1. , 1998, Science.

[29]  Suneet Agarwal,et al.  Modulation of chromatin structure regulates cytokine gene expression during T cell differentiation. , 1998, Immunity.

[30]  K. Arai,et al.  Th2-specific DNase I-hypersensitive sites in the murine IL-13 and IL-4 intergenic region. , 1998, International immunology.

[31]  J. Bluestone,et al.  LFA-1 interaction with ICAM-1 and ICAM-2 regulates Th2 cytokine production. , 1998, Journal of Immunology.

[32]  L. Glimcher,et al.  Inhibitory function of two NFAT family members in lymphoid homeostasis and Th2 development. , 1998, Immunity.

[33]  W. Ouyang,et al.  Inhibition of Th1 development mediated by GATA-3 through an IL-4-independent mechanism. , 1998, Immunity.

[34]  I. McInnes,et al.  Selective Expression and Functions of Interleukin 18 Receptor on T Helper (Th) Type 1 but not Th2 Cells , 1998, The Journal of experimental medicine.

[35]  G. Peltz,et al.  GATA-3-dependent enhancer activity in IL-4 gene regulation. , 1998, Journal of immunology.

[36]  D. H. Zhang,et al.  Differential responsiveness of the IL-5 and IL-4 genes to transcription factor GATA-3. , 1998, Journal of immunology.

[37]  R. Flavell,et al.  Differentiation of CD4+ T cells to Th1 cells requires MAP kinase JNK2. , 1998, Immunity.

[38]  S. Akira,et al.  IL-12 up-regulates IL-18 receptor expression on T cells, Th1 cells, and B cells: synergism with IL-18 for IFN-gamma production. , 1998, Journal of immunology.

[39]  R M Locksley,et al.  Independent and epigenetic regulation of the interleukin-4 alleles in CD4+ T cells. , 1998, Science.

[40]  P. Hodgkin,et al.  Cell division regulates the T cell cytokine repertoire, revealing a mechanism underlying immune class regulation. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[41]  Chyung-Ru Wang,et al.  Helper T cell differentiation is controlled by the cell cycle. , 1998, Immunity.

[42]  S. Agarwal,et al.  Long-range transcriptional regulation of cytokine gene expression. , 1998, Current opinion in immunology.

[43]  H. Okamura,et al.  Regulation of interferon-γ production by IL-12 and IL-18 , 1998 .

[44]  M. Su,et al.  Interferon‐γ expression by Th1 effector T cells mediated by the p38 MAP kinase signaling pathway , 1998, The EMBO journal.

[45]  K. Arai,et al.  Characterization of cis-regulatory elements and nuclear factors conferring Th2-specific expression of the IL-5 gene: a role for a GATA-binding protein. , 1998, Journal of immunology.

[46]  S. Akira,et al.  Defective NK cell activity and Th1 response in IL-18-deficient mice. , 1998, Immunity.

[47]  A. O’Garra,et al.  Cytokines induce the development of functionally heterogeneous T helper cell subsets. , 1998, Immunity.

[48]  A. Sher,et al.  In Vivo Microbial Stimulation Induces Rapid CD40 Ligand–independent Production of Interleukin 12 by Dendritic Cells and their Redistribution to T Cell Areas , 1997, The Journal of experimental medicine.

[49]  A. Rao,et al.  Down-regulation of IL-4 gene transcription and control of Th2 cell differentiation by a mechanism involving NFAT1. , 1997, Immunity.

[50]  L. Steinman,et al.  CD4+ T-cell subsets in autoimmunity. , 1997, Current opinion in immunology.

[51]  S. Szabo,et al.  Genes that regulate interleukin-4 expression in T cells. , 1997, Current opinion in immunology.

[52]  A. Sica,et al.  Interaction of NF-κB and NFAT with the Interferon-γ Promoter* , 1997, The Journal of Biological Chemistry.

[53]  R. Flavell,et al.  T-cell subsets: transcriptional control in the Th1/Th2 decision. , 1997, Current biology : CB.

[54]  K. Torigoe,et al.  Purification and Characterization of the Human Interleukin-18 Receptor* , 1997, The Journal of Biological Chemistry.

[55]  R. Kastelein,et al.  IGIF Does Not Drive Th1 Development but Synergizes with IL-12 for Interferon-γ Production and Activates IRAK and NFκB , 1997 .

[56]  A. Ray,et al.  Transcription Factor GATA-3 Is Differentially Expressed in Murine Th1 and Th2 Cells and Controls Th2-specific Expression of the Interleukin-5 Gene* , 1997, The Journal of Biological Chemistry.

[57]  S. Orkin,et al.  A "knockdown" mutation created by cis-element gene targeting reveals the dependence of erythroid cell maturation on the level of transcription factor GATA-1. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[58]  T. Mak,et al.  Interferon regulatory factor-1 is required for a T helper 1 immune response in vivo. , 1997, Immunity.

[59]  T. Taniguchi,et al.  Multistage regulation of Th1-type immune responses by the transcription factor IRF-1. , 1997, Immunity.

[60]  Richard A Flavell,et al.  The Transcription Factor GATA-3 Is Necessary and Sufficient for Th2 Cytokine Gene Expression in CD4 T Cells , 1997, Cell.

[61]  K. Frazer,et al.  Computational and biological analysis of 680 kb of DNA sequence from the human 5q31 cytokine gene cluster region. , 1997, Genome research.

[62]  S. Szabo,et al.  Regulation of the Interleukin (IL)-12R β2 Subunit Expression in Developing T Helper 1 (Th1) and Th2 Cells , 1997, The Journal of experimental medicine.

[63]  M. Biffi,et al.  Selective Expression of an Interleukin-12 Receptor Component by Human T Helper 1 Cells , 1997, The Journal of experimental medicine.

[64]  J. Bluestone,et al.  CD28 costimulation promotes the production of Th2 cytokines. , 1997, Journal of immunology.

[65]  T. Aune,et al.  Differential transcription directed by discrete gamma interferon promoter elements in naive and memory (effector) CD4 T cells and CD8 T cells , 1997, Molecular and cellular biology.

[66]  W. M. Weaver,et al.  The Proximal Regulatory Element of the Interferon-γ Promoter Mediates Selective Expression in T Cells* , 1996, The Journal of Biological Chemistry.

[67]  Kenneth M. Murphy,et al.  Functional diversity of helper T lymphocytes , 1996, Nature.

[68]  J. Ye,et al.  The nuclear factor YY1 suppresses the human gamma interferon promoter through two mechanisms: inhibition of AP1 binding and activation of a silencer element , 1996, Molecular and cellular biology.

[69]  C. Thompson,et al.  Limited role of CD28-mediated signals in T helper subset differentiation , 1996, The Journal of experimental medicine.

[70]  T. Hoey,et al.  Cooperative DNA Binding and Sequence-Selective Recognition Conferred by the STAT Amino-Terminal Domain , 1996, Science.

[71]  G. Schuler,et al.  High level IL-12 production by murine dendritic cells: upregulation via MHC class II and CD40 molecules and downregulation by IL-4 and IL-10 [published erratum appears in J Exp Med 1996 Oct 1;184(4):following 1590] , 1996, The Journal of experimental medicine.

[72]  A. Lanzavecchia,et al.  Ligation of CD40 on dendritic cells triggers production of high levels of interleukin-12 and enhances T cell stimulatory capacity: T-T help via APC activation , 1996, The Journal of experimental medicine.

[73]  H. Young,et al.  Regulation of interferon-gamma gene expression. , 1996, Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research.

[74]  P. Doherty,et al.  Requirement for Stat4 in interleukin-12-mediated responses of natural killer and T cells , 1996, Nature.

[75]  M. Kaplan,et al.  Impaired IL-12 responses and enhanced development of Th2 cells in Stat4-deficient mice , 1996, Nature.

[76]  Laurie H Glimcher,et al.  The Proto-Oncogene c-maf Is Responsible for Tissue-Specific Expression of Interleukin-4 , 1996, Cell.

[77]  Anjana Rao,et al.  An Enhanced Immune Response in Mice Lacking the Transcription Factor NFAT1 , 1996, Science.

[78]  D. Carvajal,et al.  IL-12-Deficient Mice Are Defective in IFNγ Production and Type 1 Cytokine Responses , 1996 .

[79]  S. Akira,et al.  Essential role of Stat6 in IL-4 signalling , 1996, Nature.

[80]  W. Paul,et al.  Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted State6 gene , 1996, Nature.

[81]  L. Glimcher,et al.  Hyperproliferation and dysregulation of IL-4 expression in NF-ATp-deficient mice. , 1996, Immunity.

[82]  J. Pimm,et al.  Identification of a calcium-inducible, cyclosporine sensitive element in the IFN-gamma promoter that is a potential NFAT binding site. , 1996, Transplantation.

[83]  M. Kaplan,et al.  Stat6 is required for mediating responses to IL-4 and for development of Th2 cells. , 1996, Immunity.

[84]  K. Murphy,et al.  Reversibility of T helper 1 and 2 populations is lost after long-term stimulation , 1996, The Journal of experimental medicine.

[85]  T. Mosmann,et al.  The expanding universe of T-cell subsets: Th1, Th2 and more. , 1996, Immunology today.

[86]  W. Paul,et al.  Growth and gene expression are predominantly controlled by distinct regions of the human IL-4 receptor. , 1996, Immunity.

[87]  H. Okamura,et al.  Cloning of a new cytokine that induces IFN-γ production by T cells , 1995, Nature.

[88]  M. Siegel,et al.  Activation of the Interleukin-5 Promoter by cAMP in Murine EL-4 Cells Requires the GATA-3 and CLE0 Elements (*) , 1995, The Journal of Biological Chemistry.

[89]  H. Dienes,et al.  Uptake of microparticle‐adsorbed protein antigen by bone marrow‐derived dendritic cells results in up‐regulation of interleukin‐1α and interleukin‐12 p40/p35 and triggers prolonged, efficient antigen presentation , 1995, European journal of immunology.

[90]  S. Szabo,et al.  Developmental commitment to the Th2 lineage by extinction of IL-12 signaling. , 1995, Immunity.

[91]  G. Trinchieri,et al.  Dendritic cells produce IL-12 and direct the development of Th1 cells from naive CD4+ T cells. , 1995, Journal of immunology.

[92]  A. Abbas,et al.  Stability of Th1 and Th2 populations. , 1995, International immunology.

[93]  J. W. Rooney,et al.  Coordinate and cooperative roles for NF-AT and AP-1 in the regulation of the murine IL-4 gene. , 1995, Immunity.

[94]  R. Coffman,et al.  Induction of a Th2 population from a polarized Leishmania-specific Th1 population by in vitro culture with IL-4. , 1995, Journal of immunology.

[95]  S. McKnight,et al.  An interleukin-4-induced transcription factor: IL-4 Stat. , 1994, Science.

[96]  W. Paul,et al.  Lymphocyte responses and cytokines , 1994, Cell.

[97]  W. M. Weaver,et al.  Two essential regulatory elements in the human interferon gamma promoter confer activation specific expression in T cells , 1993, The Journal of experimental medicine.

[98]  R. Coffman,et al.  Cytokine regulation of T-cell function: potential for therapeutic intervention. , 1993, Immunology today.

[99]  Martin Bachmann,et al.  Disruption of the murine IL-4 gene blocks Th2 cytokine responses , 1993, Nature.

[100]  M. F. Shannon,et al.  The granulocyte-macrophage colony-stimulating factor/interleukin 3 locus is regulated by an inducible cyclosporin A-sensitive enhancer. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[101]  S. Orkin.  GATA-binding transcription factors in hematopoietic cells , 1992 .

[102]  F. Finkelman,et al.  The Importance of Th2 Cytokines in Protective Immunity to Nematodes , 1992, Immunological reviews.

[103]  S. Durham,et al.  Predominant TH2-like bronchoalveolar T-lymphocyte population in atopic asthma. , 1992, The New England journal of medicine.

[104]  K. Rajewsky,et al.  Generation and analysis of interleukin-4 deficient mice. , 1991, Science.

[105]  A. Weinberg,et al.  IL-4 directs the development of Th2-like helper effectors. , 1990, Journal of immunology.

[106]  J. Rowley,et al.  Interleukin-4 and interleukin-5 map to human chromosome 5 in a region encoding growth factors and receptors and are deleted in myeloid leukemias with a del(5q). , 1989, Blood.

[107]  J. Stobo,et al.  Molecular events involved in regulating human interferon-gamma gene expression during T cell activation. , 1987, Journal of immunology.

[108]  R. Coffman,et al.  Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins. , 1986, Journal of immunology.

[109]  R. Atchison,et al.  Regulation of expression of the human interferon gamma gene. , 1985, Proceedings of the National Academy of Sciences of the United States of America.

[110]  W. Ouyang,et al.  Signaling and transcription in T helper development. , 2000, Annual review of immunology.

[111]  A Radbruch,et al.  Stat6-independent GATA-3 autoactivation directs IL-4-independent Th2 development and commitment. , 2000, Immunity.

[112]  S. Szabo,et al.  T helper differentiation proceeds through Stat1-dependent, Stat4-dependent and Stat4-independent phases. , 1999, Current topics in microbiology and immunology.

[113]  R. Flavell,et al.  CD40 and CD154 in cell-mediated immunity. , 1998, Annual review of immunology.

[114]  S. Constant,et al.  Induction of Th1 and Th2 CD4+ T cell responses: the alternative approaches. , 1997, Annual review of immunology.

[115]  H. Mcdevitt,et al.  Th1 and Th2 CD4+ T cells in the pathogenesis of organ-specific autoimmune diseases. , 1995, Immunology today.

[116]  G. Trinchieri.  Interleukin-12: a proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen-specific adaptive immunity. , 1995, Annual review of immunology.

[117]  S. Romagnani.  Lymphokine production by human T cells in disease states. , 1994, Annual review of immunology.

[118]  R. Coffman,et al.  Regulation of immunity to parasites by T cells and T cell-derived cytokines. , 1992, Annual review of immunology.