Interventions to prevent or reduce the level of frailty in community-dwelling older adults: a scoping review of the literature and international policies

Abstract Background frailty impacts older adults’ ability to recover from an acute illness, injuries and other stresses. Currently, a systematic synthesis of available interventions to prevent or reduce frailty does not exist. Therefore, we conducted a scoping review of interventions and international policies designed to prevent or reduce the level of frailty in community-dwelling older adults. Methods and analysis we conducted a scoping review using the framework of Arksey and O'Malley. We systematically searched articles and grey literature to identify interventions and policies that aimed to prevent or reduce the level of frailty. Results fourteen studies were included: 12 randomised controlled trials and 2 cohort studies (mean number of participants 260 (range 51–610)), with most research conducted in USA and Japan. The study quality was moderate to good. The interventions included physical activity; physical activity combined with nutrition; physical activity plus nutrition plus memory training; home modifications; prehabilitation (physical therapy plus exercise plus home modifications) and comprehensive geriatric assessment (CGA). Our review showed that the interventions that significantly reduced the number of frailty markers present or the prevalence of frailty included the physical activity interventions (all types and combinations), and prehabilitation. The CGA studies had mixed findings. Conclusion nine of the 14 studies reported that the intervention reduced the level of frailty. The results need to be interpreted with caution, as only 14 studies using 6 different definitions of frailty were retained. Future research could combine interventions targeting more frailty markers including cognitive or psychosocial well-being.

[1]  M. Andrew,et al.  Interventions to prevent or reduce the level of frailty in community-dwelling older adults: a protocol for a scoping review of the literature and international policies , 2016, BMJ Open.

[2]  E. Hoogendijk,et al.  Frailty measurement in research and clinical practice: A review. , 2016, European journal of internal medicine.

[3]  Maria Giné-Garriga,et al.  The effect of functional circuit training on physical frailty in frail older adults: a randomized controlled trial. , 2010, Journal of aging and physical activity.

[4]  B. Vellas White Book on Frailty , 2018 .

[5]  Minoru Yamada,et al.  Community-based exercise program is cost-effective by preventing care and disability in Japanese frail older adults. , 2012, Journal of the American Medical Directors Association.

[6]  Takao Suzuki,et al.  Effects of Exercise and Milk Fat Globule Membrane (MFGM) Supplementation on Body Composition, Physical Function, and Hematological Parameters in Community-Dwelling Frail Japanese Women: A Randomized Double Blind, Placebo-Controlled, Follow-Up Trial , 2015, PloS one.

[7]  C. Hsiung,et al.  A pilot randomized controlled trial to improve geriatric frailty , 2012, BMC Geriatrics.

[8]  Thomas M Gill,et al.  A prehabilitation program for physically frail community-living older persons. , 2003, Archives of physical medicine and rehabilitation.

[9]  Mari Carmen Gómez-Cabrera,et al.  A Multicomponent Exercise Intervention that Reverses Frailty and Improves Cognition, Emotion, and Social Networking in the Community-Dwelling Frail Elderly: A Randomized Clinical Trial. , 2016, Journal of the American Medical Directors Association.

[10]  H. Daudt,et al.  Enhancing the scoping study methodology: a large, inter-professional team’s experience with Arksey and O’Malley’s framework , 2013, BMC Medical Research Methodology.

[11]  Gill Turner,et al.  Best practice guidelines for the management of frailty: a British Geriatrics Society, Age UK and Royal College of General Practitioners report. , 2014, Age and ageing.

[12]  H. Boter,et al.  Prevalence of Frailty in Community‐Dwelling Older Persons: A Systematic Review , 2012, Journal of the American Geriatrics Society.

[13]  Shwu-chong Wu,et al.  The effectiveness of a comprehensive geriatric assessment intervention program for frailty in community-dwelling older people: a randomized, controlled trial. , 2010, Archives of gerontology and geriatrics.

[14]  E. Rothenberg,et al.  Health‐Promoting Interventions for Persons Aged 80 and Older Are Successful in the Short Term—Results from the Randomized and Three‐Armed Elderly Persons in the Risk Zone Study , 2012, Journal of the American Geriatrics Society.

[15]  S. Dahlin-Ivanoff,et al.  Health Promotion Can Postpone Frailty: Results from the RCT Elderly Persons in the Risk Zone. , 2016, Public health nursing.

[16]  Y. Yoshida,et al.  Effects of a combined physical training and nutrition intervention on physical performance and health-related quality of life in prefrail older women living in the community: a randomized controlled trial. , 2015, Journal of the American Medical Directors Association.

[17]  I. M. Lesende,et al.  El anciano frágil. Detección y tratamiento en AP , 2010 .

[18]  Matteo Cesari,et al.  Innovative Medicines Initiative: The SPRINTT Project. , 2015, The Journal of frailty & aging.

[19]  Kazuko Mitoku,et al.  Home modification and prevention of frailty progression in older adults: a Japanese prospective cohort study. , 2014, Journal of gerontological nursing.

[20]  T. Braun,et al.  Nutritional, Physical, Cognitive, and Combination Interventions and Frailty Reversal among Older Adults: A Randomized Controlled Trial , 2016, physioscience.

[21]  S. Lord,et al.  A multifactorial interdisciplinary intervention reduces frailty in older people: randomized trial , 2013, BMC Medicine.

[22]  Michael E. Miller,et al.  A physical activity intervention to treat the frailty syndrome in older persons-results from the LIFE-P study. , 2015, The journals of gerontology. Series A, Biological sciences and medical sciences.

[23]  H. Arksey,et al.  Scoping studies: towards a methodological framework , 2005 .

[24]  Karen Steger-May,et al.  Effects of Exercise Training on Frailty in Community‐Dwelling Older Adults: Results of a Randomized, Controlled Trial , 2002, Journal of the American Geriatrics Society.

[25]  D. Moher,et al.  Scoping reviews: time for clarity in definition, methods, and reporting. , 2014, Journal of clinical epidemiology.

[26]  European Scaling-up Strategy in Active and Healthy Ageing , 2014 .

[27]  P. Pluye,et al.  Systematic mixed studies reviews: updating results on the reliability and efficiency of the Mixed Methods Appraisal Tool. , 2015, International journal of nursing studies.

[28]  L. Fried,et al.  Frailty in older adults: evidence for a phenotype. , 2001, The journals of gerontology. Series A, Biological sciences and medical sciences.

[29]  D. Moher,et al.  Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. , 2010, International journal of surgery.