Myeloid-Derived Suppressor Cells Produce IL-10 to Elicit DNMT3b-Dependent IRF8 Silencing to Promote Colitis-Associated Colon Tumorigenesis

[1]  Yen-Hua Huang,et al.  Conceptual Development of Immunotherapeutic Approaches to Gastrointestinal Cancer , 2019, International journal of molecular sciences.

[2]  S. Gregory,et al.  Co-Operation between Aneuploidy and Metabolic Changes in Driving Tumorigenesis , 2019, International journal of molecular sciences.

[3]  Lingyun Wu,et al.  Tumor-Associated Neutrophils in Cancer: Going Pro , 2019, Cancers.

[4]  G. Neale,et al.  IRF8 Regulates Transcription of Naips for NLRC4 Inflammasome Activation , 2018, Cell.

[5]  N. Habermann,et al.  Robust prediction of gene regulation in colorectal cancer tissues from DNA methylation profiles , 2018, Epigenetics.

[6]  P. Wingfield,et al.  IL-12p35 induces expansion of IL-10 and IL-35-expressing regulatory B cells and ameliorates autoimmune disease , 2017, Nature Communications.

[7]  J. Shelton,et al.  NOD2 Suppresses Colorectal Tumorigenesis via Downregulation of the TLR Pathways. , 2017, Cell reports.

[8]  M. Colombo,et al.  Reciprocal influence of B cells and tumor macro and microenvironments in the ApcMin/+ model of colorectal cancer , 2017, Oncoimmunology.

[9]  Lori A. Coburn,et al.  EGFR-mediated Macrophage Activation Promotes Colitis-associated Tumorigenesis , 2017, Oncogene.

[10]  M. Diehn,et al.  Control of inflammation by stromal Hedgehog pathway activation restrains colitis , 2016, Proceedings of the National Academy of Sciences.

[11]  Hong-Min Kim,et al.  Interleukin-10 attenuates tumour growth by inhibiting interleukin-6/signal transducer and activator of transcription 3 signalling in myeloid-derived suppressor cells. , 2016, Cancer letters.

[12]  B. Amini,et al.  Thymidine phosphorylase exerts complex effects on bone resorption and formation in myeloma , 2016, Science Translational Medicine.

[13]  H. Tilg,et al.  Lipocalin 2 Protects from Inflammation and Tumorigenesis Associated with Gut Microbiota Alterations. , 2016, Cell host & microbe.

[14]  W. Leonard,et al.  Cutting Edge: Expression of IRF8 in Gastric Epithelial Cells Confers Protective Innate Immunity against Helicobacter pylori Infection , 2016, The Journal of Immunology.

[15]  Y. Ben-Neriah,et al.  Inflammatory networks underlying colorectal cancer , 2016, Nature Immunology.

[16]  V. Sanz-Moreno,et al.  Epigenetic switch drives the conversion of fibroblasts into proinvasive cancer-associated fibroblasts , 2015, Nature Communications.

[17]  Lin Sun,et al.  Dual Function of the IRF8 Transcription Factor in Autoimmune Uveitis: Loss of IRF8 in T Cells Exacerbates Uveitis, Whereas Irf8 Deletion in the Retina Confers Protection , 2015, The Journal of Immunology.

[18]  M. Takeda-Morishita,et al.  Protein tyrosine phosphatase SAP-1 protects against colitis through regulation of CEACAM20 in the intestinal epithelium , 2015, Proceedings of the National Academy of Sciences.

[19]  A. Star,et al.  MDSC and TGFβ Are Required for Facilitation of Tumor Growth in the Lungs of Mice Exposed to Carbon Nanotubes. , 2015, Cancer research.

[20]  C. Weaver,et al.  T-cell Expression of IL10 Is Essential for Tumor Immune Surveillance in the Small Intestine , 2015, Cancer Immunology Research.

[21]  C. Pucillo,et al.  Mast cell/MDSC a liaison immunosuppressive for tumor microenvironment , 2015, Oncoimmunology.

[22]  Hsien-Da Huang,et al.  MethHC: a database of DNA methylation and gene expression in human cancer , 2014, Nucleic Acids Res..

[23]  P. Sinha,et al.  Cross‐talk among myeloid‐derived suppressor cells, macrophages, and tumor cells impacts the inflammatory milieu of solid tumors , 2014, Journal of leukocyte biology.

[24]  Vivien W. Chan,et al.  Macrophage IL-10 blocks CD8+ T cell-dependent responses to chemotherapy by suppressing IL-12 expression in intratumoral dendritic cells. , 2014, Cancer cell.

[25]  M. Colombo,et al.  Mast Cells Boost Myeloid-Derived Suppressor Cell Activity and Contribute to the Development of Tumor-Favoring Microenvironment , 2014, Cancer Immunology Research.

[26]  Donald Metcalf,et al.  A Reporter Mouse Reveals Lineage-Specific and Heterogeneous Expression of IRF8 during Lymphoid and Myeloid Cell Differentiation , 2014, The Journal of Immunology.

[27]  M. Oft IL-10: Master Switch from Tumor-Promoting Inflammation to Antitumor Immunity , 2014, Cancer Immunology Research.

[28]  S. Dey,et al.  CXCR2-expressing myeloid-derived suppressor cells are essential to promote colitis-associated tumorigenesis. , 2013, Cancer cell.

[29]  Gregory M. Frank,et al.  STAT3 Regulates Proliferation and Survival of CD8+ T Cells: Enhances Effector Responses to HSV-1 Infection, and Inhibits IL-10+ Regulatory CD8+ T Cells in Autoimmune Uveitis , 2013, Mediators of inflammation.

[30]  D. Swallow,et al.  Refinement in localization and identification of gene regions associated with Crohn disease. , 2013, American journal of human genetics.

[31]  David C. Wilson,et al.  Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease , 2012, Nature.

[32]  E. Kuipers,et al.  IL-6-induced DNMT1 activity mediates SOCS3 promoter hypermethylation in ulcerative colitis-related colorectal cancer. , 2012, Carcinogenesis.

[33]  Grace Y Chen,et al.  Interleukin-10 ablation promotes tumor development, growth, and metastasis. , 2012, Cancer research.

[34]  T. Mcclanahan,et al.  IL-10 elicits IFNγ-dependent tumor immune surveillance. , 2011, Cancer cell.

[35]  Chen-feng Qi,et al.  IFN Regulatory Factor 8 Restricts the Size of the Marginal Zone and Follicular B Cell Pools , 2011, The Journal of Immunology.

[36]  J. Prieto,et al.  Oxaliplatin in combination with liver-specific expression of interleukin 12 reduces the immunosuppressive microenvironment of tumours and eradicates metastatic colorectal cancer in mice , 2010, Gut.

[37]  Shuang Huang,et al.  DNA Methylation Represses IFN-γ–Induced and Signal Transducer and Activator of Transcription 1–Mediated IFN Regulatory Factor 8 Activation in Colon Carcinoma Cells , 2008, Molecular Cancer Research.

[38]  Judy H. Cho,et al.  Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease , 2008, Nature Genetics.

[39]  P. Laird,et al.  CpG island methylator phenotype underlies sporadic microsatellite instability and is tightly associated with BRAF mutation in colorectal cancer , 2006, Nature Genetics.

[40]  Michael Karin,et al.  IKKβ Links Inflammation and Tumorigenesis in a Mouse Model of Colitis-Associated Cancer , 2004, Cell.

[41]  Bert Vogelstein,et al.  DNMT1 and DNMT3b cooperate to silence genes in human cancer cells , 2002, Nature.

[42]  R. Coffman,et al.  Interleukin-10 and the interleukin-10 receptor. , 2001, Annual review of immunology.

[43]  J. McKinzie,et al.  Induction of the apoptosis-promoting protein Bak by perillyl alcohol in pancreatic ductal adenocarcinoma relative to untransformed ductal epithelial cells. , 1997, Carcinogenesis.

[44]  J. Waring,et al.  Immunodeficiency and Chronic Myelogenous Leukemia-like Syndrome in Mice with a Targeted Mutation of the ICSBP Gene , 1996, Cell.