论文信息 - COX-2's new role in inflammation.

COX-2's new role in inflammation.

COX-2 is the enzyme largely responsible for causing inflammation, a common mechanism of disease. A study now reports that derivatives generated by COX-2 from naturally occurring ω-3 fatty acids are anti-inflammatory mediators.

Chu Chen | Chu Chen

[1] C. Serhan,et al. Resolvin D1 binds human phagocytes with evidence for proresolving receptors , 2010, Proceedings of the National Academy of Sciences.

[2] C. Serhan,et al. Resolvins , 2002, The Journal of experimental medicine.

[3] Song‐Pyo Hong,et al. Novel Docosanoids Inhibit Brain Ischemia-Reperfusion-mediated Leukocyte Infiltration and Pro-inflammatory Gene Expression* , 2003, Journal of Biological Chemistry.

[4] D. Gilroy,et al. Inducible cyclooxygenase may have anti-inflammatory properties , 1999, Nature Medicine.

[5] T. Montine,et al. Electrophilic Cyclopentenone Neuroprostanes Are Anti-inflammatory Mediators Formed from the Peroxidation of the ω-3 Polyunsaturated Fatty Acid Docosahexaenoic Acid* , 2008, Journal of Biological Chemistry.

[6] C. Serhan,et al. Anti-inflammatory and proresolving lipid mediators. , 2008, Annual review of pathology.

[7] Charles N. Serhan,et al. Resolvin E1 and protectin D1 activate inflammation-resolution programmes , 2007, Nature.

[8] M. P. Cole,et al. Cyclooxygenase-2 generates anti-inflammatory mediators from omega-3 fatty acids. , 2010, Nature chemical biology.

[9] C. Serhan,et al. Endogenous pro‐resolving and anti‐inflammatory lipid mediators: a new pharmacologic genus , 2008, British journal of pharmacology.