The potentiometric titration of aminophylline and aminophylline-phenobarbital mixtures.
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The literature is briefly reviewed for methods of determining aminophylline, theophylline, and phenobarbital individually and in combinations with each other. Procedures are presented for potentiometrically titrating phenobarbital, theophylline, and aminophylline; combinations of phenobarbital with either aminophylline or theophylline. Typical titration curves are presented, and the data from several titrations are tabulated. The results obtained by titrating aminophylline potentiometrically are shown to compare favorably with those obtained by the U. S. P. method. The results obtained by potentiometrically titrating mixtures of theophylline and phenobarbital were found to be compatible with the known amounts of these substances present.