Lung Adenocarcinoma Distally Rewires Hepatic Circadian Homeostasis

[1]  R. Medzhitov,et al.  The Effect of Sustained Inflammation on Hepatic Mevalonate Pathway Results in Hyperglycemia , 2016, Cell.

[2]  Paolo Sassone-Corsi,et al.  Time for Food: The Intimate Interplay between Nutrition, Metabolism, and the Circadian Clock , 2015, Cell.

[3]  J. Durstine,et al.  Liver Inflammation and Metabolic Signaling in ApcMin/+ Mice: The Role of Cachexia Progression , 2015, PloS one.

[4]  J. Mauer,et al.  Versatile functions for IL-6 in metabolism and cancer. , 2015, Trends in immunology.

[5]  P. Sassone-Corsi,et al.  Circadian clocks, epigenetics, and cancer , 2015, Current opinion in oncology.

[6]  Hua Yu,et al.  Revisiting STAT3 signalling in cancer: new and unexpected biological functions , 2014, Nature Reviews Cancer.

[7]  G. Cline,et al.  Functional polarization of tumour-associated macrophages by tumour-derived lactic acid , 2014, Nature.

[8]  M. Pichler,et al.  Corrigendum to “Tumor Macroenvironment and Metabolism” [Seminars in Oncology, Vol 41, No 2, April 2014, pp 281–295] , 2014, Seminars in oncology.

[9]  K. Gamble,et al.  Circadian clock control of endocrine factors , 2014, Nature Reviews Endocrinology.

[10]  Pierre Baldi,et al.  Partitioning Circadian Transcription by SIRT6 Leads to Segregated Control of Cellular Metabolism , 2014, Cell.

[11]  M. Pichler,et al.  Tumor Macroenvironment and Metabolism , 2014, Seminars in oncology.

[12]  R. Zechner,et al.  Depletion of White Adipose Tissue in Cancer Cachexia Syndrome Is Associated with Inflammatory Signaling and Disrupted Circadian Regulation , 2014, PloS one.

[13]  N. Guex,et al.  Genome-Wide Analysis of SREBP1 Activity around the Clock Reveals Its Combined Dependency on Nutrient and Circadian Signals , 2014, PLoS genetics.

[14]  J. Takahashi,et al.  Molecular architecture of the mammalian circadian clock. , 2014, Trends in cell biology.

[15]  Pierre Baldi,et al.  Reprogramming of the Circadian Clock by Nutritional Challenge , 2013, Cell.

[16]  John L Cleveland,et al.  Targeting lactate metabolism for cancer therapeutics. , 2013, Journal of Clinical Investigation.

[17]  J. Bass,et al.  Circadian topology of metabolism , 2012, Nature.

[18]  Satchidananda Panda,et al.  Time-restricted feeding without reducing caloric intake prevents metabolic diseases in mice fed a high-fat diet. , 2012, Cell metabolism.

[19]  L. Cantley,et al.  Cancer Cell Metabolism , 2012 .

[20]  A. Loudon,et al.  The nuclear receptor REV-ERBα mediates circadian regulation of innate immunity through selective regulation of inflammatory cytokines , 2011, Proceedings of the National Academy of Sciences.

[21]  B. Gao,et al.  Inflammation‐associated interleukin‐6/signal transducer and activator of transcription 3 activation ameliorates alcoholic and nonalcoholic fatty liver diseases in interleukin‐10–deficient mice , 2011, Hepatology.

[22]  T. Zimmers,et al.  STAT3 Activation in Skeletal Muscle Links Muscle Wasting and the Acute Phase Response in Cancer Cachexia , 2011, PloS one.

[23]  H. Pilegaard,et al.  Interleukin‐6 modifies mRNA expression in mouse skeletal muscle , 2011, Acta physiologica.

[24]  Z. Varghese,et al.  Inflammatory stress exacerbates hepatic cholesterol accumulation via increasing cholesterol uptake and de novo synthesis , 2011, Journal of gastroenterology and hepatology.

[25]  Shizuo Akira,et al.  Stat3/Socs3 activation by IL-6 transsignaling promotes progression of pancreatic intraepithelial neoplasia and development of pancreatic cancer. , 2011, Cancer cell.

[26]  Mengwei Zang,et al.  AMPK phosphorylates and inhibits SREBP activity to attenuate hepatic steatosis and atherosclerosis in diet-induced insulin-resistant mice. , 2011, Cell metabolism.

[27]  D. Hanahan,et al.  Hallmarks of Cancer: The Next Generation , 2011, Cell.

[28]  Sofianos Andrikopoulos,et al.  Liver‐specific suppressor of cytokine signaling‐3 deletion in mice enhances hepatic insulin sensitivity and lipogenesis resulting in fatty liver and obesity 1 , 2010, Hepatology.

[29]  Paolo Sassone-Corsi,et al.  Plasticity and specificity of the circadian epigenome , 2010, Nature Neuroscience.

[30]  Dmitri A. Nusinow,et al.  Cryptochrome Mediates Circadian Regulation of cAMP Signaling and Hepatic Gluconeogenesis , 2010, Nature Medicine.

[31]  T. Okanoue,et al.  Blockade of interleukin-6 signaling enhances hepatic steatosis but improves liver injury in methionine choline-deficient diet-fed mice , 2010, Laboratory Investigation.

[32]  M. Karin,et al.  Immunity, Inflammation, and Cancer , 2010, Cell.

[33]  S. Panda,et al.  Time of feeding and the intrinsic circadian clock drive rhythms in hepatic gene expression , 2009, Proceedings of the National Academy of Sciences.

[34]  Paolo Sassone-Corsi,et al.  Metabolism and cancer: the circadian clock connection , 2009, Nature Reviews Cancer.

[35]  Ueli Schibler,et al.  REV-ERBα Participates in Circadian SREBP Signaling and Bile Acid Homeostasis , 2009, PLoS biology.

[36]  Corey D. DeHaven,et al.  Integrated, nontargeted ultrahigh performance liquid chromatography/electrospray ionization tandem mass spectrometry platform for the identification and relative quantification of the small-molecule complement of biological systems. , 2009, Analytical chemistry.

[37]  L. Cantley,et al.  Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation , 2009, Science.

[38]  M. Karin,et al.  IL-6 and Stat3 are required for survival of intestinal epithelial cells and development of colitis-associated cancer. , 2009, Cancer cell.

[39]  D. Sabatini,et al.  Cancer Cell Metabolism: Warburg and Beyond , 2008, Cell.

[40]  Z. Varghese,et al.  Inflammatory stress exacerbates lipid accumulation in hepatic cells and fatty livers of apolipoprotein E knockout mice , 2008, Hepatology.

[41]  W. Gerald,et al.  Mutations in the EGFR kinase domain mediate STAT3 activation via IL-6 production in human lung adenocarcinomas. , 2007, The Journal of clinical investigation.

[42]  D. Santini,et al.  IL-6 triggers malignant features in mammospheres from human ductal breast carcinoma and normal mammary gland. , 2007, The Journal of clinical investigation.

[43]  Kathryn Moynihan Ramsey,et al.  High-fat diet disrupts behavioral and molecular circadian rhythms in mice. , 2007, Cell metabolism.

[44]  Wan-Wan Lin,et al.  A cytokine-mediated link between innate immunity, inflammation, and cancer. , 2007, The Journal of clinical investigation.

[45]  A. Yoshimura,et al.  The dual function of hepatic SOCS3 in insulin resistance in vivo , 2007, Genes to cells : devoted to molecular & cellular mechanisms.

[46]  B. Pedersen,et al.  Interleukin-6 Regulation of AMP-Activated Protein Kinase , 2006, Diabetes.

[47]  D. James,et al.  Interleukin-6 Increases Insulin-Stimulated Glucose Disposal in Humans and Glucose Uptake and Fatty Acid Oxidation In Vitro via AMP-Activated Protein Kinase , 2006, Diabetes.

[48]  Helen H. W. Chen,et al.  Autocrine IL-6-induced Stat3 activation contributes to the pathogenesis of lung adenocarcinoma and malignant pleural effusion , 2006, Oncogene.

[49]  T. Jacks,et al.  The differential effects of mutant p53 alleles on advanced murine lung cancer. , 2005, Cancer research.

[50]  U. Markert,et al.  Leukemia inhibitory factor triggers activation of signal transducer and activator of transcription 3, proliferation, invasiveness, and altered protease expression in choriocarcinoma cells. , 2005, The international journal of biochemistry & cell biology.

[51]  B. Pedersen,et al.  AMPK activity is diminished in tissues of IL-6 knockout mice: the effect of exercise. , 2004, Biochemical and biophysical research communications.

[52]  K. Syrigos,et al.  Serum levels of IL-6 and TNF-α correlate with clinicopathological features and patient survival in patients with prostate cancer , 2004, British Journal of Cancer.

[53]  Jay D. Horton,et al.  Combined analysis of oligonucleotide microarray data from transgenic and knockout mice identifies direct SREBP target genes , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[54]  L. Fu,et al.  The circadian clock: pacemaker and tumour suppressor , 2003, Nature Reviews Cancer.

[55]  T. Zimmers,et al.  Suppressor of Cytokine Signaling-3 (SOCS-3), a Potential Mediator of Interleukin-6-dependent Insulin Resistance in Hepatocytes* , 2003, The Journal of Biological Chemistry.

[56]  M. White,et al.  SOCS-1 and SOCS-3 Block Insulin Signaling by Ubiquitin-mediated Degradation of IRS1 and IRS2* , 2002, The Journal of Biological Chemistry.

[57]  B. H. Miller,et al.  Coordinated Transcription of Key Pathways in the Mouse by the Circadian Clock , 2002, Cell.

[58]  T. Jacks,et al.  Analysis of lung tumor initiation and progression using conditional expression of oncogenic K-ras. , 2001, Genes & development.

[59]  E. Van Obberghen,et al.  SOCS-3 Inhibits Insulin Signaling and Is Up-regulated in Response to Tumor Necrosis Factor-α in the Adipose Tissue of Obese Mice* , 2001, The Journal of Biological Chemistry.

[60]  J. Miyazaki,et al.  Tissue-Specific Autoregulation of thestat3 Gene and Its Role in Interleukin-6-Induced Survival Signals in T Cells , 2001, Molecular and Cellular Biology.

[61]  T. Jacks,et al.  Somatic activation of the K-ras oncogene causes early onset lung cancer in mice , 2001, Nature.

[62]  Y Sakaki,et al.  Entrainment of the circadian clock in the liver by feeding. , 2001, Science.

[63]  F. Fleury-Olela,et al.  Restricted feeding uncouples circadian oscillators in peripheral tissues from the central pacemaker in the suprachiasmatic nucleus. , 2000, Genes & development.

[64]  L. Pfeffer,et al.  Induction of Jak/STAT signaling by activation of the type 1 TNF receptor. , 1998, Journal of immunology.

[65]  J. Darnell.  STATs and gene regulation. , 1997, Science.

[66]  B. Kemp,et al.  Contraction-induced Changes in Acetyl-CoA Carboxylase and 5′-AMP-activated Kinase in Skeletal Muscle* , 1997, The Journal of Biological Chemistry.

[67]  J. Goldstein,et al.  The SREBP Pathway: Regulation of Cholesterol Metabolism by Proteolysis of a Membrane-Bound Transcription Factor , 1997, Cell.

[68]  J. Darnell,et al.  Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins. , 1994, Science.