Peripheral brain-derived neurotrophic factor (BDNF) as a biomarker in bipolar disorder: a meta-analysis of 52 studies

[1]  M. Vinberg,et al.  Peripheral blood brain-derived neurotrophic factor in bipolar disorder: a comprehensive systematic review and meta-analysis , 2016, Molecular Psychiatry.

[2]  M. Thase,et al.  Peripheral vascular endothelial growth factor as a novel depression biomarker: A meta-analysis , 2015, Psychoneuroendocrinology.

[3]  M. Berk,et al.  Increased serum levels of eotaxin/CCL11 in late-stage patients with bipolar disorder: An accelerated aging biomarker? , 2015, Journal of affective disorders.

[4]  K. Wittfeld,et al.  Neuroscience and Biobehavioral Reviews Review Bdnf Val66met Polymorphism and Hippocampal Volume in Neuropsychiatric Disorders: a Systematic Review and Meta-analysis , 2022 .

[5]  M. Vinberg,et al.  A composite peripheral blood gene expression measure as a potential diagnostic biomarker in bipolar disorder , 2015, Translational Psychiatry.

[6]  M. Berk,et al.  C-reactive protein is increased in schizophrenia but is not altered by antipsychotics: meta-analysis and implications , 2015, Molecular Psychiatry.

[7]  E. Vieta Staging and psychosocial early intervention in bipolar disorder. , 2015, The lancet. Psychiatry.

[8]  M. Emul,et al.  Plasma BDNFs level initially and post treatment in acute mania: comparison between ECT and atypical antipsychotic treatment and healthy controls , 2015, Journal of psychopharmacology.

[9]  P. Schoenknecht,et al.  BDNF as a biomarker for successful treatment of mood disorders: a systematic & quantitative meta-analysis. , 2015, Journal of affective disorders.

[10]  J. Ioannidis,et al.  Environmental risk factors and multiple sclerosis: an umbrella review of systematic reviews and meta-analyses , 2015, The Lancet Neurology.

[11]  H. Nicolini,et al.  The role of brain‐derived neurotrophic factor (BDNF) Val66Met genetic polymorphism in bipolar disorder: a case–control study, comorbidities, and meta‐analysis of 16,786 subjects , 2015, Bipolar disorders.

[12]  R. Lu,et al.  Correlation of plasma brain‐derived neurotrophic factor and metabolic profiles in drug‐naïve patients with bipolar II disorder after a twelve‐week pharmacological intervention , 2015, Acta psychiatrica Scandinavica.

[13]  A. Özerdem,et al.  Diverse Glial Cell Line-Derived Neurotrophic Factor (GDNF) Support Between Mania and Schizophrenia: A Comparative Study in Four Major Psychiatric Disorders , 2015, European Psychiatry.

[14]  H. Akiskal,et al.  Decreased plasma levels of brain-derived neurotrophic factor (BDNF) during mixed episodes of bipolar disorder. , 2015, Journal of affective disorders.

[15]  M. Leboyer,et al.  Staging systems in bipolar disorder: an International Society for Bipolar Disorders Task Force Report , 2014, Acta psychiatrica Scandinavica.

[16]  M. Maes,et al.  Towards a classification of biomarkers of neuropsychiatric disease: from encompass to compass , 2014, Molecular Psychiatry.

[17]  M. Berk,et al.  Peripheral brain-derived neurotrophic factor in schizophrenia and the role of antipsychotics: meta-analysis and implications , 2014, Molecular Psychiatry.

[18]  G. Ergör,et al.  Alterations in BDNF (brain derived neurotrophic factor) and GDNF (glial cell line-derived neurotrophic factor) serum levels in bipolar disorder: The role of lithium. , 2014, Journal of affective disorders.

[19]  M. Vinberg,et al.  Elevated levels of plasma brain derived neurotrophic factor in rapid cycling bipolar disorder patients , 2014, Psychoneuroendocrinology.

[20]  B. Penninx,et al.  Chronic depression is associated with a pronounced decrease in serum brain-derived neurotrophic factor over time , 2014, Molecular Psychiatry.

[21]  M. Berk,et al.  Stage managing bipolar disorder , 2014, Bipolar disorders.

[22]  B. Penninx,et al.  Serum BDNF concentrations as peripheral manifestations of depression: evidence from a systematic review and meta-analyses on 179 associations (N=9484) , 2014, Molecular Psychiatry.

[23]  Zhiguo Wu,et al.  Brain-derived neurotrophic factor levels and bipolar disorder in patients in their first depressive episode: 3-year prospective longitudinal study. , 2014, The British journal of psychiatry : the journal of mental science.

[24]  M. Berk,et al.  Decreased peripheral brain-derived neurotrophic factor levels are a biomarker of disease activity in major psychiatric disorders: a comparative meta-analysis , 2014, Molecular Psychiatry.

[25]  Y. Okubo,et al.  The Noradrenaline Metabolite MHPG Is a Candidate Biomarker from the Manic to the Remission State in Bipolar Disorder I: A Clinical Naturalistic Study , 2014, PloS one.

[26]  M. Rabie,et al.  Serum level of brain derived neurotrophic factor (BDNF) among patients with bipolar disorder. , 2014, Journal of affective disorders.

[27]  P. Chen,et al.  The BDNF Val66Met polymorphism and plasma brain-derived neurotrophic factor levels in Han Chinese patients with bipolar disorder and schizophrenia , 2014, Progress in Neuro-Psychopharmacology and Biological Psychiatry.

[28]  M. Butters,et al.  The relationship between interleukin‐1 receptor antagonist and cognitive function in older adults with bipolar disorder , 2014, International journal of geriatric psychiatry.

[29]  B. Frey,et al.  Val66Met polymorphism and serum brain‐derived neurotrophic factor in bipolar disorder: an open‐label trial , 2014, Acta psychiatrica Scandinavica.

[30]  K. Hashimoto,et al.  Abnormality in serum levels of mature brain-derived neurotrophic factor (BDNF) and its precursor proBDNF in mood-stabilized patients with bipolar disorder: a study of two independent cohorts. , 2014, Journal of affective disorders.

[31]  H. Kenna,et al.  Blood levels of brain derived neurotrophic factor in women with bipolar disorder and healthy control women. , 2014, Journal of affective disorders.

[32]  B. Mulsant,et al.  Decrease Brain-Derived Neurotrophic Factor (BDNF) in Older Patients with Bipolar Disorder , 2014 .

[33]  G. Goodwin,et al.  Altered plasma glutathione levels in bipolar disorder indicates higher oxidative stress; a possible risk factor for illness onset despite normal brain-derived neurotrophic factor (BDNF) levels , 2014, Psychological Medicine.

[34]  Yong-Ku Kim,et al.  High insulin-like growth factor-1 in patients with bipolar I disorder: a trait marker? , 2013, Journal of affective disorders.

[35]  M. P. Fleck,et al.  P.2.c.012 Evaluation of peripheral biomarkers in bipolar and unipolar depression , 2013, European Neuropsychopharmacology.

[36]  C. Gamble,et al.  Systematic Review of the Empirical Evidence of Study Publication Bias and Outcome Reporting Bias — An Updated Review , 2013, PloS one.

[37]  M. Leboyer,et al.  Biomarkers in bipolar disorder: A positional paper from the International Society for Bipolar Disorders Biomarkers Task Force , 2013, The Australian and New Zealand journal of psychiatry.

[38]  A. Teixeira,et al.  Increased BDNF levels in long-term bipolar disorder patients. , 2013, Revista brasileira de psiquiatria.

[39]  J. Rybakowski,et al.  Single ketamine infusion in bipolar depression resistant to antidepressants: are neurotrophins involved? , 2013, Human psychopharmacology.

[40]  Shyh-Jen Wang,et al.  Impaired cognition in bipolar I disorder: the roles of the serotonin transporter and brain-derived neurotrophic factor. , 2012, Journal of affective disorders.

[41]  B. Frey,et al.  Peripheral brain-derived neurotrophic factor changes along treatment with extended release quetiapine during acute mood episodes: an open-label trial in drug-free patients with bipolar disorder. , 2012, Journal of psychiatric research.

[42]  M. Frye,et al.  The clinical management of bipolar disorder complexity using a stratified model , 2012, Bipolar disorders.

[43]  James J. Choi,et al.  Activation of signaling pathways following localized delivery of systemically administered neurotrophic factors across the blood–brain barrier using focused ultrasound and microbubbles , 2012, Physics in medicine and biology.

[44]  E. Vieta,et al.  One‐year psychosocial functioning in patients in the early vs. late stage of bipolar disorder , 2012, Acta psychiatrica Scandinavica.

[45]  C. Pariante,et al.  Executive dysfunction in euthymic bipolar disorder patients and its association with plasma biomarkers. , 2012, Journal of affective disorders.

[46]  Chien-Te Lee,et al.  Serum Protein Levels of Brain-Derived Neurotrophic Factor and Tropomyosin-Related Kinase B in Bipolar Disorder: Effects of Mood Stabilizers , 2012, Neuropsychobiology.

[47]  Y. Hung,et al.  Brain-Derived Neurotrophic Factor, Adiponectin, and Proinflammatory Markers in Various Subtypes of Depression in Young Men , 2011, International journal of psychiatry in medicine.

[48]  F. Kapczinski,et al.  Brain-derived neurotrophic factor as a state-marker of mood episodes in bipolar disorders: a systematic review and meta-regression analysis. , 2011, Journal of psychiatric research.

[49]  O. Forlenza,et al.  Lithium increases plasma brain-derived neurotrophic factor in acute bipolar mania: A preliminary 4-week study , 2011, Neuroscience Letters.

[50]  G. Knudsen,et al.  Blood BDNF concentrations reflect brain-tissue BDNF levels across species. , 2011, The international journal of neuropsychopharmacology.

[51]  Flávio Kapczinski,et al.  Peripheral biomarkers and illness activity in bipolar disorder. , 2011, Journal of psychiatric research.

[52]  M. Berk,et al.  eview athways underlying neuroprogression in bipolar disorder : Focus on nflammation , oxidative stress and neurotrophic factors , 2010 .

[53]  J. Rybakowski,et al.  Serum Brain-Derived Neurotrophic Factor in Euthymic Bipolar Patients on Prophylactic Lithium Therapy , 2010, Neuropsychobiology.

[54]  Michele Tarsilla Cochrane Handbook for Systematic Reviews of Interventions , 2010, Journal of MultiDisciplinary Evaluation.

[55]  A. Piccini,et al.  Plasma brain-derived neurotrophic factor in bipolar and unipolar depression , 2010 .

[56]  N. Siafakas,et al.  Association of Serum Brain-Derived Neurotrophic Factor and Duration of Untreated Psychosis in First-Episode Patients with Schizophrenia , 2010, Neuropsychobiology.

[57]  J. Rybakowski,et al.  Excellent lithium responders have normal cognitive functions and plasma BDNF levels. , 2010, The international journal of neuropsychopharmacology.

[58]  Z. Janka,et al.  Increased plasma levels of brain-derived neurotrophic factor in patients with long-term bipolar disorder , 2010, Neuroscience Letters.

[59]  H. Nasrallah,et al.  Decreased BDNF levels in CSF of drug-naive first-episode psychotic subjects: correlation with plasma BDNF and psychopathology. , 2010, The international journal of neuropsychopharmacology.

[60]  R. Yoshimura,et al.  Adding a low dose atypical antipsychotic drug to an antidepressant induced a rapid increase of plasma brain-derived neurotrophic factor levels in patients with treatment-resistant depression , 2010, Progress in Neuro-Psychopharmacology and Biological Psychiatry.

[61]  C. Reid,et al.  Cocaine-mediated synaptic potentiation is absent in VTA neurons from mGlu5-deficient mice. , 2010, The international journal of neuropsychopharmacology.

[62]  Pao-Yen Lin State-dependent decrease in levels of brain-derived neurotrophic factor in bipolar disorder: A meta-analytic study , 2009, Neuroscience Letters.

[63]  M. Berk,et al.  The concept of staging in bipolar disorder: the role of BDNF and TNF-alpha as biomarkers , 2009, Acta Neuropsychiatrica.

[64]  E. Erdfelder,et al.  Statistical power analyses using G*Power 3.1: Tests for correlation and regression analyses , 2009, Behavior research methods.

[65]  F. Kapczinski,et al.  Serum brain-derived neurotrophic factor in bipolar and unipolar depression: a potential adjunctive tool for differential diagnosis. , 2009, Journal of psychiatric research.

[66]  B. Frey,et al.  Cognitive function and serum levels of brain-derived neurotrophic factor in patients with bipolar disorder. , 2009, Bipolar disorders.

[67]  F. Kapczinski,et al.  Decreased brain-derived neurotrophic factor in medicated and drug-free bipolar patients. , 2009, Journal of psychiatric research.

[68]  J. Kelly,et al.  Serum BDNF levels in euthymic bipolar disorder: preliminary results from the Galway Bipolar Study , 2009 .

[69]  R. Lam,et al.  Brain-derived neurotrophic factor and inflammatory markers in patients with early- vs. late-stage bipolar disorder. , 2009, The international journal of neuropsychopharmacology.

[70]  F. Kapczinski,et al.  Brain-derived neurotrophic factor serum levels before and after treatment for acute mania , 2009, Neuroscience Letters.

[71]  F J McMahon,et al.  Convergent functional genomics of genome‐wide association data for bipolar disorder: Comprehensive identification of candidate genes, pathways and mechanisms , 2009, American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics.

[72]  David J Spiegelhalter,et al.  A re-evaluation of random-effects meta-analysis , 2009, Journal of the Royal Statistical Society. Series A,.

[73]  Julian P T Higgins,et al.  Commentary: Heterogeneity in meta-analysis should be expected and appropriately quantified. , 2008, International journal of epidemiology.

[74]  M. Maj,et al.  Decreased levels of serum brain-derived neurotrophic factor in both depressed and euthymic patients with unipolar depression and in euthymic patients with bipolar I and II disorders. , 2008, Bipolar disorders.

[75]  M. Esler,et al.  Reduced overflow of BDNF from the brain is linked with suicide risk in depressive illness , 2007, Molecular Psychiatry.

[76]  J. Ioannidis,et al.  An exploratory test for an excess of significant findings , 2007, Clinical trials.

[77]  A. Young,et al.  Changes in Brain-Derived Neurotrophic Factor Following Treatment with Mifepristone in Bipolar Disorder and Schizophrenia , 2007, The Australian and New Zealand journal of psychiatry.

[78]  B. Frey,et al.  Val66met polymorphism and serum brain-derived neurotrophic factor levels in bipolar disorder , 2007, Molecular Psychiatry.

[79]  M. Dietrich,et al.  Decreased Plasma Brain Derived Neurotrophic Factor Levels in Unmedicated Bipolar Patients During Manic Episode , 2007, Biological Psychiatry.

[80]  R. Yoshimura,et al.  Effect of risperidone on plasma catecholamine metabolites and brain‐derived neurotrophic factor in patients with bipolar disorders , 2006, Human psychopharmacology.

[81]  F. Mosquera,et al.  Decreased levels of plasma BDNF in first-episode schizophrenia and bipolar disorder patients , 2006, Schizophrenia Research.

[82]  Tania B. Huedo-Medina,et al.  Assessing heterogeneity in meta-analysis: Q statistic or I2 index? , 2006, Psychological methods.

[83]  B. Frey,et al.  Serum brain-derived neurotrophic factor is decreased in bipolar disorder during depressive and manic episodes , 2006, Neuroscience Letters.

[84]  S. Young,et al.  The File-Drawer Problem, Revisited , 2004, Science.

[85]  D. Altman,et al.  Measuring inconsistency in meta-analyses , 2003, BMJ : British Medical Journal.

[86]  M. Schwald,et al.  Postnatal developmental profile of brain-derived neurotrophic factor in rat brain and platelets , 2002, Neuroscience Letters.

[87]  H. Nawa,et al.  Decreased levels of brain-derived neurotrophic factor in serum of chronic schizophrenic patients , 2002, Psychiatry Research.

[88]  S. Thompson,et al.  Quantifying heterogeneity in a meta‐analysis , 2002, Statistics in medicine.

[89]  Ruoyan Chen,et al.  Brain-derived Neurotrophic Factor Is Stored in Human Platelets and Released by Agonist Stimulation , 2002, Thrombosis and Haemostasis.

[90]  J. Aubry,et al.  Decreased serum brain-derived neurotrophic factor levels in major depressed patients , 2002, Psychiatry Research.

[91]  P. Mergo,et al.  A simple method for obtaining original data from published graphs and plots. , 2000, AJR. American journal of roentgenology.

[92]  I. Olkin,et al.  Meta-analysis of observational studies in epidemiology - A proposal for reporting , 2000 .

[93]  William A Banks,et al.  Transport of brain-derived neurotrophic factor across the blood–brain barrier , 1998, Neuropharmacology.

[94]  J P Vandenbroucke,et al.  Bias in meta-analysis detected by a simple, graphical test , 1998 .

[95]  J. Ioannidis,et al.  Quantitative Synthesis in Systematic Reviews , 1997, Annals of Internal Medicine.

[96]  G. Smith,et al.  Bias in meta-analysis detected by a simple, graphical test , 1997, BMJ.

[97]  E. Nestler,et al.  A molecular and cellular theory of depression. , 1997, Archives of general psychiatry.

[98]  H. Thoenen,et al.  Purification of a new neurotrophic factor from mammalian brain. , 1982, The EMBO journal.

[99]  T. Kuhn,et al.  The Structure of Scientific Revolutions. , 1964 .

[100]  M. Hamilton A RATING SCALE FOR DEPRESSION , 1960, Journal of neurology, neurosurgery, and psychiatry.

[101]  V. Hamburger,et al.  Selective growth stimulating effects of mouse sarcoma on the sensory and sympathetic nervous system of the chick embryo. , 1951, The Journal of experimental zoology.

[102]  R. Kupka,et al.  Staging systems in bipolar disorder , 2015 .

[103]  J. Higgins,et al.  Cochrane Handbook for Systematic Reviews of Interventions, Version 5.1.0. The Cochrane Collaboration , 2013 .

[104]  Fang Yi-ru Changes of plasma brain-derived neurotrophic factor in patients with bipolar disorder type I , 2011 .

[105]  J. Higgins Cochrane handbook for systematic reviews of interventions. Version 5.1.0 [updated March 2011]. The Cochrane Collaboration , 2011 .

[106]  F. Kapczinski,et al.  Brain-derived neurotrophic factor as a possible biomarker of bipolar disorder activity , 2010 .

[107]  D. Moher,et al.  Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. , 2010, International journal of surgery.

[108]  I. Olkin,et al.  Meta-analysis of observational studies in epidemiology: a proposal for reporting. Meta-analysis Of Observational Studies in Epidemiology (MOOSE) group. , 2000, JAMA.

[109]  T. Kuhn The structure of scientific revolutions, 3rd ed. , 1996 .