Effect of Action Potential Duration and Conduction Velocity Restitution and Their Spatial Dispersion on Alternans and the Stability of Arrhythmias

Restitution and Spatial Heterogeneities vs Arrhythmias. Introduction: The slope of the action potential duration (APD) restitution curve has been used to explain wavebreaks during arrhythmia initiation and maintenance. This hypothesis remains incomplete to fully describe the experimental data. Other factors contributing to wavebreaks must be studied to further understand arrhythmia dynamics.

[1]  M Manoach,et al.  Ventricular self-defibrillation in mammals: age and drug dependence. , 1980, Age and ageing.

[2]  A. Garfinkel,et al.  Chaos and the transition to ventricular fibrillation: a new approach to antiarrhythmic drug evaluation. , 1999, Circulation.

[3]  R. Ideker,et al.  Estimation of conduction velocity vector fields from epicardial mapping data , 1998, IEEE Transactions on Biomedical Engineering.

[4]  B. R. Jewell,et al.  A study of the factors responsible for rate‐dependent shortening of the action potential in mammalian ventricular muscle. , 1978, The Journal of physiology.

[5]  R. Gray,et al.  An Experimentalist's Approach to Accurate Localization of Phase Singularities during Reentry , 2004, Annals of Biomedical Engineering.

[6]  A. Karma.  Electrical alternans and spiral wave breakup in cardiac tissue. , 1994, Chaos.

[7]  M. Allessie,et al.  Anisotropic conduction and reentry in perfused epicardium of rabbit left ventricle. , 1992, The American journal of physiology.

[8]  D. Rosenbaum,et al.  Modulated dispersion explains changes in arrhythmia vulnerability during premature stimulation of the heart. , 1998, Circulation.

[9]  M R Franz,et al.  The vulnerable period for low and high energy T-wave shocks: role of dispersion of repolarisation and effect of d-sotalol. , 1996, Cardiovascular research.

[10]  R. Gilmour,et al.  Electrical restitution and spatiotemporal organization during ventricular fibrillation. , 1999, Circulation research.

[11]  R. Gray,et al.  Shock-induced figure-of-eight reentry in the isolated rabbit heart. , 1999, Circulation research.

[12]  R. W. Joyner,et al.  Cellular mechanism of the functional refractory period in ventricular muscle. , 1990, Circulation research.

[13]  A. Garfinkel,et al.  Mechanisms of Discordant Alternans and Induction of Reentry in Simulated Cardiac Tissue , 2000, Circulation.

[14]  J Jalife,et al.  A mechanism of transition from ventricular fibrillation to tachycardia : effect of calcium channel blockade on the dynamics of rotating waves. , 2000, Circulation research.

[15]  J. C. Bailey,et al.  Action potential duration alternans in dog Purkinje and ventricular muscle fibers. Further evidence in support of two different mechanisms. , 1989, Circulation.

[16]  G. Diamond,et al.  Action Potential Alternans and Irregular Dynamics in Quinidine‐Intoxicated Ventricular Muscle Cells Implications for Ventricular Proarrhythmia , 1993, Circulation.

[17]  A Garfinkel,et al.  Effects of diacetyl monoxime and cytochalasin D on ventricular fibrillation in swine right ventricles. , 2001, American journal of physiology. Heart and circulatory physiology.

[18]  A Garfinkel,et al.  Spatiotemporal heterogeneity in the induction of ventricular fibrillation by rapid pacing: importance of cardiac restitution properties. , 1999, Circulation research.

[19]  R E Ideker,et al.  Fibrillation is More Complex in the Left Ventricle than in the Right Ventricle , 2000, Journal of cardiovascular electrophysiology.

[20]  J. Jalife,et al.  A Fungal Metabolite That Eliminates Motion Artifacts , 1998, Journal of cardiovascular electrophysiology.

[21]  F. Fenton,et al.  Vortex dynamics in three-dimensional continuous myocardium with fiber rotation: Filament instability and fibrillation. , 1998, Chaos.

[22]  B. Surawicz,et al.  Cycle length effect on restitution of action potential duration in dog cardiac fibers. , 1983, The American journal of physiology.

[23]  A Garfinkel,et al.  Cardiac electrical restitution properties and stability of reentrant spiral waves: a simulation study. , 1999, The American journal of physiology.

[24]  Alan Garfinkel,et al.  Spatiotemporal Chaos in a Simulated Ring of Cardiac Cells , 1997 .

[25]  Guy Salama,et al.  Simultaneous maps of optical action potentials and calcium transients in guinea‐pig hearts: mechanisms underlying concordant alternans , 2000, The Journal of physiology.

[26]  D. Zipes,et al.  Cytochalasin D as Excitation‐Contraction Uncoupler for Optically Mapping Action Potentials in Wedges of Ventricular Myocardium , 1998, Journal of cardiovascular electrophysiology.

[27]  D. Zipes,et al.  Differential Effects of Cytochalasin D and 2, 3 Butanedione Monoxime on Isometric Twitch Force and Transmembrane Action Potential in Isolated Ventricular Muscle: Implications for Optical Measurements of Cardiac Repolarization , 1998, Journal of cardiovascular electrophysiology.

[28]  M. Franz,et al.  Cycle length dependence of human action potential duration in vivo. Effects of single extrastimuli, sudden sustained rate acceleration and deceleration, and different steady-state frequencies. , 1988, The Journal of clinical investigation.

[29]  B M Salzberg,et al.  Multiple site optical recording of transmembrane voltage (MSORTV) in patterned growth heart cell cultures: assessing electrical behavior, with microsecond resolution, on a cellular and subcellular scale. , 1994, Biophysical journal.

[30]  C. Wiggers,et al.  Studies of Ventricular Fibrillation Caused by Electric Shock: , 1930, Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc.

[31]  J. Davidenko,et al.  Effects of diacetyl monoxime on the electrical properties of sheep and guinea pig ventricular muscle. , 1993, Cardiovascular research.

[32]  J. Nolasco,et al.  A graphic method for the study of alternation in cardiac action potentials. , 1968, Journal of applied physiology.

[33]  M. Koller,et al.  Dynamic restitution of action potential duration during electrical alternans and ventricular fibrillation. , 1998, American journal of physiology. Heart and circulatory physiology.

[34]  Harold M. Hastings,et al.  Memory in an Excitable Medium: A Mechanism for Spiral Wave Breakup in the Low-Excitability Limit , 1999 .

[35]  W. Rheinboldt,et al.  A COMPUTER MODEL OF ATRIAL FIBRILLATION. , 1964, American heart journal.

[36]  H M Hastings,et al.  Mechanisms for Discordant Alternans , 2001, Journal of cardiovascular electrophysiology.

[37]  L. Glass,et al.  Instabilities of a propagating pulse in a ring of excitable media. , 1993, Physical review letters.

[38]  I R Efimov,et al.  Reversal of Repolarization Gradient Does Not Reverse the Chirality of Shock‐Induced Reentry in the Rabbit Heart , 2000, Journal of cardiovascular electrophysiology.

[39]  D. Rosenbaum,et al.  Optical mapping in a new guinea pig model of ventricular tachycardia reveals mechanisms for multiple wavelengths in a single reentrant circuit. , 1996, Circulation.

[40]  J Jalife,et al.  Effects of atrial defibrillation shocks on the ventricles in isolated sheep hearts. , 1998, Circulation.

[41]  Daniel J Gauthier,et al.  Experimental control of cardiac muscle alternans. , 2002, Physical review letters.

[42]  M R Franz,et al.  Myocardial Vulnerability to T Wave Shocks: Relation to Shock Strength, Shock Coupling Interval, and Dispersion of Ventricular Repolarization , 1996, Journal of cardiovascular electrophysiology.

[43]  G. Salama,et al.  The Distribution of Refractory Periods Influences the Dynamics of Ventricular Fibrillation , 2001, Circulation research.

[44]  D. Rosenbaum,et al.  Modulation of ventricular repolarization by a premature stimulus. Role of epicardial dispersion of repolarization kinetics demonstrated by optical mapping of the intact guinea pig heart. , 1996, Circulation research.

[45]  H. Ahammer,et al.  Di-4-ANEPPS causes photodynamic damage to isolated cardiomyocytes , 1994, Pflügers Archiv.

[46]  R. Gilmour,et al.  Memory and complex dynamics in cardiac Purkinje fibers. , 1997, The American journal of physiology.

[47]  B. C. Hill,et al.  Effects of bipolar point and line stimulation in anisotropic rabbit epicardium: assessment of the critical radius of curvature for longitudinal block , 1995, IEEE Transactions on Biomedical Engineering.

[48]  R. Gray,et al.  Spatial and temporal organization during cardiac fibrillation , 1998, Nature.

[49]  M R Franz,et al.  Differential Effects of D‐Sotalol, Quinidine, and Amiodarone on Dispersion of Ventricular Repolarization in the Isolated Rabbit Heart , 1997, Journal of cardiovascular electrophysiology.

[50]  V. Fast,et al.  Cardiac tissue geometry as a determinant of unidirectional conduction block: assessment of microscopic excitation spread by optical mapping in patterned cell cultures and in a computer model. , 1995, Cardiovascular research.

[51]  M. Simson,et al.  Oscillations of conduction, action potential duration, and refractoriness. A mechanism for spontaneous termination of reentrant tachycardias. , 1988, Circulation.

[52]  R. Gilmour,et al.  Biphasic restitution of action potential duration and complex dynamics in ventricular myocardium. , 1995, Circulation research.

[53]  D. T. Kaplan,et al.  Repolarization Inhomogeneities in Ventricular Myocardium Change Dynamically With Abrupt Cycle Length Shortening , 1991, Circulation.