The long-acting glucagon-like peptide-1 analogue, liraglutide, inhibits beta-cell apoptosis in vitro.

[1]  M. Cnop,et al.  Free Fatty Acids and Cytokines Induce Pancreatic β-Cell Apoptosis by Different Mechanisms: Role of Nuclear Factor-κB and Endoplasmic Reticulum Stress , 2004 .

[2]  Jeppe Sturis,et al.  One week's treatment with the long-acting glucagon-like peptide 1 derivative liraglutide (NN2211) markedly improves 24-h glycemia and alpha- and beta-cell function and reduces endogenous glucose release in patients with type 2 diabetes. , 2004, Diabetes.

[3]  M. Mcdaniel,et al.  cAMP Dose-dependently Prevents Palmitate-induced Apoptosis by Both Protein Kinase A- and cAMP-Guanine Nucleotide Exchange Factor-dependent Pathways in β-Cells* , 2004, Journal of Biological Chemistry.

[4]  R. Perfetti,et al.  GLP-1 inhibition of pancreatic islet cell apoptosis , 2004, Trends in Endocrinology & Metabolism.

[5]  J. Lord,et al.  Regulation of neutrophil apoptosis: A role for protein kinase C and phosphatidylinositol-3-kinase , 2000, Apoptosis.

[6]  H. Noushmehr,et al.  Glucagon-like peptide 1 inhibits cell apoptosis and improves glucose responsiveness of freshly isolated human islets. , 2003, Endocrinology.

[7]  R. Perfetti,et al.  Glucagon-like peptide-1 inhibits apoptosis of insulin-secreting cells via a cyclic 5'-adenosine monophosphate-dependent protein kinase A- and a phosphatidylinositol 3-kinase-dependent pathway. , 2003, Endocrinology.

[8]  Yazhou Li,et al.  Glucagon-like Peptide-1 Receptor Signaling Modulates β Cell Apoptosis* , 2003, The Journal of Biological Chemistry.

[9]  R. Curi,et al.  Improvement of the mitochondrial antioxidant defense status prevents cytokine-induced nuclear factor-kappaB activation in insulin-producing cells. , 2003, Diabetes.

[10]  R. Perfetti,et al.  Glucagon-like peptide-1 promotes islet cell growth and inhibits apoptosis in Zucker diabetic rats. , 2002, Endocrinology.

[11]  Michele Purrello,et al.  Chronic exposure to free fatty acids or high glucose induces apoptosis in rat pancreatic islets: possible role of oxidative stress. , 2002, Metabolism: clinical and experimental.

[12]  U. Boggi,et al.  Prolonged exposure to free fatty acids has cytostatic and pro-apoptotic effects on human pancreatic islets: evidence that beta-cell death is caspase mediated, partially dependent on ceramide pathway, and Bcl-2 regulated. , 2002, Diabetes.

[13]  B. Portha,et al.  Glucagon-like peptide-1 and exendin-4 stimulate beta-cell neogenesis in streptozotocin-treated newborn rats resulting in persistently improved glucose homeostasis at adult age. , 2001, Diabetes.

[14]  H. Koh,et al.  Drosophila phosphoinositide-dependent kinase-1 regulates apoptosis and growth via the phosphoinositide 3-kinase-dependent signaling pathway , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[15]  C. Wright,et al.  Glucagon-like peptide 1 induces differentiation of islet duodenal homeobox-1-positive pancreatic ductal cells into insulin-secreting cells. , 2001, Diabetes.

[16]  M. White,et al.  IRS proteins and beta-cell function. , 2001, Diabetes.

[17]  T. Mandrup-Poulsen beta-cell apoptosis: stimuli and signaling. , 2001, Diabetes.

[18]  B. Friedrichsen,et al.  Regulation of beta-cell mass by hormones and growth factors. , 2001, Diabetes.

[19]  D. Drucker,et al.  Minireview: the glucagon-like peptides. , 2001, Endocrinology.

[20]  J. Richards,et al.  New Signaling Pathways for Hormones and Cyclic Adenosine 3؅,5؅-monophosphate Action in Endocrine Cells , 2022 .

[21]  L. Orci,et al.  Diseases of liporegulation: new perspective on obesity and related disorders , 2001, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[22]  P. J. Larsen,et al.  GLP-1 derivatives as novel compounds for the treatment of type 2 diabetes: Selection of NN2211 for clinical development , 2001 .

[23]  K. Maedler,et al.  Distinct effects of saturated and monounsaturated fatty acids on beta-cell turnover and function. , 2001, Diabetes.

[24]  X. Shen,et al.  Rapid activation of protein kinase B/Akt has a key role in antiapoptotic signaling during liver regeneration. , 2000, Biochemical and biophysical research communications.

[25]  D. Hörsch,et al.  Integrative Mitogenic Role of Protein Kinase B/Akt in β‐Cells , 2000 .

[26]  R. Perfetti,et al.  Glucagon-like peptide-1: a major regulator of pancreatic beta-cell function. , 2000, European journal of endocrinology.

[27]  Jie Zhou,et al.  Glucagon-Like Peptide-1 Induces Cell Proliferation and Pancreatic-Duodenum Homeobox-1 Expression and Increases Endocrine Cell Mass in the Pancreas of Old, Glucose-Intolerant Rats. , 2000, Endocrinology.

[28]  B. Yusta,et al.  The Glucagon-like Peptide-2 Receptor Mediates Direct Inhibition of Cellular Apoptosis via a cAMP-dependent Protein Kinase-independent Pathway* , 2000, The Journal of Biological Chemistry.

[29]  E. Ryan,et al.  Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimen. , 2000, The New England journal of medicine.

[30]  L. B. Knudsen,et al.  Potent derivatives of glucagon-like peptide-1 with pharmacokinetic properties suitable for once daily administration. , 2000, Journal of medicinal chemistry.

[31]  J. Lord,et al.  Serine/threonine protein kinases and apoptosis. , 2000, Experimental cell research.

[32]  J. Miyazaki,et al.  Tumor necrosis factor alpha signaling pathway and apoptosis in pancreatic β cells , 1999 .

[33]  J. Habener,et al.  The glucagon-like peptides. , 1999, Endocrine reviews.

[34]  S. Bonner-Weir,et al.  Exendin-4 stimulates both beta-cell replication and neogenesis, resulting in increased beta-cell mass and improved glucose tolerance in diabetic rats. , 1999, Diabetes.

[35]  M. Prentki,et al.  Glucagon-like peptide-1 promotes DNA synthesis, activates phosphatidylinositol 3-kinase and increases transcription factor pancreatic and duodenal homeobox gene 1 (PDX-1) DNA binding activity in beta (INS-1)-cells , 1999, Diabetologia.

[36]  J. Petrik,et al.  Insulin-like growth factors prevent cytokine-mediated cell death in isolated islets of Langerhans from pre-diabetic non-obese diabetic mice. , 1999, The Journal of endocrinology.

[37]  M. Bernier,et al.  Pancreatic Glucagon-Like Peptide-1 Receptor Couples to Multiple G Proteins and Activates Mitogen-Activated Protein Kinase Pathways in Chinese Hamster Ovary Cells * , 1999 .

[38]  D. Mauricio,et al.  Apoptosis and the pathogenesis of IDDM: a question of life and death. , 1998, Diabetes.

[39]  C. Newgard,et al.  Protection against lipoapoptosis of beta cells through leptin-dependent maintenance of Bcl-2 expression. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[40]  R. Unger,et al.  Fatty acid-induced β cell apoptosis: A link between obesity and diabetes , 1998 .

[41]  M. Claesson,et al.  MHC class I ligation of human T cells activates the ZAP70 and p56lck tyrosine kinases, leads to an alternative phenotype of the TCR/CD3 zeta-chain, and induces apoptosis. , 1997, Journal of immunology.

[42]  M. Claesson,et al.  Ligation of MHC class I molecules on peripheral blood T lymphocytes induces new phenotypes and functions. , 1996, Journal of immunology.

[43]  G. Sharp,et al.  Glucose-dependent insulinotropic polypeptide stimulates insulin secretion via increased cyclic AMP and [Ca2+]1 and a wortmannin-sensitive signalling pathway. , 1996, Biochemical and biophysical research communications.