(S)-(+)-methadone is more immunosuppressive than the potent analgesic (R)-(--)-methadone.

[1]  A. Somogyi,et al.  Relationship between 4,5-epoxymorphinan structure and in vitro modulation of cell proliferation. , 2004, European journal of pharmacology.

[2]  A. Somogyi,et al.  Diacetylmorphine degradation to 6-monoacetylmorphine and morphine in cell culture: implications for in vitro studies. , 2002, European journal of pharmacology.

[3]  D. Lysle,et al.  Morphine-6β-glucuronide induces potent immunomodulation , 2001 .

[4]  D. Bridge,et al.  The rediscovery of methadone for cancer pain management , 2000, The Medical journal of Australia.

[5]  H. Loveren,et al.  Effects of prolonged exposure to morphine and methadone on in vivo parameters of immune function in rats. , 1998 .

[6]  D. Lysle,et al.  Evidence for sympathetic and adrenal involvement in the immunomodulatory effects of acute morphine treatment in rats. , 1996, The Journal of pharmacology and experimental therapeutics.

[7]  J. Carmody Avoiding fallacies in nociceptive measurements , 1995, Pain.

[8]  R. Shank,et al.  Serotonin and norepinephrine uptake inhibiting activity of centrally acting analgesics: structural determinants and role in antinociception. , 1995, The Journal of pharmacology and experimental therapeutics.

[9]  P. Krogsgaard‐Larsen,et al.  Ketobemidone, methadone and pethidine are non-competitive N-methyl-d-aspartate (NMDA) antagonists in the rat cortex and spinal cord , 1995, Neuroscience Letters.

[10]  J. A. Mccay,et al.  The Effect of Methadone on the Immune Status of B6C3F1 Mice , 1995 .

[11]  R. House,et al.  Direct cellular immunomodulation produced by diacetylmorphine (heroin) or methadone. , 1995, General pharmacology.

[12]  L. Christrup,et al.  The mu1, mu2, delta, kappa opioid receptor binding profiles of methadone stereoisomers and morphine. , 1995, Life sciences.

[13]  D. D. Des Jarlais,et al.  Fortnightly Review: Methadone maintenance treatment in opiate dependence: a review , 1994 .

[14]  D. Parolaro,et al.  Effect of morphine and methadone acute treatment on immunological activity in mice: pharmacokinetic and pharmacodynamic correlates. , 1994, The Journal of pharmacology and experimental therapeutics.

[15]  M. Kreek,et al.  In vitro studies of the effect of methadone on natural killer cell activity. , 1990, Israel journal of medical sciences.

[16]  N. Sibinga,et al.  Opioid peptides and opioid receptors in cells of the immune system. , 1988, Annual review of immunology.

[17]  A. Jakubovic,et al.  Suppressive effects of methadone on human blood lymphocytes , 1980 .