A Principle of Neuromechanical Matching for Motor Unit Recruitment in Human Movement.

What determines which motor units are active in a motor task? In the respiratory muscles, motor units are recruited according to their mechanical advantages. We describe a principle of motor unit recruitment by neuromechanical matching due to mechanisms in the spinal cord that sculpt descending drive to motoneurons. This principle may be applicable to movements in nonrespiratory muscles.

[1]  E. Henneman Relation between size of neurons and their susceptibility to discharge. , 1957, Science.

[2]  E Henneman,et al.  Responses of motoneurons of different sizes to graded stimulation of supraspinal centers of the brain. , 1965, Journal of neurophysiology.

[3]  E Jankowska,et al.  A comparison of peripheral and rubrospinal synaptic input to slow and fast twitch motor units of triceps surae , 1970, The Journal of physiology.

[4]  R B Stein,et al.  The orderly recruitment of human motor units during voluntary isometric contractions , 1973, The Journal of physiology.

[5]  J. Stephens,et al.  The reflex responses of single motor units in human first dorsal interosseous muscle following cutaneous afferent stimulation. , 1980, The Journal of physiology.

[6]  H. E. Desnedt,et al.  Spinal motoneuron recruitment in man: rank deordering with direction but not with speed of voluntary movement. , 1981, Science.

[7]  N. Larnicol,et al.  Spinal localization of the intercostal motoneurones innervating the upper thoracic spaces , 1982, Neuroscience Letters.

[8]  C. C. A. M. Gielen,et al.  Changes in recruitment order of motor units in the human biceps muscle , 1982, Experimental Neurology.

[9]  J E Desmedt,et al.  Cutaneous facilitation of large motor units and motor control of human fingers in precision grip. , 1983, Advances in neurology.

[10]  D Burke,et al.  Absence of somatotopic projection of muscle afferents onto motoneurons of same muscle. , 1984, Journal of neurophysiology.

[11]  T. Sears,et al.  The distribution of monosynaptic connexions from inspiratory bulbospinal neurones to inspiratory motoneurones in the cat. , 1985, The Journal of physiology.

[12]  G. Loeb Motoneurone task groups: coping with kinematic heterogeneity. , 1985, The Journal of experimental biology.

[13]  R. Stein,et al.  Motor-unit recruitment in human first dorsal interosseous muscle for static contractions in three different directions. , 1986, Journal of neurophysiology.

[14]  B. Calancie,et al.  Human motor-unit recruitment during isometric contractions and repeated dynamic movements. , 1987, Journal of neurophysiology.

[15]  W. Whitelaw,et al.  Voluntary hyperventilation changes recruitment order of parasternal intercostal motor units. , 1987, Journal of applied physiology.

[16]  C. Gielen,et al.  Coordination and inhomogeneous activation of human arm muscles during isometric torques. , 1988, Journal of neurophysiology.

[17]  Daniel Kernell,et al.  Synaptic effects on recruitment gain: a mechanism of importance for the input-output relations of motoneurone pools? , 1990, Brain Research.

[18]  J. Greer,et al.  Distribution of muscle fiber types and EMG activity in cat intercostal muscles. , 1990, Journal of applied physiology.

[19]  S. Riek,et al.  Recruitment of motor units in human forearm extensors. , 1992, Journal of neurophysiology.

[20]  C. Heckman,et al.  The Physiological Control of Motoneuron Activity , 1996 .

[21]  L. Rowell,et al.  Exercise : regulation and integration of multiple systems , 1996 .

[22]  T. Fukunaga,et al.  Architectural and functional features of human triceps surae muscles during contraction. , 1998, Journal of applied physiology.

[23]  B. Bishop,et al.  Abdominal motor unit activity during respiratory and nonrespiratory tasks. , 1998, Journal of applied physiology.

[24]  T. Cope,et al.  Recruitment order among motoneurons from different motor nuclei. , 1999, Journal of neurophysiology.

[25]  S. Gandevia,et al.  Discharge properties and recruitment of human diaphragmatic motor units during voluntary inspiratory tasks , 1999, The Journal of physiology.

[26]  Timothy C. Cope,et al.  Orderly recruitment among motoneurons supplying different muscles , 1999, Journal of Physiology-Paris.

[27]  A. G. Cresswell,et al.  The effect of muscle length on motor-unit recruitment during isometric plantar flexion in humans , 2000, Experimental Brain Research.

[28]  A. Bitton,et al.  Regional differences in serotonergic input to canine parasternal intercostal motoneurons. , 2000, Journal of applied physiology.

[29]  R. Gorman,et al.  Distribution of inspiratory drive to the external intercostal muscles in humans , 2003, The Journal of physiology.

[30]  C. Pratt,et al.  Functionally complex muscles of the cat hindlimb , 2004, Experimental Brain Research.

[31]  P. Kirkwood,et al.  Respiratory action of the intercostal muscles. , 2005, Physiological reviews.

[32]  Simon C Gandevia,et al.  Spatial distribution of inspiratory drive to the parasternal intercostal muscles in humans , 2006, The Journal of physiology.

[33]  S. Gandevia,et al.  The effect of lung volume on the co‐ordinated recruitment of scalene and sternomastoid muscles in humans , 2007, The Journal of physiology.

[34]  C. Peck,et al.  Regional properties of the superior head of human lateral pterygoid muscle. , 2008, European journal of oral sciences.

[35]  James M Wakeling,et al.  Motor unit recruitment patterns 1: responses to changes in locomotor velocity and incline , 2008, Journal of Experimental Biology.

[36]  S. Gandevia,et al.  The output from human inspiratory motoneurone pools , 2008, The Journal of physiology.

[37]  D Farina,et al.  Motor units in cranial and caudal regions of the upper trapezius muscle have different discharge rates during brief static contractions , 2008, Acta physiologica.

[38]  Simon C Gandevia,et al.  Coupling between mechanical and neural behaviour in the human first dorsal interosseous muscle , 2009, The Journal of physiology.

[39]  Interplay between the inspiratory and postural functions of the human parasternal intercostal muscles. , 2010, Journal of neurophysiology.

[40]  S. Gandevia,et al.  Control of human inspiratory motoneurones during voluntary and involuntary contractions , 2011, Respiratory Physiology & Neurobiology.

[41]  A. Boriek,et al.  Mechanics of the respiratory muscles. , 2011, Comprehensive Physiology.

[42]  Spinal breathing: stimulation and surprises , 2011, The Journal of physiology.

[43]  L. Mendell,et al.  Functional Organization of Motoneuron Pool and its Inputs , 2011 .

[44]  S. Gandevia,et al.  Common rostrocaudal gradient of output from human intercostal motoneurones during voluntary and automatic breathing , 2011, Respiratory Physiology & Neurobiology.

[45]  Michael A. Lane,et al.  Spinal respiratory motoneurons and interneurons , 2011, Respiratory Physiology & Neurobiology.

[46]  H. Hultborn,et al.  Voltage‐dependent amplification of synaptic inputs in respiratory motoneurones , 2012, The Journal of physiology.

[47]  A. Dimarco,et al.  Activation of inspiratory muscles via spinal cord stimulation , 2013, Respiratory Physiology & Neurobiology.

[48]  John Timothy Inglis,et al.  Absence of lateral gastrocnemius activity and differential motor unit behavior in soleus and medial gastrocnemius during standing balance. , 2014, Journal of applied physiology.

[49]  P. Hodges,et al.  Anticipatory postural activity of the deep trunk muscles differs between anatomical regions based on their mechanical advantage , 2014, Neuroscience.

[50]  S. Gandevia,et al.  The neural control of human inspiratory muscles. , 2014, Progress in brain research.

[51]  Gunter P Siegmund,et al.  Motor units in the human medial gastrocnemius muscle are not spatially localized or functionally grouped , 2015, The Journal of physiology.

[52]  Annie A Butler,et al.  Activation of human inspiratory muscles in an upside-down posture , 2016, Respiratory Physiology & Neurobiology.

[53]  W Herzog,et al.  Residual Force Enhancement Following Eccentric Contractions: A New Mechanism Involving Titin. , 2016, Physiology.

[54]  J. Blouin,et al.  Regionalization of the stretch reflex in the human vastus medialis , 2017, The Journal of physiology.

[55]  S. Gandevia,et al.  Task‐dependent output of human parasternal intercostal motor units across spinal levels , 2017, The Journal of physiology.

[56]  Randall K Powers,et al.  The potential for understanding the synaptic organization of human motor commands via the firing patterns of motoneurons. , 2017, Journal of neurophysiology.