Bubble growth in cylindrically-shaped optical absorbers during photo-mediated ultrasound therapy.

Photo-mediated ultrasound therapy (PUT) is a non-invasive, agent-free technique to shut down microvessels with high precision by promoting cavitation activity precisely in the targeted microvessels. PUT is based on the photoacoustic (PA) cavitation generated through concurrently applied nanosecond laser pulses and ultrasound bursts. In this study, a PA cavitation model is employed to understand the enhanced cavitation activity during PUT, with full consideration of the optical absorption of blood vessels. Bubble size evolution in cylindrically-shaped optical absorbers (vessels) due to rectified diffusion is simulated. Results show that the ultrasound pressure required for bubble growth decreases dramatically with the increased laser fluence. At a relatively low ultrasound driving pressure, bubble equilibrium radius increases rapidly due to concurrently applied nanosecond laser pulses and ultrasound bursts, resulting in a transition from inertial cavitation to stable cavitation. This inertial to stable transition is verified by the experimentally measured results on 0.76 mm silicone tubes filled with human whole blood with 0.5 MHz ultrasound at 0.243 MPa. This study demonstrated the potential to induce stable bubbles in blood vessels by PUT non-invasively.

[1]  H. Hoffman,et al.  Photospallation: a new theory and mechanism for mid-infrared corneal ablations. , 2000, Journal of refractive surgery.

[2]  Hongqin Wei,et al.  Hemostatic Effects of Microbubble-Enhanced Low-Intensity Ultrasound in a Liver Avulsion Injury Model , 2014, PloS one.

[3]  G. Paltauf,et al.  Photoacoustic cavitation in spherical and cylindrical absorbers , 1999 .

[4]  Ronald A. Roy,et al.  Nucleating cavitation from laser-illuminated nano-particles , 2005 .

[5]  R. White,et al.  Pulmonary arteriovenous malformations: diagnosis and transcatheter embolotherapy. , 1996, Journal of vascular and interventional radiology : JVIR.

[6]  Ronald A. Roy,et al.  Ultrasonic enhancement of photoacoustic emissions by nanoparticle-targeted cavitation. , 2010, Optics letters.

[7]  D M Eckmann,et al.  Bubble motion in a blood vessel: shear stress induced endothelial cell injury. , 2009, Journal of biomechanical engineering.

[8]  C. Church,et al.  Prediction of rectified diffusion during nonlinear bubble pulsations at biomedical frequencies. , 1988, The Journal of the Acoustical Society of America.

[9]  Ralph M Bunte,et al.  The antivascular action of physiotherapy ultrasound on a murine tumor: role of a microbubble contrast agent. , 2007, Ultrasound in medicine & biology.

[10]  C. Cain,et al.  Noninvasive thrombolysis using pulsed ultrasound cavitation therapy - histotripsy. , 2009, Ultrasound in medicine & biology.

[11]  Zhen Xu,et al.  Noninvasive treatment of deep venous thrombosis using pulsed ultrasound cavitation therapy (histotripsy) in a porcine model. , 2011, Journal of vascular and interventional radiology : JVIR.

[12]  Xueding Wang,et al.  Antivascular photo-mediated ultrasound therapy , 2016, 2016 IEEE International Ultrasonics Symposium (IUS).

[13]  B. Ballermann,et al.  Shear stress and the endothelium. , 1998, Kidney international. Supplement.

[14]  K. Nightingale,et al.  A theoretical study of inertial cavitation from acoustic radiation force impulse imaging and implications for the mechanical index. , 2015, Ultrasound in medicine & biology.

[15]  Lawrence A Crum,et al.  Vascular effects induced by combined 1-MHz ultrasound and microbubble contrast agent treatments in vivo. , 2005, Ultrasound in medicine & biology.

[16]  M. Tanter,et al.  Statistics of acoustically induced bubble-nucleation events in in vitro blood: a feasibility study. , 2013, Ultrasound in medicine & biology.

[17]  Michael D Feldman,et al.  The antivascular action of physiotherapy ultrasound on murine tumors. , 2005, Ultrasound in medicine & biology.

[18]  Günther Paltauf,et al.  Photomechanical processes and effects in ablation. , 2003, Chemical reviews.

[19]  Katherine W Ferrara,et al.  Insonation of Targeted Microbubbles Produces Regions of Reduced Blood Flow Within Tumor Vasculature , 2012, Investigative radiology.

[20]  J. Geschwind,et al.  Intra-Arterial Therapies for Hepatocellular Carcinoma: Where Do We Stand? , 2010, Annals of Surgical Oncology.

[21]  Bastien Arnal,et al.  Sono-photoacoustic imaging of gold nanoemulsions: Part II. Real time imaging , 2015, Photoacoustics.

[22]  Zhen Xu,et al.  Probability of cavitation for single ultrasound pulses applied to tissues and tissue-mimicking materials. , 2013, Ultrasound in medicine & biology.

[23]  C. Church,et al.  Spontaneous homogeneous nucleation, inertial cavitation and the safety of diagnostic ultrasound. , 2002, Ultrasound in medicine & biology.

[24]  H. Hoffman,et al.  Minimizing Thermal Damage in Corneal Ablation with Short Pulse Mid-infrared Lasers. , 1999, Journal of biomedical optics.

[25]  Xinmai Yang,et al.  High-precision, non-invasive anti-microvascular approach via concurrent ultrasound and laser irradiation , 2017, Scientific Reports.

[26]  S. Mitchell,et al.  Pulmonary arteriovenous malformations: techniques and long-term outcome of embolotherapy. , 1988, Radiology.

[27]  C. Church,et al.  A theoretical study of cavitation generated by an extracorporeal shock wave lithotripter. , 1988, The Journal of the Acoustical Society of America.

[28]  Xinmai Yang,et al.  Laser-enhanced high-intensity focused ultrasound heating in an in vivo small animal model. , 2016, Applied physics letters.

[29]  Ronald A. Roy,et al.  Gold nanoparticle targeted photoacoustic cavitation for potential deep tissue imaging and therapy , 2012, Biomedical optics express.

[30]  K. Hynynen.  The threshold for thermally significant cavitation in dog's thigh muscle in vivo. , 1991, Ultrasound in medicine & biology.

[31]  Michael J. Miksis,et al.  Bubble Oscillations of Large Amplitude , 1980 .

[32]  B. Li,et al.  Bubble dynamics and shock waves generated by laser absorption of a photoacoustic sphere , 2000 .

[33]  H. H. Pennes.  Analysis of tissue and arterial blood temperatures in the resting human forearm. 1948. , 1948, Journal of applied physiology.

[34]  Nico de Jong,et al.  Droplets, Bubbles and Ultrasound Interactions. , 2016, Advances in experimental medicine and biology.

[35]  Lihong V. Wang,et al.  Biomedical Optics: Principles and Imaging , 2007 .

[36]  M. O’Donnell,et al.  Sono-photoacoustic imaging of gold nanoemulsions: Part I. Exposure thresholds , 2015, Photoacoustics.

[37]  A. Vogel,et al.  Mechanisms of pulsed laser ablation of biological tissues. , 2003, Chemical reviews.

[38]  J. Haga,et al.  Molecular basis of the effects of shear stress on vascular endothelial cells. , 2005, Journal of biomechanics.

[39]  Saurabh Datta,et al.  Correlation of cavitation with ultrasound enhancement of thrombolysis. , 2006, Ultrasound in medicine & biology.