Biomarkers for Alzheimer's disease: academic, industry and regulatory perspectives
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Wendy R. Sanhai | K. Blennow | F. Jessen | J. Hardy | K. Herholz | H. Hampel | Arun L. W. Bokde | S. Teipel | J. Woodcock | H. Zetterberg | K. Broich | R. Frank | W. Sanhai | R. Katz | Yvonne C. Hoessler | J. Hardy
[1] Robert Cook-Deegan,et al. Disclosure of APOE genotype for risk of Alzheimer's disease. , 2009, The New England journal of medicine.
[2] Anders M. Dale,et al. Structural Neuroimaging in the Detection and Prognosis of Pre-Clinical and Early AD , 2009, Behavioural neurology.
[3] L. Kiemeney,et al. Corrigendum: Genetic variation in the prostate stem cell antigen gene PSCA confers susceptibility to urinary bladder cancer , 2009, Nature Genetics.
[4] P. Bosco,et al. Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease , 2009, Nature Genetics.
[5] W. M. van der Flier,et al. CSF biomarkers and incipient Alzheimer disease in patients with mild cognitive impairment. , 2009, JAMA.
[6] Magda Tsolaki,et al. Prevalence and prognostic value of CSF markers of Alzheimer's disease pathology in patients with subjective cognitive impairment or mild cognitive impairment in the DESCRIPA study: a prospective cohort study , 2009, The Lancet Neurology.
[7] P. Aisen,et al. Lessons learned in the use of volumetric MRI in therapeutic trials in Alzheimer’s disease: The Alzhemedtm (Tramiprosate) experience , 2009, The journal of nutrition, health & aging.
[8] E. Siemers. How can we recognize “disease modification” effects? , 2009, The journal of nutrition, health & aging.
[9] B. Hyman,et al. Existing plaques and neuritic abnormalities in APP:PS1 mice are not affected by administration of the gamma-secretase inhibitor LY-411575 , 2009, Molecular Neurodegeneration.
[10] R. Petersen,et al. Cerebrospinal fluid biomarker signature in Alzheimer's disease neuroimaging initiative subjects , 2009, Annals of neurology.
[11] Stefan J. Teipel,et al. Decreased Activation Along the Dorsal Visual Pathway After a 3-Month Treatment With Galantamine in Mild Alzheimer Disease: A Functional Magnetic Resonance Imaging Study , 2009, Journal of clinical psychopharmacology.
[12] Nick C Fox,et al. Long-Term Follow-Up of Patients Immunized with AN1792: Reduced Functional Decline in Antibody Responders , 2009, Current Alzheimer research.
[13] M. Carrillo,et al. Early risk assessment for Alzheimer's disease , 2009, Alzheimer's & Dementia.
[14] A. Fagan,et al. Alzheimer’s disease risk variants show association with cerebrospinal fluid amyloid beta , 2009, neurogenetics.
[15] Alison R. Gregro,et al. First Demonstration of Cerebrospinal Fluid and Plasma Aβ Lowering with Oral Administration of a β-Site Amyloid Precursor Protein-Cleaving Enzyme 1 Inhibitor in Nonhuman Primates , 2009, Journal of Pharmacology and Experimental Therapeutics.
[16] H. Engler,et al. PET imaging of amyloid deposition in patients with mild cognitive impairment , 2008, Neurobiology of Aging.
[17] K. Blennow,et al. Safety, efficacy, and biomarker findings of PBT2 in targeting Aβ as a modifying therapy for Alzheimer's disease: a phase IIa, double-blind, randomised, placebo-controlled trial , 2008, The Lancet Neurology.
[18] A. Fleisher,et al. Phase 2 safety trial targeting amyloid beta production with a gamma-secretase inhibitor in Alzheimer disease. , 2008, Archives of neurology.
[19] C. Masters,et al. Rapid Restoration of Cognition in Alzheimer's Transgenic Mice with 8-Hydroxy Quinoline Analogs Is Associated with Decreased Interstitial Aβ , 2008, Neuron.
[20] D. Goldstein,et al. Global pharmacogenetics: genetic substructure of Eurasian populations and its effect on variants of drug-metabolizing enzymes. , 2008, Pharmacogenomics.
[21] R. Black,et al. O3-04-05: Clinical trials of bapineuzumab, a beta-amyloid-targeted immunotherapy in patients with mild to moderate Alzheimer's disease , 2008, Alzheimer's & Dementia.
[22] K. Blennow,et al. O3-02-06: Elevated cerebrospinal fluid BACE1 activity in incipient Alzheimer's disease , 2008, Alzheimer's & Dementia.
[23] A. Fagan,et al. Variation in MAPT is associated with cerebrospinal fluid tau levels in the presence of amyloid-beta deposition , 2008, Proceedings of the National Academy of Sciences.
[24] Mark I. McCarthy,et al. A Genome-Wide Association Study Identifies Protein Quantitative Trait Loci (pQTLs) , 2008, PLoS genetics.
[25] C. Rowe,et al. Aβ deposits in older non-demented individuals with cognitive decline are indicative of preclinical Alzheimer's disease , 2008, Neuropsychologia.
[26] K. Blennow,et al. Effect of phenserine treatment on brain functional activity and amyloid in Alzheimer's disease , 2008, Annals of neurology.
[27] Nick C Fox,et al. The Alzheimer's disease neuroimaging initiative (ADNI): MRI methods , 2008, Journal of magnetic resonance imaging : JMRI.
[28] C. Jack,et al. 11C PiB and structural MRI provide complementary information in imaging of Alzheimer's disease and amnestic mild cognitive impairment. , 2008, Brain : a journal of neurology.
[29] C. Rowe,et al. Imaging of amyloid β in Alzheimer's disease with 18F-BAY94-9172, a novel PET tracer: proof of mechanism , 2008, The Lancet Neurology.
[30] Stefan J. Teipel,et al. Novel MRI techniques in the assessment of dementia , 2008, European Journal of Nuclear Medicine and Molecular Imaging.
[31] Janet Woodcock,et al. The FDA critical path initiative and its influence on new drug development. , 2008, Annual review of medicine.
[32] Herman Buschke,et al. Please Scroll down for Article International Review of Psychiatry Mild Cognitive Impairment: Believe It or Not? Mild Cognitive Impairment: Believe It or Not? , 2022 .
[33] K. Kantarci. 1H magnetic resonance spectroscopy in dementia. , 2007, The British journal of radiology.
[34] D. Stephan,et al. A survey of genetic human cortical gene expression , 2007, Nature Genetics.
[35] R. Tibshirani,et al. Classification and prediction of clinical Alzheimer's diagnosis based on plasma signaling proteins , 2007, Nature Medicine.
[36] Tetsuya Suhara,et al. Longitudinal, Quantitative Assessment of Amyloid, Neuroinflammation, and Anti-Amyloid Treatment in a Living Mouse Model of Alzheimer's Disease Enabled by Positron Emission Tomography , 2007, The Journal of Neuroscience.
[37] V. Libri,et al. PIB is a non-specific imaging marker of amyloid-beta (Abeta) peptide-related cerebral amyloidosis. , 2007, Brain : a journal of neurology.
[38] L. Lannfelt,et al. Reduction of Phosphorylated Tau during Memantine Treatment of Alzheimer’s Disease , 2007, Dementia and Geriatric Cognitive Disorders.
[39] P. Scheltens,et al. Research criteria for the diagnosis of Alzheimer's disease: revising the NINCDS–ADRDA criteria , 2007, The Lancet Neurology.
[40] Kathryn Ziegler-Graham,et al. Forecasting the global burden of Alzheimer’s disease , 2007, Alzheimer's & Dementia.
[41] Josephine Barnes,et al. Application of automated medial temporal lobe atrophy scale to Alzheimer disease. , 2007, Archives of neurology.
[42] Mauro Ferrari,et al. A critical path approach to advance nanoengineered medical products. , 2007, Drug discovery today. Technologies.
[43] Richard J. Caselli,et al. Correlations Between Apolipoprotein E ε4 Gene Dose and Whole Brain Atrophy Rates , 2007 .
[44] K. Blennow,et al. Longitudinal stability of CSF biomarkers in Alzheimer's disease , 2007, Neuroscience Letters.
[45] Hilkka Soininen,et al. CSF Aβ42, Tau and phosphorylated Tau, APOE ɛ4 allele and MCI type in progressive MCI , 2007, Neurobiology of Aging.
[46] Henrik Zetterberg,et al. Prediction of Alzheimer’s Disease Using the CSF Aβ42/Aβ40 Ratio in Patients with Mild Cognitive Impairment , 2007, Dementia and Geriatric Cognitive Disorders.
[47] J. Moffett,et al. N-Acetylaspartate in the CNS: From neurodiagnostics to neurobiology , 2007, Progress in Neurobiology.
[48] J. Lirng,et al. Prediction of Alzheimer's disease in mild cognitive impairment: A prospective study in Taiwan , 2006, Neurobiology of Aging.
[49] H. Engler,et al. Two-year follow-up of amyloid deposition in patients with Alzheimer's disease. , 2006, Brain : a journal of neurology.
[50] H. Soininen,et al. CSF phosphorylated tau protein correlates with neocortical neurofibrillary pathology in Alzheimer's disease. , 2006, Brain : a journal of neurology.
[51] John A. Wagner,et al. A cost-effectiveness approach to the qualification and acceptance of biomarkers , 2006, Nature Reviews Drug Discovery.
[52] Johannes Kornhuber,et al. Therapeutic approaches to Alzheimer's disease. , 2006, Brain : a journal of neurology.
[53] K. Blennow,et al. Neurochemical aftermath of amateur boxing , 2006, Archives of neurology.
[54] F. Jessen,et al. Treatment monitoring and response prediction with proton MR spectroscopy in AD , 2006, Neurology.
[55] F. Jessen,et al. Multicenter assessment of reliability of cranial MRI , 2006, Neurobiology of Aging.
[56] Henrik Zetterberg,et al. Plasma Aβ in Alzheimer's disease—up or down? , 2006, The Lancet Neurology.
[57] Steven Gutman,et al. Opinion: The US Food and Drug Administration perspective on cancer biomarker development , 2006, Nature Reviews Cancer.
[58] Stefan J. Teipel,et al. Effects of donepezil on cortical metabolic response to activation during 18FDG-PET in Alzheimer’s disease: a double-blind cross-over trial , 2006, Psychopharmacology.
[59] F. Bouwman,et al. Detection of a soluble form of BACE-1 in human cerebrospinal fluid by a sensitive activity assay. , 2006, Clinical chemistry.
[60] B. Reisberg,et al. Longitudinal CSF and MRI biomarkers improve the diagnosis of mild cognitive impairment , 2006, Neurobiology of Aging.
[61] Gina N. LaRossa,et al. Inverse relation between in vivo amyloid imaging load and cerebrospinal fluid Aβ42 in humans , 2006, Annals of neurology.
[62] R. Holsinger,et al. Left insular stroke is associated with adverse cardiac outcome , 2006, Neurology.
[63] A. Wall,et al. Longitudinal PET evaluation of cerebral glucose metabolism in rivastigmine treated patients with mild Alzheimer’s disease , 2006, Journal of Neural Transmission.
[64] T. Golde,et al. Anti-Aβ42– and anti-Aβ40–specific mAbs attenuate amyloid deposition in an Alzheimer disease mouse model , 2005 .
[65] J. Morris,et al. Antecedent Biomarkers of Alzheimer’s Disease: The Adult Children Study , 2005, Journal of geriatric psychiatry and neurology.
[66] M. Erb,et al. Cortical activation during cholinesterase-inhibitor treatment in Alzheimer disease: preliminary findings from a pharmaco-fMRI study. , 2005, The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry.
[67] J. Kaye,et al. Safety and Acceptability of the Research Lumbar Puncture , 2005, Alzheimer disease and associated disorders.
[68] C. Jack,et al. Ways toward an early diagnosis in Alzheimer’s disease: The Alzheimer’s Disease Neuroimaging Initiative (ADNI) , 2005, Alzheimer's & Dementia.
[69] Nick C Fox,et al. Clinical effects of Aβ immunization (AN1792) in patients with AD in an interrupted trial , 2005, Neurology.
[70] Ivo D Dinov,et al. Metabolic patterns associated with the clinical response to galantamine therapy: a fludeoxyglucose f 18 positron emission tomographic study. , 2005, Archives of neurology.
[71] Nick C Fox,et al. Effects of Aβ immunization (AN1792) on MRI measures of cerebral volume in Alzheimer disease , 2005, Neurology.
[72] N. Bohnen,et al. Degree of inhibition of cortical acetylcholinesterase activity and cognitive effects by donepezil treatment in Alzheimer’s disease , 2005, Journal of Neurology, Neurosurgery & Psychiatry.
[73] C. Mirkin,et al. Nanoparticle-based detection in cerebral spinal fluid of a soluble pathogenic biomarker for Alzheimer's disease. , 2005, Proceedings of the National Academy of Sciences of the United States of America.
[74] S. Wagner,et al. Reductions in β-amyloid concentrations in vivo by the γ-secretase inhibitors BMS-289948 and BMS-299897 , 2005 .
[75] Anders Wallin,et al. Simultaneous measurement of beta-amyloid(1-42), total tau, and phosphorylated tau (Thr181) in cerebrospinal fluid by the xMAP technology. , 2005, Clinical chemistry.
[76] B. L. Miller,et al. Reduced medial temporal lobe N-acetylaspartate in cognitively impaired but nondemented patients , 2005, Neurology.
[77] K. Ishii,et al. One-year change in cerebral glucose metabolism in patients with Alzheimer's disease. , 2004, The Journal of neuropsychiatry and clinical neurosciences.
[78] N. Logothetis,et al. Neural basis of the blood-oxygen-level-dependent functional magnetic resonance imaging , 2004 .
[79] C. Masters,et al. Increased β‐Secretase activity in cerebrospinal fluid of Alzheimer's disease subjects , 2004, Annals of neurology.
[80] M. Irizarry. Biomarkers of Alzheimer disease in plasma , 2004, NeuroRX.
[81] R. Katz,et al. Biomarkers and surrogate markers: An FDA perspective , 2004, NeuroRX.
[82] Kaj Blennow,et al. Cerebrospinal fluid protein biomarkers for Alzheimer’s disease , 2004, NeuroRX.
[83] T. Lanz,et al. Studies of Aβ Pharmacodynamics in the Brain, Cerebrospinal Fluid, and Plasma in Young (Plaque-Free) Tg2576 Mice Using the γ-Secretase Inhibitor N2-[(2S)-2-(3,5-Difluorophenyl)-2-hydroxyethanoyl]-N1-[(7S)-5-methyl-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl]-L-alaninamide (LY-411575) , 2004, Journal of Pharmacology and Experimental Therapeutics.
[84] Juan Manuel Maler,et al. Neurochemical diagnosis of Alzheimer’s dementia by CSF Aβ42, Aβ42/Aβ40 ratio and total tau , 2004, Neurobiology of Aging.
[85] W. Klunk,et al. Imaging brain amyloid in Alzheimer's disease with Pittsburgh Compound‐B , 2004, Annals of neurology.
[86] R. Mani. The evaluation of disease modifying therapies in Alzheimer's disease: a regulatory viewpoint , 2004, Statistics in medicine.
[87] B. Hyman,et al. Imaging the pathology of Alzheimer's disease: amyloid-imaging with positron emission tomography. , 2003, Neuroimaging clinics of North America.
[88] K. Blennow,et al. CSF markers for incipient Alzheimer's disease , 2003, The Lancet Neurology.
[89] B. Kramer,et al. A perfect correlate does not a surrogate make , 2003, BMC medical research methodology.
[90] K. Blennow,et al. Measurement of α- and β-secretase cleaved amyloid precursor protein in cerebrospinal fluid from Alzheimer patients , 2003, Experimental Neurology.
[91] B. Dubois,et al. Subacute meningoencephalitis in a subset of patients with AD after Aβ42 immunization , 2003, Neurology.
[92] J. Trojanowski,et al. Biological markers for therapeutic trials in Alzheimer’s disease Proceedings of the biological markers working group; NIA initiative on neuroimaging in Alzheimer’s disease , 2003, Neurobiology of Aging.
[93] R. Hargreaves,et al. Clinical biomarkers in drug discovery and development , 2003, Nature Reviews Drug Discovery.
[94] K. Blennow,et al. CSF Aβ 42 levels correlate with amyloid-neuropathology in a population-based autopsy study , 2003, Neurology.
[95] A. Convit,et al. Longitudinal cerebrospinal fluid tau load increases in mild cognitive impairment , 2002, Neuroscience Letters.
[96] N. Logothetis. The neural basis of the blood-oxygen-level-dependent functional magnetic resonance imaging signal. , 2002, Philosophical transactions of the Royal Society of London. Series B, Biological sciences.
[97] G. Alexander,et al. Longitudinal PET Evaluation of Cerebral Metabolic Decline in Dementia: A Potential Outcome Measure in Alzheimer's Disease Treatment Studies. , 2002, The American journal of psychiatry.
[98] Nick C Fox,et al. Mapping the evolution of regional atrophy in Alzheimer's disease: Unbiased analysis of fluid-registered serial MRI , 2002, Proceedings of the National Academy of Sciences of the United States of America.
[99] S. Younkin,et al. Reduced effectiveness of Aβ1-42 immunization in APP transgenic mice with significant amyloid deposition , 2001, Neurobiology of Aging.
[100] M S Pepe,et al. Phases of biomarker development for early detection of cancer. , 2001, Journal of the National Cancer Institute.
[101] F. Chollet,et al. Within-Session and Between-Session Reproducibility of Cerebral Sensorimotor Activation: A Test–Retest Effect Evidenced with Functional Magnetic Resonance Imaging , 2001, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.
[102] Kaj Blennow,et al. Differential increase in cerebrospinal fluid-acetylcholinesterase after treatment with acetylcholinesterase inhibitors in patients with Alzheimer's disease , 2001, Neuroscience Letters.
[103] K. Blennow,et al. Transient increase in total tau but not phospho-tau in human cerebrospinal fluid after acute stroke , 2001, Neuroscience Letters.
[104] H. Hampel,et al. Detection of tau phosphorylated at threonine 231 in cerebrospinal fluid of Alzheimer's disease patients , 2000, Neuroscience Letters.
[105] K. Blennow,et al. Quantification of tau phosphorylated at threonine 181 in human cerebrospinal fluid: a sandwich ELISA with a synthetic phosphopeptide for standardization , 2000, Neuroscience Letters.
[106] K. Yanagisawa,et al. Age-Dependent Change in the Levels of Aβ40 and Aβ42 in Cerebrospinal Fluid from Control Subjects, and a Decrease in the Ratio of Aβ42 to Aβ40 Level in Cerebrospinal Fluid from Alzheimer’s Disease Patients , 2000, European Neurology.
[107] Nick C Fox,et al. Using serial registered brain magnetic resonance imaging to measure disease progression in Alzheimer disease: power calculations and estimates of sample size to detect treatment effects. , 2000, Archives of neurology.
[108] K. Blennow,et al. Standardization of measurement of β-amyloid(1-42) in cerebrospinal fluid and plasma , 2000, Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis.
[109] M. Bobinski,et al. The histological validation of post mortem magnetic resonance imaging-determined hippocampal volume in Alzheimer's disease , 1999, Neuroscience.
[110] R. Temple,et al. Are surrogate markers adequate to assess cardiovascular disease drugs? , 1999, JAMA.
[111] K. Blennow,et al. Cerebrospinal fluid beta-amyloid(1-42) in Alzheimer disease: differences between early- and late-onset Alzheimer disease and stability during the course of disease. , 1999, Archives of neurology.
[112] S. Hirai,et al. Longitudinal study of cerebrospinal fluid levels of tau, Aβ1–40, and Aβ1–42(43) in Alzheimer's disease: A study in Japan , 1998 .
[113] S. Hirai,et al. Combination assay of CSF Tau, Aβ1-40 and Aβ1-42(43) as a biochemical marker of Alzheimer's disease , 1998, Journal of the Neurological Sciences.
[114] M. Mayhaus,et al. Muscarinic Acetylcholine Receptors Activate Expression of the Egr Gene Family of Transcription Factors* , 1998, The Journal of Biological Chemistry.
[115] C. Jack,et al. Medial temporal atrophy on MRI in normal aging and very mild Alzheimer's disease , 1997, Neurology.
[116] James R. MacFall,et al. Accuracy and reproducibility of brain and tissue volumes using a magnetic resonance segmentation method , 1996, Psychiatry Research: Neuroimaging.
[117] D. DeMets,et al. Surrogate End Points in Clinical Trials: Are We Being Misled? , 1996, Annals of Internal Medicine.
[118] G. Schellenberg,et al. Secreted amyloid β–protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease , 1996, Nature Medicine.
[119] A. Smith,et al. Hippocampal pathology reflects memory deficit and brain imaging measurements in Alzheimer's disease: clinicopathologic correlations using three sets of pathologic diagnostic criteria. , 1996, Dementia.
[120] N. Risch,et al. Statement on use of apolipoprotein E testing for Alzheimer disease. American College of Medical Genetics/American Society of Human Genetics Working Group on ApoE and Alzheimer disease. , 1995, JAMA.
[121] J. Rapoport,et al. Reliability of cerebral measures in repeated examinations with magnetic resonance imaging , 1995, Psychiatry Research: Neuroimaging.
[122] K. Herholz,et al. Long-term effects of phosphatidylserine, pyritinol, and cognitive training in Alzheimer's disease. A neuropsychological, EEG, and PET investigation. , 1994, Dementia.
[123] F Fazio,et al. Comparability of FDG PET studies in probable Alzheimer's disease. , 1993, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.
[124] W Godolphin,et al. Studies of the HER-2/neu proto-oncogene in human breast and ovarian cancer. , 1989, Science.
[125] K. Herholz,et al. Effect of Piracetam on Cerebral Glucose Metabolism in Alzheimer's Disease as Measured by Positron Emission Tomography , 1988, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.
[126] A. Alavi,et al. The [18F]Fluorodeoxyglucose Method for the Measurement of Local Cerebral Glucose Utilization in Mane , 1979, Circulation research.
[127] D. Selkoe. Alzheimer's disease. , 2011, Cold Spring Harbor perspectives in biology.
[128] Nick C Fox,et al. Letter abstract - Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's Disease , 2009 .
[129] Harald Hampel,et al. Decreased activation along the dorsal visual pathway after a 3-month treatment with Galantamine in mild Alzheimer's disease , 2009 .
[130] A. Verma,et al. Amyloid, hypometabolism, and cognition in Alzheimer disease: An [11C]PIB and [18F]FDG PET study , 2008 .
[131] K. Blennow,et al. Intra-individual stability of CSF biomarkers for Alzheimer's disease over two years. , 2007, Journal of Alzheimer's disease : JAD.
[132] M. O. Olde Rikkert,et al. Current state and future directions of neurochemical biomarkers for Alzheimer's disease. , 2007, Clinical chemistry and laboratory medicine.
[133] Frederik Barkhof,et al. Cholinergic challenge in Alzheimer patients and mild cognitive impairment differentially affects hippocampal activation--a pharmacological fMRI study. , 2006, Brain : a journal of neurology.
[134] K. Blennow,et al. Analytical performance and clinical utility of the INNOTEST® PHOSPHO-TAU(181P) assay for discrimination between Alzheimer's disease and dementia with Lewy bodies , 2006, Clinical chemistry and laboratory medicine.
[135] Yvette I. Sheline,et al. Potential antecedent marker of Alzheimer disease , 2006 .
[136] Katharina Buerger,et al. Measurement of phosphorylated tau epitopes in the differential diagnosis of Alzheimer disease: a comparative cerebrospinal fluid study. , 2004, Archives of general psychiatry.
[137] P. Bossuyt,et al. BMC Medical Research Methodology , 2002 .
[138] 金井 光康. Longitudinal study of cerebrospinal fluid levels of tau, Aβ1-40, and Aβ1-42(43) in Alzheimer's disease : a study in Japan , 1999 .
[139] P Leber,et al. Slowing the progression of Alzheimer disease: methodologic issues. , 1997, Alzheimer disease and associated disorders.
[140] Levels of (cid:1) -Secretase (BACE1) in Cerebrospinal Fluid as a Predictor of Risk in Mild Cognitive Impairment , 2022 .