The Effect of Pomegranate Paste on Neonatal Jaundice Incidence: A Clinical Trial in Women during Pregnancy

Purpose: Some topics such as women’s life style and nutrition and using some special medicines during pregnancy have been discussed and demonstrated as effective factors on infant’ health. Based on recommendations in Iranian traditional medicine, we aimed to evaluate the efficacy of pomegranate paste consumed by women during their pregnancy on the neonatal jaundice incidence. Methods: In this single-blinded controlled clinical trial, 80 healthy pregnant women were randomly divided into 2 groups, as treatment and control. The treatment group members added pomegranate paste to their daily diet from the 34th week of the pregnancy to birth, as administered. The levels of neonates’ bilirubin were checked in the 5th day of the delivery. Results: Both the need of phototherapy and the mean level of neonates’ bilirubin in the group fed with pomegranate paste were significantly lesser compared to control group. The number of neonates who were undergone phototherapy in the pomegranate paste receiving group was significantly lesser than that in the control group (P value = 0.029). By measuring the total bilirubin, statically significant difference between the treatment group and the control group was seen (P value = 0.021). Conclusion: The results of this study suggest the possible effect of adding pomegranate paste to pregnant women’s diet on the incidence of neonatal jaundice.

[1]  G. Theron,et al.  Obesity in pregnancy , 2020, Obstetric Anaesthesia.

[2]  A. Fanaroff,et al.  Clinical trial of tin mesoporphyrin to prevent neonatal hyperbilirubinemia , 2016, Journal of Perinatology.

[3]  P. Adibi,et al.  The Role of Syndrome Differentiation in the Clinical Efficacy of Punica Granatum on Patients with Ulcerative Colitis , 2016, Iranian journal of medical sciences.

[4]  Pradyuman Kumar,et al.  Optimization of spray drying conditions for production of quality pomegranate juice powder , 2016 .

[5]  M. Kianmehr,et al.  The effect of massage on neonatal jaundice in stable preterm newborn infants: a randomized controlled trial. , 2015, JPMA. The Journal of the Pakistan Medical Association.

[6]  Z. Abdolazimi,et al.  Effect of Punica granatum L. Flower Water Extract on Five Common Oral Bacteria and Bacterial Biofilm Formation on Orthodontic Wire , 2014, Iranian journal of public health.

[7]  S. Eslami,et al.  Omega-3 and omega-6 content of medicinal foods for depressed patients: implications from the Iranian Traditional Medicine , 2014, Avicenna journal of phytomedicine.

[8]  M. Longtine,et al.  Punicalagin, a polyphenol in pomegranate juice, downregulates p53 and attenuates hypoxia-induced apoptosis in cultured human placental syncytiotrophoblasts. , 2013, American journal of physiology. Endocrinology and metabolism.

[9]  M. Kamalinejad,et al.  Presenting anti-diabetic plants in Iranian traditional medicine , 2012 .

[10]  S. Ashkani-Esfahani,et al.  Investigating the Efficacy of Zizyphus Jujuba on Neonatal Jaundice , 2011, Iranian journal of pediatrics.

[11]  M. Miguel,et al.  Pomegranate (Punica granatum L.): A medicinal plant with myriad biological properties - A short review , 2010 .

[12]  F. Icier,et al.  Ohmic and Conventional Heating of Pomegranate Juice: Effects on Rheology, Color, and Total Phenolics , 2009 .

[13]  K. Rezaei,et al.  Identification and quantification of phenolic compounds and their effects on antioxidant activity in pomegranate juices of eight Iranian cultivars , 2009 .

[14]  Julie S. Jurenka.  Therapeutic applications of pomegranate (Punica granatum L.): a review. , 2008, Alternative medicine review : a journal of clinical therapeutic.

[15]  R. Elashoff,et al.  Phase II Study of Pomegranate Juice for Men with Rising Prostate-Specific Antigen following Surgery or Radiation for Prostate Cancer , 2006, Clinical Cancer Research.

[16]  S. Samani,et al.  The Effect of Purgative Manna on the Infant Jaundice , 2005 .

[17]  A. Bader,et al.  Herbal medicinal products during pregnancy: are they safe? , 2002, BJOG : an international journal of obstetrics and gynaecology.

[18]  P. Dennery.  Pharmacological interventions for the treatment of neonatal jaundice , 2002 .

[19]  E. Ernst.  Herbal medicinal products during pregnancy? , 2002, Phytomedicine : international journal of phytotherapy and phytopharmacology.

[20]  T. Fok.  Neonatal Jaundice — Traditional Chinese Medicine Approach , 2001, Journal of Perinatology.

[21]  T. Fleming.  PDR for herbal medicines. , 1998 .

[22]  G. Grodsky,et al.  Effect of age of rat on development of hepatic carriers for bilirubin: a possible explanation for physiologic jaundice and hyperbilirubinemia in the newborn. , 1970, Metabolism: clinical and experimental.