Multi-modality safety assessment of blood-brain barrier opening using focused ultrasound and definity microbubbles: a short-term study.

[1]  James J. Choi,et al.  In vivo transcranial cavitation detection during ultrasound-induced blood-brain barrier opening , 2010, 2010 IEEE International Ultrasonics Symposium.

[2]  Yao-Sheng Tung,et al.  Identifying the inertial cavitation threshold and skull effects in a vessel phantom using focused ultrasound and microbubbles. , 2010, Ultrasound in medicine & biology.

[3]  Mariano G. Uberti,et al.  Effects of transcranial ultrasound and intravenous microbubbles on blood brain barrier permeability in a large animal model. , 2008, Ultrasound in medicine & biology.

[4]  Elisa E Konofagou,et al.  Noninvasive and Transient Blood-Brain Barrier Opening in the Hippocampus of Alzheimer's Double Transgenic Mice Using Focused Ultrasound , 2008, Ultrasonic imaging.

[5]  Kullervo Hynynen,et al.  Effect of focused ultrasound applied with an ultrasound contrast agent on the tight junctional integrity of the brain microvascular endothelium. , 2008, Ultrasound in medicine & biology.

[6]  Kullervo Hynynen,et al.  Ultrasound for drug and gene delivery to the brain. , 2008, Advanced drug delivery reviews.

[7]  K. Hynynen,et al.  Effects of acoustic parameters and ultrasound contrast agent dose on focused-ultrasound induced blood-brain barrier disruption. , 2008, Ultrasound in medicine & biology.

[8]  K. Hynynen,et al.  Ultrasound Enhanced Delivery of Molecular Imaging and Therapeutic Agents in Alzheimer's Disease Mouse Models , 2008, PloS one.

[9]  B. Zlokovic.  The Blood-Brain Barrier in Health and Chronic Neurodegenerative Disorders , 2008, Neuron.

[10]  S A Small,et al.  Spatio-temporal analysis of molecular delivery through the blood–brain barrier using focused ultrasound , 2007, Physics in medicine and biology.

[11]  Win-Li Lin,et al.  Quantitative evaluation of focused ultrasound with a contrast agent on blood-brain barrier disruption. , 2007, Ultrasound in medicine & biology.

[12]  Natalia Vykhodtseva,et al.  Targeted delivery of doxorubicin to the rat brain at therapeutic levels using MRI‐guided focused ultrasound , 2007, International journal of cancer.

[13]  K. Hynynen,et al.  Use of ultrasound pulses combined with Definity for targeted blood-brain barrier disruption: a feasibility study. , 2007, Ultrasound in medicine & biology.

[14]  Natalia Vykhodtseva,et al.  Focal disruption of the blood-brain barrier due to 260-kHz ultrasound bursts: a method for molecular imaging and targeted drug delivery. , 2006, Journal of neurosurgery.

[15]  Manabu Kinoshita,et al.  Noninvasive localized delivery of Herceptin to the mouse brain by MRI-guided focused ultrasound-induced blood-brain barrier disruption. , 2006, Proceedings of the National Academy of Sciences of the United States of America.

[16]  K. Hynynen,et al.  Targeted delivery of antibodies through the blood-brain barrier by MRI-guided focused ultrasound. , 2006, Biochemical and biophysical research communications.

[17]  K. Hynynen,et al.  Targeted disruption of the blood–brain barrier with focused ultrasound: association with cavitation activity , 2006, Physics in medicine and biology.

[18]  Natalia Vykhodtseva,et al.  MRI-guided targeted blood-brain barrier disruption with focused ultrasound: histological findings in rabbits. , 2005, Ultrasound in medicine & biology.

[19]  Ferenc A. Jolesz,et al.  Local and reversible blood–brain barrier disruption by noninvasive focused ultrasound at frequencies suitable for trans-skull sonications , 2005, NeuroImage.

[20]  K. Hynynen,et al.  Cellular mechanisms of the blood-brain barrier opening induced by ultrasound in presence of microbubbles. , 2004, Ultrasound in medicine & biology.

[21]  Michael Weaver,et al.  Transferrin Receptor Ligand-Targeted Toxin Conjugate (Tf-CRM107) for Therapy of Malignant Gliomas , 2003, Journal of Neuro-Oncology.

[22]  W. Pardridge,et al.  Drug and Gene Delivery to the Brain The Vascular Route , 2002, Neuron.

[23]  H. Winn,et al.  High-intensity focused ultrasound selectively disrupts the blood-brain barrier in vivo. , 2002, Ultrasound in medicine & biology.

[24]  K. Hynynen,et al.  Noninvasive MR imaging-guided focal opening of the blood-brain barrier in rabbits. , 2001, Radiology.

[25]  N. J. Abbott,et al.  Determinants of Passive Drug Entry into the Central Nervous System , 2000, Cellular and Molecular Neurobiology.

[26]  A. Seelig,et al.  Blood-Brain Barrier Permeation: Molecular Parameters Governing Passive Diffusion , 1998, The Journal of Membrane Biology.

[27]  Y. Ben-Ari,et al.  Apoptosis and programmed cell death: a role in cerebral ischemia. , 1998, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

[28]  E. Neuwelt,et al.  Outwitting the blood-brain barrier for therapeutic purposes: osmotic opening and other means. , 1998, Neurosurgery.

[29]  M. Chopp,et al.  Intact, injured, necrotic and apoptotic cells after focal cerebral ischemia in the rat , 1998, Journal of the Neurological Sciences.

[30]  R. Simon,et al.  Early Detection of DNA Strand Breaks in the Brain After Transient Focal Ischemia: Implications for the Role of DNA Damage in Apoptosis and Neuronal Cell Death , 1997, Journal of neurochemistry.

[31]  W. Rosenblum.  Histopathologic clues to the pathways of neuronal death following ischemia/hypoxia. , 1997, Journal of neurotrauma.

[32]  H. Wiśniewski,et al.  Scanning and transmission electron microscopic studies of microvascular pathology in the osmotically impaired blood-brain barrier , 1995, Journal of neurocytology.

[33]  P F Morrison,et al.  Convection-enhanced delivery of macromolecules in the brain. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[34]  T. Leighton.  The Acoustic Bubble , 1994 .

[35]  J. Cammermeyer,et al.  Is the solitary dark neuron a manifestation of postmortem trauma to the brain inadequately fixed by perfusion? , 1978, Histochemistry.

[36]  J. Cammermeyer.  The post-mortem origin and mechanism of neuronal hyperchromatosis and nuclear pyknosis. , 1960, Experimental neurology.

[37]  L. Bakay,et al.  Ultrasonically produced changes in the blood-brain barrier. , 1956, A.M.A. archives of neurology and psychiatry.

[38]  W. Nauta,et al.  FOCAL DESTRUCTION OF NERVOUS TISSUE BY FOCUSED ULTRASOUND: BIOPHYSICAL FACTORS INFLUENCING ITS APPLICATION , 1956, The Journal of experimental medicine.

[39]  Yao-Sheng Tung,et al.  Microbubble-Size Dependence of Focused Ultrasound-Induced Blood–Brain Barrier Opening in Mice In Vivo , 2010, IEEE Transactions on Biomedical Engineering.

[40]  Yao-Sheng Tung,et al.  Molecules of various pharmacologically-relevant sizes can cross the ultrasound-induced blood-brain barrier opening in vivo. , 2010, Ultrasound in medicine & biology.

[41]  James J. Choi,et al.  Noninvasive, transcranial and localized opening of the blood-brain barrier using focused ultrasound in mice. , 2007, Ultrasound in medicine & biology.

[42]  E. Hansson,et al.  Astrocyte–endothelial interactions at the blood–brain barrier , 2006, Nature Reviews Neuroscience.

[43]  B. Jortner.  NEUROPATHOLOGICAL ASSESSMENT IN ACUTE NEUROTOXIC STATES. THE "DARK" NEURON , 2005 .

[44]  W. Pardridge.  The blood-brain barrier: Bottleneck in brain drug development , 2005, NeuroRx : the journal of the American Society for Experimental NeuroTherapeutics.

[45]  R. Macdonald,et al.  Pathophysiology of cerebral ischemia. , 1998, Neurologia medico-chirurgica.

[46]  K. Kogure,et al.  Molecular and biochemical events within the brain subjected to cerebral ischemia (targets for therapeutical intervention). , 1997, Clinical neuroscience.